Publication number: 20060269532
Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
Type:
Application
Filed:
February 1, 2006
Publication date:
November 30, 2006
Applicant:
Corixa Corporation
Inventors:
Jiangchun Xu, Davin Dillon, Jennifer Mitcham, Susan Harlocker, Yuqiu Jiang, Robert Henderson, Michael Kalos, Gary Fanger, Marc Retter, John Stolk, Craig Day, Thomas Vedvick, Darrick Carter, Samuel Li, Aijun Wang, Yasir Skeiky, William Hepler, John Hural, Patricia McNeill, Raymond Houghton, Carlota Vinals y de Bassols, Teresa Foy, Yoshihiro Watanabe, Madeleine Meagher, Ta Deng
Publication number: 20060024301
Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
Type:
Application
Filed:
September 23, 2005
Publication date:
February 2, 2006
Applicant:
Corixa Corporation
Inventors:
Jiangchun Xu, Davin Dillon, Jennifer Mitcham, Susan Harlocker, Yuqiu Jiang, Steven Reed, Michael Kalos, Gary Fanger, Marc Retter, John Stolk, Craig Day, Thomas Vedvick, Darrick Carter, Samuel Li, Aijun Wang, Yasir Skeiky