Patents by Inventor Thomas Van Es

Thomas Van Es has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrotic diseases
    Patent number: 10048250
    Abstract: The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic conditions. The invention provides polypeptide and nucleic acid TARGETs, siRNA sequences based on these TARGETs and antibodies against the TARGETs. The invention is further related to pharmaceutical composition comprising siRNA sequences based on the TARGETs and antibodies against the TARGETs for use in the treatment of fibrotic conditions. The invention further provides in vitro methods for reduction or inhibition of macrophage differentiation into alternatively-activated macrophages (M2).
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: August 14, 2018
    Assignee: GALAPAGOS NV
    Inventors: Richard Antonius Jozef Janssen, Annemarie Nicolette Lekkerkerker, Thomas Van Es, Johannes Melchior Petrus Stallen
  • MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF FIBROTIC DISEASES
    Publication number: 20180045713
    Abstract: The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic conditions. The invention provides polypeptide and nucleic acid TARGETs, siRNA sequences based on these TARGETs and antibodies against the TARGETs. The invention is further related to pharmaceutical composition comprising siRNA sequences based on the TARGETs and antibodies against the TARGETs for use in the treatment of fibrotic conditions. The invention further provides in vitro methods for reduction or inhibition of macrophage differentiation into alternatively-activated macrophages (M2).
    Type: Application
    Filed: August 4, 2017
    Publication date: February 15, 2018
    Inventors: Richard Antonius Jozef JANSSEN, Annemarie Nicolette LEKKERKERKER, Thomas VAN ES, Johannes Melchior Petrus STALLEN
  • MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF FIBROTIC DISEASES
    Publication number: 20160054304
    Abstract: The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic conditions. The invention provides polypeptide and nucleic acid TARGETs, siRNA sequences based on these TARGETs and antibodies against the TARGETs. The invention is further related to pharmaceutical composition comprising siRNA sequences based on the TARGETs and antibodies against the TARGETs for use in the treatment of fibrotic conditions. The invention further provides in vitro methods for reduction or inhibition of macrophage differentiation into alternatively-activated macrophages (M2).
    Type: Application
    Filed: March 7, 2014
    Publication date: February 25, 2016
    Inventors: Richard Antonius Jozef Janssen, Annemarie Nicolete Lekkerkerker, Thomas Van Es, Johannes Melchior Petrus Stallen