Abstract: A cognate specification system manages and enforces digital, canonical representations of entities that are added to and in the system by creating a composite entity key (“EntityKey”) that uniquely and immutably identifies each entity within the system, and that is created based upon the attributes of the entity rather than being arbitrarily assigned. Entities may be organized into various types or cognates, each associated with distinct sets of attributes. A physical or digital referent may be added to the system as an entity by specifying attributes. In such a system, any entity, whether a physical or digital referent, a process, or other type, is uniquely and verifiably identifiable, and may be linked to or associated with other entities, allowing users of the system to produce and access specification granularity beyond traditional approaches focused on systems interoperability.

Abstract: A cognate specification system manages and enforces digital, canonical representations of entities that are added to and in the system by creating a composite entity key (“EntityKey”) that uniquely and immutably identifies each entity within the system, and that is created based upon the attributes of the entity rather than being arbitrarily assigned. Entities may be organized into various types or cognates, each associated with distinct sets of attributes. A physical or digital referent may be added to the system as an entity by specifying attributes. In such a system, any entity, whether a physical or digital referent, a process, or other type, is uniquely and verifiably identifiable, and may be linked to or associated with other entities, allowing users of the system to produce and access specification granularity beyond traditional approaches focused on systems interoperability.

Abstract: A cognate specification system manages and enforces digital, canonical representations of entities that are added to and in the system by creating a composite entity key (“EntityKey”) that uniquely and immutably identifies each entity within the system, and that is created based upon the attributes of the entity rather than being arbitrarily assigned. Entities may be organized into various types or cognates, each associated with distinct sets of attributes. A physical or digital referent may be added to the system as an entity by specifying attributes. In such a system, any entity, whether a physical or digital referent, a process, or other type, is uniquely and verifiably identifiable, and may be linked to or associated with other entities, allowing users of the system to produce and access specification granularity beyond traditional approaches focused on systems interoperability.

Abstract: A cognate specification system manages and enforces digital, canonical representations of entities that are added to and in the system by creating a composite entity key (“EntityKey”) that uniquely and immutably identifies each entity within the system, and that is created based upon the attributes of the entity rather than being arbitrarily assigned. Entities may be organized into various types or cognates, each associated with distinct sets of attributes. A physical or digital referent may be added to the system as an entity by specifying attributes. In such a system, any entity, whether a physical or digital referent, a process, or other type, is uniquely and verifiably identifiable, and may be linked to or associated with other entities, allowing users of the system to produce and access specification granularity beyond traditional approaches focused on systems interoperability.

Abstract: A cognate specification system manages and enforces digital, canonical representations of entities that are added to and in the system by creating a composite entity key (“EntityKey”) that uniquely and immutably identifies each entity within the system, and that is created based upon the attributes of the entity rather than being arbitrarily assigned. Entities may be organized into various types or cognates, each associated with distinct sets of attributes. A physical or digital referent may be added to the system as an entity by specifying attributes. In such a system, any entity, whether a physical or digital referent, a process, or other type, is uniquely and verifiably identifiable, and may be linked to or associated with other entities, allowing users of the system to produce and access specification granularity beyond traditional approaches focused on systems interoperability.

Abstract: Provided are apparatus and methods for tracking a volume of interest in three dimensions in real time, using fewer than 6 DOF tracking information together with an external 6 DOE coordinate system. The apparatus and methods described herein provide more accurate, smaller, and less expensive tracking systems than prior approaches based on full 6 DOF tracking comprising translation and full orientation information. Embodiments may be used in applications such as surgical navigation, gaming, robotics, motion capture, and training.

Abstract: Provided are apparatus and methods for tracking a volume of interest in three dimensions in real time, using fewer than 6 DOF tracking information together with an external 6 DOE coordinate system. The apparatus and methods described herein provide more accurate, smaller, and less expensive tracking systems than prior approaches based on full 6 DOF tracking comprising translation and full orientation information. Embodiments may be used in applications such as surgical navigation, gaming, robotics, motion capture, and training.

Abstract: Nitroreductases, and genes encoding the same, are provided that demonstrate preferential catalytic conversion of the alkylating agent CB1954 into its highly cytotoxic 4-hydroxylamine (4HX) derivative, this derivative demonstrating anticarcinoma properties. Accordingly, the catalytic activity of the nitroreductase enzymes of the present invention may be employed to achieve catalysis of CB1954 into its cytotoxic derivative in a site-directed manner, such as by Directed-Enzyme Prodrug Therapy (DEPT).