Patents by Inventor Thomas Vifian

Thomas Vifian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES
    Publication number: 20170217910
    Abstract: The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is —NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
    Type: Application
    Filed: April 14, 2017
    Publication date: August 3, 2017
    Applicant: LEO LABORATORIES LIMITED
    Inventors: Gunnar GRUE-SØRENSEN, Xifu LIANG, Thomas HÖGBERG, Kristoffer MÅNSSON, Per VEDSØ, Thomas VIFIAN
  • Ingenol-3-acylates III and ingenol-3-carbamates
    Patent number: 9708286
    Abstract: The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is —NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: July 18, 2017
    Assignee: LEO LABORATORIES LIMITED
    Inventors: Gunnar Grue-Sørensen, Xifu Liang, Thomas Högberg, Kristoffer Månsson, Per Vedsø, Thomas Vifian
  • INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES
    Publication number: 20150291551
    Abstract: The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is —NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
    Type: Application
    Filed: June 24, 2015
    Publication date: October 15, 2015
    Applicant: LEO Laboratories Limited
    Inventors: Gunnar GRUE-SØRENSEN, Xifu LIANG, Thomas HÖGBERG, Kristoffer MÅNSSON, Per VEDSØ, Thomas VIFIAN
  • Ingenol-3-acylates III and ingenol-3-carbamates
    Patent number: 9102687
    Abstract: The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is —NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: August 11, 2015
    Assignee: LEO LABORATORIES LIMITED
    Inventors: Gunnar Grue-Sørensen, Xifu Liang, Thomas Högberg, Kristoffer Månsson, Per Vedsø, Thomas Vifian
  • Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases
    Patent number: 8952162
    Abstract: The present invention relates to a compound according to formula I, wherein R1, R2 and A are as defined herein, which exhibit PDE4 inhibitory activity and may be used in the treatment of inflammatory diseases or autoimmune diseases, in particular inflammatory or proliferative dermal diseases.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: February 10, 2015
    Assignee: Leo Pharma A/S
    Inventors: Simon Feldbæk Nielsen, Thomas Vifian, Anne Marie Horneman, Jesper Færgemann Lau
  • INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES
    Publication number: 20140303150
    Abstract: The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is —NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
    Type: Application
    Filed: December 22, 2011
    Publication date: October 9, 2014
    Applicant: LEO Laboratories Limited
    Inventors: Gunnar Grue-Sørensen, Xifu Liang, Thomas Högberg, Kristoffer Månsson, Per Vedsø, Thomas Vifian
  • TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF DERMAL DISEASES
    Publication number: 20120028974
    Abstract: The present invention relates to a compound according to formula I, wherein R1, R2 and A are as defined herein, which exhibit PDE4 inhibitory activity and may be used in the treatment of inflammatory diseases or autoimmune diseases, in particular inflammatory or proliferative dermal diseases.
    Type: Application
    Filed: December 18, 2009
    Publication date: February 2, 2012
    Applicant: LEO PHARMA A/S
    Inventors: Simon Feldbaek Nielsen, Thomas Vifian, Anne Marie Horneman, Jesper Faergemann Lau