Patents by Inventor Thomas Vitella

Thomas Vitella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240024866
    Abstract: This disclosure describes single-use test cartridges, cell analyzer apparatus, and methods for automatically performing microscopic cell analysis tasks, such as counting and analyzing blood cells in biological samples. A small measured quantity of a biological sample, such as whole blood, is placed in a mixing bowl on the disposable test cartridge after being inserted into the cell analyzer. The analyzer also deposits a known amount of diluent/stain in the mixing bowl and mixes it with the blood. The analyzer takes a measured amount of the mixture and dispenses in a sample cup on the cartridge in fluid communication with an imaging chamber. The geometry of the imaging chamber is chosen to maintain the uniformity of the mixture, and to prevent cells from crowding or clumping as it is transferred into the imaging chamber by the analyzer. Images of all of the cellular components within the imaging chamber are counted and analyzed to obtain a complete blood count.
    Type: Application
    Filed: February 27, 2023
    Publication date: January 25, 2024
    Inventors: Ronald Jones, Adrian Gropper, Robert Hagopian, Charles Rogers, Thomas Vitella, Tyler Cote, Donald Barry, Dirk Osterloh, Chen Yi
  • Publication number: 20230294089
    Abstract: This disclosure describes single-use test cartridges, cell analyzer apparatus, and methods for automatically performing microscopic cell analysis tasks, such as counting blood cells in biological samples. A small unmeasured quantity of a biological sample such as whole blood is placed in the disposable test cartridge which is then inserted into the cell analyzer. The analyzer isolates a precise volume of the biological sample, mixes it with self-contained reagents and transfers the entire volume to an imaging chamber. The geometry of the imaging chamber is chosen to maintain the uniformity of the mixture, and to prevent cells from crowding or clumping, when it is transferred into the imaging chamber. Images of essentially all of the cellular components within the imaging chamber are analyzed to obtain counts per unit volume.
    Type: Application
    Filed: October 24, 2022
    Publication date: September 21, 2023
    Inventors: Ronald Jones, Adrian Gropper, Robert Hagopian, Charles Rogers, Thomas Vitella, Donald Barry, JR., Dirk Osterloh, Chen Yi, Tyler Cote
  • Publication number: 20230185070
    Abstract: Disclosed in one aspect is a method for performing a complete blood count (CBC) on a sample of whole blood by metering a predetermined amount of the whole blood and mixing it with a predetermined amount of diluent and stain and transferring a portion thereof to an imaging chamber of fixed dimensions and utilizing an automated microscope with digital camera and cell counting and recognition software to count every white blood cell and red blood corpuscle and platelet in the sample diluent/stain mixture to determine the number of red cells, white cells, and platelets per unit volume, and analyzing the white cells with cell recognition software to classify them.
    Type: Application
    Filed: October 24, 2022
    Publication date: June 15, 2023
    Inventors: Ronald Jones, Adrian Gropper, Robert Hagopian, Charles Rogers, Thomas Vitella, Donald Barry, JR., Dirk Osterloh, Chen Yi, Tyler Cote
  • Patent number: 11590496
    Abstract: This disclosure describes single-use test cartridges, cell analyzer apparatus, and methods for automatically performing microscopic cell analysis tasks, such as counting and analyzing blood cells in biological samples. A small measured quantity of a biological sample, such as whole blood, is placed in a mixing bowl on the disposable test cartridge after being inserted into the cell analyzer. The analayzer also deposits a known amount of diluent/stain in the mixing bowl and mixes it with the blood. The analyzer takes a measured amount of the mixture and dispenses in a sample cup on the cartridge in fluid communication with an imaging chamber. The geometry of the imaging chamber is chosen to maintain the uniformity of the mixture, and to prevent cells from crowding or clumping as it is transferred into the imaging chamber by the analyzer. Images of all of the cellular components within the imaging chamber are counted and analyzed to obtain a complete blood count.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: February 28, 2023
    Assignee: Medica Corporation
    Inventors: Ronald Jones, Adrian Gropper, Robert Hagopian, Charles Rogers, Thomas Vitella, Tyler Cote, Donald Barry, Dirk Osterloh, Chen Yi
  • Patent number: 11480778
    Abstract: Disclosed in one aspect is a method for performing a complete blood count (CBC) on a sample of whole blood by metering a predetermined amount of the whole blood and mixing it with a predetermined amount of diluent and stain and transferring a portion thereof to an imaging chamber of fixed dimensions and utilizing an automated microscope with digital camera and cell counting and recognition software to count every white blood cell and red blood corpuscle and platelet in the sample diluent/stain mixture to determine the number of red cells, white cells, and platelets per unit volume, and analyzing the white cells with cell recognition software to classify them.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: October 25, 2022
    Assignee: Medica Corporation
    Inventors: Ronald Jones, Adrian Gropper, Robert Hagopian, Charles Rogers, Thomas Vitella, Donald Barry, Jr., Dirk Osterloh, Chen Yi, Tyler Cote
  • Patent number: 11478789
    Abstract: This disclosure describes single-use test cartridges, cell analyzer apparatus, and methods for automatically performing microscopic cell analysis tasks, such as counting blood cells in biological samples. A small unmeasured quantity of a biological sample such as whole blood is placed in the disposable test cartridge which is then inserted into the cell analyzer. The analyzer isolates a precise volume of the biological sample, mixes it with self-contained reagents and transfers the entire volume to an imaging chamber. The geometry of the imaging chamber is chosen to maintain the uniformity of the mixture, and to prevent cells from crowding or clumping, when it is transferred into the imaging chamber. Images of essentially all of the cellular components within the imaging chamber are analyzed to obtain counts per unit volume.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: October 25, 2022
    Assignee: Medica Corporation
    Inventors: Ronald Jones, Adrian Gropper, Robert Hagopian, Charles Rogers, Thomas Vitella, Donald Barry, Jr., Dirk Osterloh, Chen Yi, Tyler Cote
  • Publication number: 20210039093
    Abstract: This disclosure describes single-use test cartridges, cell analyzer apparatus, and methods for automatically performing microscopic cell analysis tasks, such as counting and analyzing blood cells in biological samples. A small measured quantity of a biological sample, such as whole blood, is placed in a mixing bowl on the disposable test cartridge after being inserted into the cell analyzer. The analayzer also deposits a known amount of diluent/stain in the mixing bowl and mixes it with the blood. The analyzer takes a measured amount of the mixture and dispenses in a sample cup on the cartridge in fluid communication with an imaging chamber. The geometry of the imaging chamber is chosen to maintain the uniformity of the mixture, and to prevent cells from crowding or clumping as it is transferred into the imaging chamber by the analyzer. Images of all of the cellular components within the imaging chamber are counted and analyzed to obtain a complete blood count.
    Type: Application
    Filed: February 27, 2020
    Publication date: February 11, 2021
    Inventors: Ronald Jones, Adrian Gropper, Robert Hagopian, Charles Rogers, Thomas Vitella, Tyler Cote, Donald Barry, Dirk Osterloh, Chen Yi
  • Publication number: 20200174241
    Abstract: Disclosed in one aspect is a method for performing a complete blood count (CBC) on a sample of whole blood by metering a predetermined amount of the whole blood and mixing it with a predetermined amount of diluent and stain and transferring a portion thereof to an imaging chamber of fixed dimensions and utilizing an automated microscope with digital camera and cell counting and recognition software to count every white blood cell and red blood corpuscle and platelet in the sample diluent/stain mixture to determine the number of red cells, white cells, and platelets per unit volume, and analyzing the white cells with cell recognition software to classify them.
    Type: Application
    Filed: June 6, 2019
    Publication date: June 4, 2020
    Inventors: Ronald Jones, Adrian Gropper, Robert Hagopian, Charles Rogers, Thomas Vitella, Donald Barry, Dirk Osterloh, Chen Yi, Tyler Cote
  • Patent number: 10625259
    Abstract: This disclosure describes single-use test cartridges, cell analyzer apparatus, and methods for automatically performing microscopic cell analysis tasks, such as counting and analyzing blood cells in biological samples. A small measured quantity of a biological sample, such as whole blood, is placed in a mixing bowl on the disposable test cartridge after being inserted into the cell analyzer. The analyzer also deposits a known amount of diluent/stain in the mixing bowl and mixes it with the blood. The analyzer takes a measured amount of the mixture and dispenses in a sample cup on the cartridge in fluid communication with an imaging chamber. The geometry of the imaging chamber is chosen to maintain the uniformity of the mixture, and to prevent cells from crowding or clumping as it is transferred into the imaging chamber by the analyzer. Images of all of the cellular components within the imaging chamber are counted and analyzed to obtain a complete blood count.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: April 21, 2020
    Assignee: Medica Corporation
    Inventors: Ronald Jones, Adrian Gropper, Robert Hagopian, Charles Rogers, Thomas Vitella, Tyler Cote, Donald Barry, Dirk Osterloh, Chen Yi
  • Publication number: 20170328924
    Abstract: Disclosed in one aspect is a method for performing a complete blood count (CBC) on a sample of whole blood by metering a predetermined amount of the whole blood and mixing it with a predetermined amount of diluent and stain and transferring a portion thereof to an imaging chamber of fixed dimensions and utilizing an automated microscope with digital camera and cell counting and recognition software to count every white blood cell and red blood corpuscle and platelet in the sample diluent/stain mixture to determine the number of red cells, white cells, and platelets per unit volume, and analyzing the white cells with cell recognition software to classify them.
    Type: Application
    Filed: November 20, 2015
    Publication date: November 16, 2017
    Inventors: Ronald Jones, Adrian Gropper, Robert Hagopian, Charles Rogers, Thomas Vitella, Tyler Cote, Donald Barry, Dirk Osterloh, Chen Yi
  • Publication number: 20170326549
    Abstract: This disclosure describes single-use test cartridges, cell analyzer apparatus, and methods for automatically performing microscopic cell analysis tasks, such as counting blood cells in biological samples. A small unmeasured quantity of a biological sample such as whole blood is placed in the disposable test cartridge which is then inserted into the cell analyzer. The analyzer isolates a precise volume of the biological sample, mixes it with self-contained reagents and transfers the entire volume to an imaging chamber. The geometry of the imaging chamber is chosen to maintain the uniformity of the mixture, and to prevent cells from crowding or clumping, when it is transferred into the imaging chamber. Images of essentially all of the cellular components within the imaging chamber are analyzed to obtain counts per unit volume.
    Type: Application
    Filed: February 5, 2016
    Publication date: November 16, 2017
    Inventors: Ronald Jones, Adrian Gropper, Charles Rogers, Thomas Vitella, Donald Barry, Dirk Osterloh, Chen Yi, Tyler Cote
  • Patent number: 9767343
    Abstract: This disclosure describes single-use test cartridges, cell analyzer apparatus, and methods for automatically performing microscopic cell analysis tasks, such as counting blood cells in biological samples. A small unmeasured quantity of a biological sample such as whole blood is placed in the disposable test cartridge which is then inserted into the cell analyzer. The analyzer isolates a precise volume of the biological sample, mixes it with self-contained reagents and transfers the entire volume to an imaging chamber. The geometry of the imaging chamber is chosen to maintain the uniformity of the mixture, and to prevent cells from crowding or clumping, when it is transferred into the imaging chamber. Images of essentially all of the cellular components within the imaging chamber are analyzed to obtain counts per unit volume.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: September 19, 2017
    Assignee: Medica Corporation
    Inventors: Ronald Jones, Adrian Gropper, Robert Hagopian, Charles Rogers, Thomas Vitella, Tyler Cote, Donald Barry, Dirk Osterloh, Chen Yi
  • Patent number: 8877276
    Abstract: A beverage forming method and system employing the introduction of air into the heater tank and/or an expansion chamber after liquid delivery is complete. An expansion chamber may be provided at the top of the heater tank and provide a tortuous flow path from an air inlet to the tank outlet.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: November 4, 2014
    Assignee: Keurig Green Mountain, Inc.
    Inventors: Tom Cominelli, James E. Shepard, Thomas Vitella
  • Publication number: 20140141142
    Abstract: A beverage forming method and system employing the introduction of air into the heater tank and/or an expansion chamber after liquid delivery is complete. An expansion chamber may be provided at the top of the heater tank and provide a tortuous flow path from an air inlet to the tank outlet.
    Type: Application
    Filed: January 24, 2014
    Publication date: May 22, 2014
    Applicant: Keurig, Incorporated
    Inventors: Tom Cominelli, James E. Shepard, Thomas Vitella
  • Patent number: 8667892
    Abstract: A beverage forming method and system employing the introduction of air into the heater tank and/or an expansion chamber after liquid delivery is complete. An expansion chamber may be provided at the top of the heater tank and provide a tortuous flow path from an air inlet to the tank outlet.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: March 11, 2014
    Assignee: Keurig, Incorporated
    Inventors: Tom Cominelli, James E. Shepard, Thomas Vitella
  • Patent number: 8580457
    Abstract: The invention provides a fuel cell stack including a layer of encapsulating material disposed about the separator plate, MEA, and reactant manifold, wherein the reactant manifold is bounded at least in part by the encapsulating material. The fuel cell stack also includes a first opening through the plate body to the first face from the second face, and an open channel in the second face extending from the opening toward a periphery of the plate. The invention also provides a fuel cell stack having a first face including an opening for passage of a reactant therethrough, a first reactant flow field defined thereon, and a first raised surface formed thereon substantially surrounding the opening. The first raised surface is configured and adapted to mate with a second surface on a face of an adjacent plate to create a flow obstruction for encapsulating material.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: November 12, 2013
    Assignee: Protonex Technology Corporation
    Inventors: Thomas Vitella, Jeff Baldic, Ronald Rezac, Nick Lauder, Seth Avis, Paul Osenar
  • Publication number: 20130209636
    Abstract: A beverage forming method and system employing the introduction of air into the heater tank and/or an expansion chamber after liquid delivery is complete. An expansion chamber may be provided at the top of the heater tank and provide a tortuous flow path from an air inlet to the tank outlet.
    Type: Application
    Filed: February 9, 2012
    Publication date: August 15, 2013
    Applicant: Keurig, Incorporated
    Inventors: Tom Cominelli, James E. Shepard, Thomas Vitella
  • Patent number: 8124292
    Abstract: The invention provides a fuel cell stack including a layer of encapsulating material disposed about the separator plate, MEA, and reactant manifold, wherein the reactant manifold is bounded at least in part by the encapsulating material. The fuel cell stack also includes a first opening through the plate body to the first face from the second face, and an open channel in the second face extending from the opening toward a periphery of the plate. The invention also provides a fuel cell stack having a first face including an opening for passage of a reactant therethrough, a first reactant flow field defined thereon, and a first raised surface formed thereon substantially surrounding the opening. The first raised surface is configured and adapted to mate with a second surface on a face of an adjacent plate to create a flow obstruction for encapsulating material.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: February 28, 2012
    Assignee: Protonex Technology Corporation
    Inventors: Thomas Vitella, Jeff Baldic, Ronald Rezac, Nick Lauder, Seth Avis, Paul Osenar
  • Patent number: 7914947
    Abstract: The present invention provides, among other things, membrane cassettes and stacks thereof which are suitable for a use in a variety of electrochemical applications. The invention further provides membrane cassettes which comprise one or more external manifolds which deliver reagents and/or coolant to one or more reactant or coolant flow fields of the membrane cassettes. In particular, the present invention describes the insert molding method, whereby the plenums of the external manifolds are created during the stack encapsulation step. The invention describes several methods for creating the manifold runner geometry via insert-molding, machining, or with separate components.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: March 29, 2011
    Assignee: Protonex Technology Corporation
    Inventors: Paul Osenar, Thomas Vitella, Nick Lauder, Seth Avis, David Ferreira, Ronald Rezac
  • Patent number: 7887974
    Abstract: The present invention provides, among other things, membrane cassettes and stacks thereof which are suitable for a use in a variety of electrochemical applications. The invention further provides membrane cassettes which comprise one or more external manifolds which deliver reagents and/or coolant to one or more reactant or coolant flow fields of the membrane cassettes. In particular, the present invention describes the insert molding method, whereby the plenums of the external manifolds are created during the stack encapsulation step. The invention describes several methods for creating the manifold runner geometry via insert-molding, machining, or with separate components.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: February 15, 2011
    Assignee: Protonex Technology Corporation
    Inventors: Paul Osenar, Thomas Vitella, Nick Lauder, Seth Avis, David Ferreira, Ronald Rezac