Abstract: Disclosed are compositions and methods related to anti-IL-17A antibodies and antigen binding fragments thereof. Additionally provided are bi-specific binding proteins comprising the anti-IL-17A binding domains. Additionally provided are methods of use for the compounds and compositions described herein in the treatment of inflammatory diseases and ocular disorders.

Abstract: Provided herein are PD-L1 binding molecules comprising or conjugated to a toxin, e.g. a Shiga toxin A Subunit derived polypeptide. In some embodiments, the PD-L1 binding molecules are cytotoxic. In some embodiments, the PD-L1 binding molecules are capable of delivering a CD8+ T-cell epitope to an MHC class molecule inside a PD-L1 positive cell. The PD-L1 binding molecules described herein have uses for selectively killing specific cells (e.g., PD-L1 positive tumor cells and/or immune cells); for selectively delivering cargos to specific cells (e.g., PD-L1 positive tumor cells or immune cells), and as therapeutic and/or diagnostic molecules for treating and diagnosing a variety of conditions, including cancers and tumors involving PD-L1 expressing cells (e.g., PD-L1 positive tumor cells or immune cells).

Abstract: Provided herein are PD-L1 binding molecules comprising or conjugated to a toxin, e.g. a Shiga toxin A Subunit derived polypeptide. In some embodiments, the PD-L1 binding molecules are cytotoxic. In some embodiments, the PD-L1 binding molecules are capable of delivering a CD8+ T-cell epitope to an MHC class molecule inside a PD-L1 positive cell. The PD-L1 binding molecules described herein have uses for selectively killing specific cells (e.g., PD-L1 positive tumor cells and/or immune cells); for selectively delivering cargos to specific cells (e.g., PD-L1 positive tumor cells or immune cells), and as therapeutic and/or diagnostic molecules for treating and diagnosing a variety of conditions, including cancers and tumors involving PD-L1 expressing cells (e.g., PD-L1 positive tumor cells or immune cells).

Abstract: Disclosed are compositions and methods related to IL-25 binding molecules.

Abstract: Provided herein are PD-L1 binding molecules comprising or conjugated to a toxin, e.g. a Shiga toxin A Subunit derived polypeptide. In some embodiments, the PD-L1 binding molecules are cytotoxic. In some embodiments, the PD-L1 binding molecules are capable of delivering a CD8+ T-cell epitope to an MHC class molecule inside a PD-L1 positive cell. The PD-L1 binding molecules described herein have uses for selectively killing specific cells (e.g., PD-L1 positive tumor cells and/or immune cells); for selectively delivering cargos to specific cells (e.g., PD-L1 positive tumor cells or immune cells), and as therapeutic and/or diagnostic molecules for treating and diagnosing a variety of conditions, including cancers and tumors involving PD-L1 expressing cells (e.g., PD-L1 positive tumor cells or immune cells).

Abstract: Provided herein are PD-L1 binding molecules comprising or conjugated to a toxin, e.g. a Shiga toxin A Subunit derived polypeptide. In some embodiments, the PD-L1 binding molecules are cytotoxic. In some embodiments, the PD-L1 binding molecules are capable of delivering a CD8+ T-cell epitope to an MEW class molecule inside a PD-L1 positive cell. The PD-L1 binding molecules described herein have uses for selectively killing specific cells (e.g., PD-L1 positive tumor cells and/or immune cells); for selectively delivering cargos to specific cells (e.g., PD-L1 positive tumor cells or immune cells), and as therapeutic and/or diagnostic molecules for treating and diagnosing a variety of conditions, including cancers and tumors involving PD-L1 expressing cells (e.g., PD-L1 positive tumor cells or immune cells).

Abstract: Provided herein are PD-L1 binding molecules comprising or conjugated to a toxin, e.g. a Shiga toxin A Subunit derived polypeptide. In some embodiments, the PD-L1 binding molecules are cytotoxic. In some embodiments, the PD-L1 binding molecules are capable of delivering a CD8+ T-cell epitope to an MHC class molecule inside a PD-L1 positive cell. The PD-L1 binding molecules described herein have uses for selectively killing specific cells (e.g., PD-L1 positive tumor cells and/or immune cells); for selectively delivering cargos to specific cells (e.g., PD-L1 positive tumor cells or immune cells), and as therapeutic and/or diagnostic molecules for treating and diagnosing a variety of conditions, including cancers and tumors involving PD-L1 expressing cells (e.g., PD-L1 positive tumor cells or immune cells).

Abstract: Disclosed herein are novel PD-L1 binding molecules and methods of their use. The disclosed PD-L1 binding molecules include neutralizing anti-PD-L1 antibodies, bi-specific antibodies, and immunotoxins. The description provides for the use of the disclosed PD-L1 binding molecules in the treatment, prevention, inhibition, or reduction of a cancer or metastasis or as part of a treatment regimen including the use of other anti-cancer agents.

Abstract: Disclosed are compositions and methods related to IL-25 binding molecules.

Abstract: A method and system for performing rendering at a given viewpoint of at least one portion of visual areas blinded to a perspective rendering at the given viewpoint are disclosed, the method comprising providing a projection model comprising a first part used for rendering far view and a second part for rendering near view such that at least one portion of the visual areas is rendered using the second part of the projection model and further wherein a transition between the first part of the projection model and the second part of the projection model is characterized by projection vectors substantially similar, obtaining image data, performing a first projection of at least one part of the image data according to the first part of the projection model to generate first projected data, performing a second projection of another part of the image data according to the second part of the projection model to generate second projected data and displaying projected data using the first projected data and the second

Abstract: The present disclosure relates to a blade for a vehicle. Previous blade designs may pose cost consideration issues and may be laborious to install onto the vehicle. The blade disclosed herein may provide a simple, cost-effective, light-weight and robust design which is relatively easy to manufacture and assemble.

Abstract: A lawn and leaf bag that converts into a bag and pocket configuration or bin that allows user to rake or sweep leaves or yard debris directly into bag and pocket configuration without having to manually place leaves into bag by hand. The lawn and leaf bag is converted into a bag and pocket configuration by placing the bag on the ground on its side with the side opening facing upward or skyward and by then folding the left and right bag walls downward at an angle and pulling them outward to form sidewalls, back wall and floor of the bag and pocket configuration. After creating the bag and pocket configuration the user then sweeps or rakes leaves or debris into the configuration and once filled the configuration is then sealed and placed upright for disposal.

Abstract: A suspension system including a front suspension plane located at an intermediate turboshaft engine casing and connecting same to a pylon, a rear suspension plane located at an exhaust casing of the turboshaft engine and connecting same to the pylon, and a failsafe intermediate suspension plane located between the front and rear planes and including at least one connecting rod connecting the turboshaft engine having a structural outer casing to the pylon, the connecting rod mounted on the turboshaft engine with a predetermined clearance that renders the connecting rod inoperable while the suspension system of the rear plane is operating. The connecting rod is advantageously arranged between the outer casing and the pylon, and an element made of a flexible material is combined with the connecting rod to create the predetermined clearance by an elastically deformable nature thereof.

Abstract: A method and system for performing rendering at a given viewpoint of at least one portion of visual areas blinded to a perspective rendering at the given viewpoint are disclosed, the method comprising providing a projection model comprising a first part used for rendering far view and a second part for rendering near view such that at least one portion of the visual areas is rendered using the second part of the projection model and further wherein a transition between the first part of the projection model and the second part of the projection model is characterized by projection vectors substantially similar, obtaining image data, performing a first projection of at least one part of the image data according to the first part of the projection model to generate first projected data, performing a second projection of another part of the image data according to the second part of the projection model to generate second projected data and displaying projected data using the first projected data and the second

Abstract: A picture frame assembly, including: a first picture frame including a first connecting element, located at a first end of the first picture frame, and extending away from the first end, the first end including a first surface facing an interior of the first picture frame; and a second picture frame including a second connecting element, located at a second end of the second picture frame, and extending away from the second end, the second end including a second surface facing an interior of the second picture frame. The first connecting element is engaged with the second surface. The second connecting element is engaged with the first surface. The first and second picture frames are fixed to each other via the contact of the first and second connecting elements with the second and first picture frames, respectively.

Abstract: A suspension system including a front suspension plane located at an intermediate turboshaft engine casing and connecting same to a pylon, a rear suspension plane located at an exhaust casing of the turboshaft engine and connecting same to the pylon, and a failsafe intermediate suspension plane located between the front and rear planes and including at least one connecting rod connecting the turboshaft engine having a structural outer casing to the pylon, the connecting rod mounted on the turboshaft engine with a predetermined clearance that renders the connecting rod inoperable while the suspension system of the rear plane is operating. The connecting rod is advantageously arranged between the outer casing and the pylon, and an element made of a flexible material is combined with the connecting rod to create the predetermined clearance by an elastically deformable nature thereof.

Abstract: The invention broadly comprises a device for displaying an object including a stand, at least one arcuate hanger element connected to the stand, and a fastener connected to the at least one arcuate hanger element. In some aspects, the at least one hanger element is symmetrically arranged with respect to the stand. In some aspects, the at least one hanger element comprises a length and at least two hanger elements in the at least one hanger element have different respective lengths. In some aspects, the at least one hanger element is flexible. In some aspects, the at least one hanger element is wire. The at least one hanger element comprises a distal end and the fastener is connected to the distal end. In some aspects, the fastener is a clip.