Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (II) and compounds of formula (III), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: Small molecule inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula (I), and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs.

Abstract: A fryer and method for cooking food products is provided that automates the movement of baskets carrying the food products. The fryer) includes a cooking chamber with a heating element located therein for heating cooking medium in the cooking chamber. The fryer also includes at least one vertical transport assembly that selectively engages with and moves the basket vertically into and out of the cooking medium. A horizontal transport assembly selectively engages with and moves the basket horizontally between different positions. The horizontal transport assembly hands off the basket to and from the vertical transport assembly, and first and second hooks on the horizontal transport assembly engage with front and rear receiving mechanisms on the basket to continuously maintain at least two points of contact with the basket. This allows for controlled pivotal movements of the basket when food products are to be added or removed from the basket.

Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: A fryer and method for cooking food products is provided that automates the movement of baskets carrying the food products. The fryer includes a cooking chamber with a heating element located therein for heating cooking medium in the cooking chamber. The fryer also includes at least one vertical transport assembly that selectively engages with and moves the basket vertically into and out of the cooking medium. A horizontal transport assembly selectively engages with and moves the basket horizontally between different positions. The horizontal transport assembly hands off the basket to and from the vertical transport assembly, and first and second hooks on the horizontal transport assembly engage with front and rear receiving mechanisms on the basket to continuously maintain at least two points of contact with the basket. This allows for controlled pivotal movements of the basket when food products are to be added or removed from the basket.

Abstract: A bird resistant lens for preventing a light from becoming fouled and obscured by bird droppings. The lens is provided with an unstable wobble member mounted to the lens by a spring. The spring supports the wobble member in such an manner so as to provide an area that a bird cannot perch upon. The wobble member includes a gutter and drain holes to channel water over the lens and further includes light dispersing ridges to improve the light's visibility.

Abstract: A portable orbiting grinding machine to grind the gas check seat on 155 mm un tubes. The critical sealing surface is ground concentric with the chamber diameter. Instead of moving the gun tube to a specified machine tool, the portable grinding machine can be loaded on a specified tube for grinding the gas check seat then moved to the next tube to start the sequence again. A hydraulically expanded arbor grips the gun tube chamber diameter. An orbital spur gear assembly rotates on the expanding arbor extension and has a longitudinal travel on the extension controlled by a feed mechanism assembly. A removeable grinding quill is held by the spur gear assembly as it rotates. A sleeve type grinding wheel dresser assembly has a blade that may be mechanically actuated to bear against the grinding wheel and is spring loaded away from the grinding wheel when not in use.

Abstract: A mechanical device for initiating the firing of a large cannon, comprising cylindrical case with a generally cylindrical yoke slidably mounted therein with a generally cylindrical hammer in turn mounted in said yoke. A lever is held up against the aft end of the case by means of an internal spring. The device is cocked by moving the lever sidewise in any direction, or directly aft. During cocking the hammer and yoke are moved aft. Upon completion of the cocking movement, the hammer is automatically released and moves forward to strike the firing pin. Upon release of the lever, the yoke and other parts are automatically reset under the action of springs.

Abstract: The invention is an improved device for sectoring screw threads on gun tu. The invention makes it possible to produce a plurality of sectors of screw threads on gun tubes instead of producing a single sector during each operation. The sectoring procedure is a machining process where portions of the screw thread are removed. The device for sectoring screw threads or gun tubes consists of a slide base assembly for positioning and holding other sub-assemblies of the device; a base plate with uprights for attaching to a machine tool bed or table; a clapper box head; and guide bars to provide for the exact positioning and longitudinal movement of the clapper box head.

Abstract: A stand-alone support assembly for supporting at least one pass-through w rest in independent relation to a machine tool includes a base member, a slide base, a horizontal slide block and a vertical slide block which are mutually cooperable to facilitate positioning of a pass-through work rest in three mutually perpendicular planes so as to enable exact positioning of the work rest relative to a workpiece supported by the machine tool.