Patents by Inventor Thomas van der Does
Thomas van der Does has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210171459Abstract: The invention relates to a method for preparing caprolactam comprising recovering a mixture containing 6-aminocaproic acid, from a culture medium comprising biomass, and thereafter cyclising the 6-aminocaproic acid in the presence of superheated steam, thereby forming caprolactam, wherein the weight to weight ratio carbohydrate to 6-aminocaproic acid in said mixture is 0.03 or less.Type: ApplicationFiled: July 17, 2020Publication date: June 10, 2021Inventors: Rudolf Philippus Maria Guit, Thomas Van Der Does, Lourina Madeleine Raamsdonk
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Publication number: 20180222848Abstract: The present invention relates to the hemi sulfuric acid salt of methyl (R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetate, also trivially referred to as the hemi sulfuric acid salt of D-dihydrophenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics.Type: ApplicationFiled: August 2, 2016Publication date: August 9, 2018Inventors: Thomas VAN DER DOES, Harold Monro MOODY, Weidong LI
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Publication number: 20170298406Abstract: The present invention relates to the hemi sulfuric acid salt of D-phenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics and of D-phenylglycine methyl ester free base.Type: ApplicationFiled: September 17, 2015Publication date: October 19, 2017Inventor: Thomas Van Der Does
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Publication number: 20160200677Abstract: The invention relates to a method for preparing caprolactam comprising recovering a mixture containing 6-aminocaproic acid, from a culture medium comprising biomass, and thereafter cyclising the 6-aminocaproic acid in the presence of superheated steam, thereby forming caprolactam, wherein the weight to weight ratio carbohydrate to 6-aminocaproic acid in said mixture is 0.03 or less.Type: ApplicationFiled: December 8, 2015Publication date: July 14, 2016Inventors: Rudolf Philippus Maria GUIT, Thomas VAN DER DOES, Lourina Madeleine RAAMSDONK
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Patent number: 9006391Abstract: The present invention relates to a method for preparing cyclopeptides by means of protection with a substituted boronic acid. The present invention also discloses novel boronate esters of cyclopeptides of general formula (8).Type: GrantFiled: May 6, 2010Date of Patent: April 14, 2015Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.Inventors: Robertus Mattheus De Pater, Dhiredj Chandre Jagesar, Thomas Van Der Does
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Patent number: 8541199Abstract: The present invention relates to a mutant prokaryotic penicillin G acylase derived from a wild-type penicillin G acylase characterized in that the mutant is having an amino acid substitution at one or more amino acid positions selected from the group consisting of amino acid positions A3, A77, A90, A144 A192, B24, B109, B148, B313, B460 and B488 according to the amino acid numbering of the Escherichia coli penicillin G acylase having the amino acid sequence depicted in SEQ ID No: 1.Type: GrantFiled: December 22, 2009Date of Patent: September 24, 2013Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.Inventors: Jan Metske Van Der Laan, Harold Monro Moody, Richard Kerkman, Thomas Van Der Does
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Patent number: 8497088Abstract: The present invention describes a process for the synthesis of a semi-synthetic ?-lactam compound from a nucleus and a side chain selected from the group consisting of D-phenylglycine and D-dihydro-phenylglycine in the form of a side chain ester and an enzyme catalyzing the coupling of the side chain ester to the nucleus characterized in that the side chain ester is not isolated as a solid intermediate.Type: GrantFiled: March 10, 2008Date of Patent: July 30, 2013Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.Inventors: Thomas Van Der Does, Harold Monro Moody, Theodorus Johannes Godfried Maria Van Dooren
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Publication number: 20130030146Abstract: The invention relates to a method for preparing caprolactam comprising recovering a mixture containing 6-aminocaproic acid, from a culture medium comprising biomass, and thereafter cyclising the 6-aminocaproic acid in the presence of superheated steam, thereby forming caprolactam, wherein the weight to weight ratio carbohydrate to 6-aminocaproic acid in said mixture is 0.03 or less.Type: ApplicationFiled: December 22, 2010Publication date: January 31, 2013Applicant: DSM IP ASSETS B.V.Inventors: Rudolf Philippus Maria Guit, Thomas Van Der Does, Lourina Madeleine Raamsdonk
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Publication number: 20120059146Abstract: The present invention relates to a method for preparing cyclopeptides by means of protection with a substituted boronic acid. The present invention also discloses novel boronate esters of cyclopeptides of general formula (8).Type: ApplicationFiled: May 6, 2010Publication date: March 8, 2012Inventors: Robertus Mattheus De Pater, Dhiredj Chandre Jagesar, Thomas Van Der Does
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Publication number: 20110256585Abstract: The present invention relates to a mutant prokaryotic penicillin G acylase derived from a wild-type penicillin G acylase characterized in that the mutant is having an amino acid substitution at one or more amino acid positions selected from the group consisting of amino acid positions A3, A77, A90, A144 A192, B24, B109, B148, B313, B460 and B488 according to the amino acid numbering of the Escherichia coli penicillin G acylase having the amino acid sequence depicted in SEQ ID No: 1.Type: ApplicationFiled: December 22, 2009Publication date: October 20, 2011Inventors: Jan Metske Van Der Laan, Harold Monro Moody, Thomas Van Der Does
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Publication number: 20110104748Abstract: The present invention describes a process for the synthesis of a semi-synthetic ?-lactam compound from a nucleus and a side chain selected from the group consisting of D-phenylglycine and D-dihydro-phenylglycine in the form of a side chain ester and an enzyme catalyzing the coupling of the side chain ester to the nucleus characterized in that the side chain ester is not isolated as a solid intermediate.Type: ApplicationFiled: March 10, 2008Publication date: May 5, 2011Inventors: Thomas Van Der Does, Harold Monro Moody, Theodorus Johannes Godfried Maria Van Dooren
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Publication number: 20100055749Abstract: The present invention relates to a process for preparation of a pharmaceutically acceptable metal salt of clavulanic acid comprising the steps of (a) fermenting of a microorganism capable of producing and excreting the clavulanic acid into the broth; (b) removing biomass and other solid material from the clavulanic acid containing fermentation broth obtained in step (a); (c) acidifying the solution obtained after step (b) to a pH between 1 and 3 and extracting the acidified solution with a partly or fully water-immiscible solvent and separating the clavulanic acid containing extract; (d) mixing the clavulanic acid containing extract obtained in step (c) with a metal donor and at least one additional cosolvent to result in an insoluble, preferably crystalline metal clavulanate salt with a yield of at least 80%; and (e) separating the insoluble, preferably crystalline, metal clavulanate salt from the mixture obtained in step (d).Type: ApplicationFiled: November 29, 2007Publication date: March 4, 2010Inventors: Thomas Van Der Does, Piotr Wnukowski, Bengt Olof Mathias Danielsson, Harold Monro Moody
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Publication number: 20090208999Abstract: The invention relates to crystalline amoxicillin trihydrate powder having a bulk density higher than 0.45 g/ml. The invention also relates to a process for preparing crystalline amoxicillin trihydrate powder, said process comprising: crystallizing amoxicillin trihydrate from a solution containing dissolved amoxicillin; separating the crystals from said solution; and drying the separated crystals, resulting in crystalline powder having a bulk density higher than 0.45 g/ml.Type: ApplicationFiled: April 8, 2009Publication date: August 20, 2009Applicant: DSM IP ASSETS B.V.Inventors: Jan Willem Groenendaal, Everardus Johannus Antoinious Maria Leenderts, Thomas Van Der Does
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Patent number: 7534781Abstract: The invention relates to crystalline amoxicillin trihydrate powder having a bulk density higher than 0.45 g/ml. The invention also relates to a process for preparing crystalline amoxicillin trihydrate powder, said process comprising: crystallizing amoxicillin trihydrate from a solution containing dissolved amoxicillin; separating the crystals from said solution; and drying the separated crystals, resulting in crystalline powder having a bulk density higher than 0.45 g/ml.Type: GrantFiled: March 19, 2004Date of Patent: May 19, 2009Assignee: DSM IP Assets B.V.Inventors: Jan Willem Groenendaal, Everardus Johannus Antonius Maria Leenderts, Thomas Van Der Does
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Publication number: 20040053912Abstract: The invention relates to a process for the preparation of an aqueous solution or suspension of a &bgr;-lactam nucleus and application thereof. The aqueous solution or suspension of the &bgr;-lactam nucleus is prepared by process wherein an enzymatic deacylation of a &bgr;-lactam compound, which compounds comprises a &bgr;-lactam nucleus with a side chain coupled to it via an amide bond and which deacylation reaction is carried out in a mixture of water and an organic solvent and which deacylation leads to a &bgr;-lactam nucleus and a carboxylic acid, is carried out at a pH value of between 2 and 6 so that the carboxylic acid is extracted in situ to the organic solvent.Type: ApplicationFiled: September 29, 2003Publication date: March 18, 2004Inventors: Thomas van der Does, Rienk Henrik Kuipers, Marjon Brigitte Diender, Jeroen Leonardus den Hollander, Adrianus Johannes Jozef Straathof, Lucas Antonius Maria van der Wielen, Joseph Johannes Heijnen
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Publication number: 20020006642Abstract: The invention relates to a method for preparing a &bgr;-lactam antibiotic, wherein an N-substituted &bgr;-lactam, having general formula (I), wherein R0 is hydrogen or C1-3 alkoxy; Y is CH2, oxygen, sulfur, or an oxidized form of sulfur; Z is (a), (b), (c) or (d), wherein R1 is hydrogen, hydroxy, halogen, C1-3 alkoxy, optionally substituted, optionally containing one or more heteroatoms, saturated or unsaturated, branched or straight C1-5 alkyl, preferably methyl, optionally substituted, optionally containing one or more heteroatoms C5-8 cycloalkyl, optionally substituted aryl or heteroaryl, or optionally substituted benzyl; and X is (CH2)m-A-(CH2)n, wherein m and n are the same or different and are chosen from the group of integers 0, 1, 2, 3 or 4 and A is CH═CH, C═C, CHB, C═O, optionally substituted nitrogen, oxygen, sulfur or an optionally oxidized form of sulfur, and B is hydrogen, halogen, hydroxy, C1-3 alkoxy, or optionally substituted methyl, or a salt thereof, is contacted with at leastType: ApplicationFiled: May 3, 1999Publication date: January 17, 2002Inventors: THOMAS VAN DER DOES, JAGDISH CHANDER KAPUR, ERIK DE VROOM
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Patent number: 6107481Abstract: A process to prepare the E isomer of a 3-substituted (6R,7R)-7-phenyl-acetamido-ceph-3-em-4-carboxylic acid from a mixture of the E and Z-isomer of either the corresponding tert-butyl or the corresponding 4-methoxybenzyl ester of a 3-substituted (6R,7R)-7-phenylacetamido-ceph-3-em-4-carboxylate, characterized by the application of a compound selected from the group titanium tetrachloride, tin tetrachloride and tellurium tetrachloride.Type: GrantFiled: July 13, 1999Date of Patent: August 22, 2000Assignee: DSM N.V.Inventors: Erik De Vroom, Thomas Van Der Does
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Patent number: 5922861Abstract: An efficient process for de-esterification has been provided for by application of special tetrahalogenides. By applying this process a new compound, viz. cefesone, and especially the E-isomer thereof, has been prepared.Type: GrantFiled: April 1, 1998Date of Patent: July 13, 1999Assignee: Gist-Brocades B.V.Inventors: Erik De Vroom, Thomas Van Der Does
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Patent number: 4874897Abstract: Bis[di(alkoxyphenyl)phosphino]alkanes are produced by reacting an alkoxyphenyl Grignard with phosphorus trichloride and converting the resulting di(alkoxyphenyl)phosphorus chloride to the corresponding phosphine. The di(alkoxyphenyl)phosphine is reacted with a dihaloalkane to produce the desired bisphosphine.Type: GrantFiled: May 4, 1988Date of Patent: October 17, 1989Assignee: Shell Oil CompanyInventors: Friedrich Bickelhaupt, Thomas van der Does