Patents by Inventor Thomas Vogl
Thomas Vogl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11891418Abstract: The present invention relates to a yeast cell of the Komagataella genus comprising an orthologous promoter of a methylotrophic yeast cell or a variant thereof inducible by derepression, wherein the orthologous promoter is an orthologous formate dehydrogenase (FMD) promoter of a methylotrophic yeast cell.Type: GrantFiled: December 22, 2016Date of Patent: February 6, 2024Assignee: BISY E.U.Inventors: Thomas Vogl, Anton Glieder
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Patent number: 11299086Abstract: A lighting device in a motor vehicle includes a number of illumination devices, which each generate colored light via a plurality of color channels. The illumination devices can be controlled using an electronic control unit. An illumination state of a respective illumination device can be adjusted by color component values and a brightness end value for all color channels. The electronic control unit calculates a color value from the illumination state to be adjusted for each color channel based on the color component value of the respective color channel and the brightness value. The color value is supplied to the respective illumination device. The electronic control unit processes a brightness threshold value used during a dimming-down/dimming-up process for switching-off/on the respective illumination device. The brightness threshold value is determined by the electronic control unit and increases as the lowest color component value decreases.Type: GrantFiled: July 8, 2019Date of Patent: April 12, 2022Assignee: Bayerische Motoren Werke AktiengesellschaftInventors: Stev Grimm, Thomas Vogl, Christian Wagner, Katrin Wildenhof
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Patent number: 11267854Abstract: The present invention relates to mutants of S100A12 having at least one mutation in the high-affinity calcium binding hand or the low-affinity calcium binding hand or the zinc binding region. The present invention also relates to methods of detecting S100A12 dimers in a sample as well as methods of diagnosis using the S100A12 mutant of the invention, as well as to diagnostic compositions and kits comprising such an S100A12 mutant. The present invention further relates to a method of generating an antibody that specifically binds to an S100A12 dimer using the S100A12 mutant of the invention, as well as to an antibody that specifically binds to an S100A12 dimer.Type: GrantFiled: July 18, 2017Date of Patent: March 8, 2022Assignee: Westfaelische Wilhelms-Universitaet MuensterInventors: Johannes Roth, Thomas Vogl
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Patent number: 11253570Abstract: The present application provides for the use of S100A8 or S100A9 homodimer or S100A8/A9 heterodimer in the prevention or treatment of a NF-?B-associated postnatal inflammatory disorder in a newborn subject. Moreover, the present invention relates to a pharmaceutical composition comprising S100A8 or S100A9 homodimer or S100A8/A9 heterodimer and an in vitro method for evaluating the risk of a newborn subject for developing a NF-?B-associated postnatal inflammatory disorder.Type: GrantFiled: November 6, 2017Date of Patent: February 22, 2022Assignees: Medizinische Hochschule Hannover (MHH), Westfalische Wilhelms-Universität MünsterInventors: Dorothee Viemann, Johannes Roth, Thomas Vogl
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Publication number: 20210355173Abstract: The present invention relates to a yeast cell of the Komagataella genus comprising an orthologous promoter of a methylotrophic yeast cell or a variant thereof inducible by derepression, wherein the orthologous promoter is an orthologous formate dehydrogenase (FMD) promoter of a methylotrophic yeast cell.Type: ApplicationFiled: December 22, 2016Publication date: November 18, 2021Inventors: Thomas Vogl, Anton Glieder
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Patent number: 11155824Abstract: An episomal plasmid comprising a gene of interest (GOI) and an autonomously replicating sequence (ARS) which is not operably linked to the GOI, which ARS comprises or consists of a nucleotide sequence identified as any of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:5, or SEQ ID NO:6-11, or a functionally active variant of any of the foregoing which is characterized by at least 60% sequence identity thereto.Type: GrantFiled: September 29, 2016Date of Patent: October 26, 2021Assignee: BISY E.U.Inventors: Thomas Vogl, Anton Glieder, Richard Wasmayer
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Publication number: 20210247407Abstract: The present invention relates to a method of stratifying a subject having no symptoms of acute tonsillitis for tonsillectomy or tonsillotomy, to a method of diagnosing recurrent tonsillitis in a subject having no symptoms of acute tonsillitis and to a method of predicting the risk or the predisposition for recurrence of acute tonsillitis (RAT) in a subject having no symptoms of acute tonsillitis. These methods ae based on the determination of the biomarkers IL-1 ?, IL-18 and S100A8/S100A9 in said subject.Type: ApplicationFiled: June 6, 2019Publication date: August 12, 2021Inventors: Christoph Spiekermann, Thomas Vogl, Johannes Roth
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Publication number: 20210197710Abstract: A lighting device in a motor vehicle includes a number of illumination devices, which each generate colored light via a plurality of color channels. The illumination devices can be controlled using an electronic control unit. An illumination state of a respective illumination device can be adjusted by color component values and a brightness end value for all color channels. The electronic control unit calculates a color value from the illumination state to be adjusted for each color channel based on the color component value of the respective color channel and the brightness value. The color value is supplied to the respective illumination device. The electronic control unit processes a brightness threshold value used during a dimming-down/dimming-up process for switching-off/on the respective illumination device. The brightness threshold value is determined by the electronic control unit and increases as the lowest color component value decreases.Type: ApplicationFiled: July 8, 2019Publication date: July 1, 2021Inventors: Stev GRIMM, Thomas VOGL, Christian WAGNER, Katrin WILDENHOF
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Publication number: 20210044438Abstract: A method for registering a device with a connected computing facility includes registering the device with the computing facility by using a first encryption method, defining, in the computing facility, a user-specific and device-specific second encryption method based on device identification data and user identification data, and communicating the second encryption method from the computing facility to the device for future communication. A communication system and an energy supply network are also provided.Type: ApplicationFiled: July 31, 2020Publication date: February 11, 2021Inventors: CHAITANYA BISALE, WIEBKE FROEHNER, THOMAS VOGL, THOMAS WERNER
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Publication number: 20190374605Abstract: The present application provides for the use of S100A8 or S100A9 homodimer or S100A8/A9 heterodimer in the prevention or treatment of a NF-?B-associated postnatal inflammatory disorder in a newborn subject. Moreover, the present invention relates to a pharmaceutical composition comprising S100A8 or S100A9 homodimer or S100A8/A9 heterodimer and an in vitro method for evaluating the risk of a newborn subjectfor developing a NF-?B-associated postnatal inflammatory disorder.Type: ApplicationFiled: November 6, 2017Publication date: December 12, 2019Inventors: Dorothee Viemann, Johannes Roth, Thomas Vogl
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Patent number: 10350315Abstract: The present application provides quinoline-3-carboxamide compounds covalently linked to a label for use in the diagnosis of an inflammatory disease at local site. The above mentioned compounds can be used to detect or image accumulation of S100A9 in the body of a subject at sites of inflammation, using in vivo non-invasive molecular imaging techniques for the detection of said compounds. Accordingly, labeled quinoline-3-carboxamide compounds can be applied to evaluate the risk of a subject of developing an inflammatory disease and to follow the progress of the disease.Type: GrantFiled: October 29, 2015Date of Patent: July 16, 2019Assignee: Westfaelische Wihelms-Universitaet MuensterInventors: Andreas Faust, Sven Hermann, Johannes Roth, Michael Schaefers, Thomas Vogl
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Publication number: 20190078104Abstract: An episomal plasmid comprising a gene of interest (GOI) and an autonomously replicating sequence (ARS) which is not operably linked to the GOI, which ARS comprises or consists of a nucleotide sequence identified as any of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:5, or SEQ ID NO:6-11, or a functionally active variant of any of the foregoing which is characterized by at least 60% sequence identity thereto.Type: ApplicationFiled: September 29, 2016Publication date: March 14, 2019Inventors: Thomas Vogl, Anton Glieder, Richard Wasmayer
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Publication number: 20180094286Abstract: The present invention relates to a nucleic acid construct comprising a nucleic acid molecule encoding a protein involved in the biosynthesis of a terpenoid or a precursor thereof, wherein said nucleic acid molecule is operably linked to a derepressible promoter.Type: ApplicationFiled: September 30, 2016Publication date: April 5, 2018Applicant: Technische Universitaet GrazInventors: Thomas Vogl, Anton Glieder, Parayil Kumaran Ajikumar
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Publication number: 20180017576Abstract: The present invention relates to a compound for use in a method of diagnosing acute or chronic inflammatory diseases in a subject. In particular, the present invention provides a S100A8/S100A9 heterodimer standard comprising at least one mutation in low- or high-affinity calcium binding hand that can be used in a method of detecting biomarkers of inflammation in a sample. Accordingly, the S100A8/S100A9 heterodimer standard allows for standardizing quantitative immunoassays and quantifying S100A8/S100A9 heterodimers.Type: ApplicationFiled: January 21, 2016Publication date: January 18, 2018Inventors: Johannes Roth, Thomas Vogl
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Publication number: 20170333577Abstract: The present application provides quinoline-3-carboxamide compounds covalently linked to a label for use in the diagnosis of an inflammatory disease at local site. The above mentioned compounds can be used to detect or image accumulation of S100A9 in the body of a subject at sites of inflammation, using in vivo non-invasive molecular imaging techniques for the detection of said compounds. Accordingly, labeled quinoline-3-carboxamide compounds can be applied to evaluate the risk of a subject of developing an inflammatory disease and to follow the progress of the disease.Type: ApplicationFiled: October 29, 2015Publication date: November 23, 2017Inventors: Andreas Faust, Sven Hermann, Johannes Roth, Michael Schaefers, Thomas Vogl
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Patent number: 9822357Abstract: The invention refers to a library of bidirectional expression cassettes or expression vectors comprising a repertoire of bidirectional promoter sequences, each expression cassette comprising a promoter sequence operably linked to a first gene in one direction, and operably linked to an oppositely oriented second gene in the other direction which is different from the first gene, and bidirectional Pichia pastoris or CHO cells promoter sequences. The invention further refers to a method of screening or selecting a bidirectional promoter suitable for expressing at least two GOI in a host cell and a kit comprising a) an expression cassette consisting of the first and second genes and a stuffer sequence separating them, which stuffer sequence comprises a recognition site for a type IIS restriction enzyme at both ends; b) the type IIS restriction enzyme; c) and a repertoire of promoter, preferably a promoter library including bidirectional promoters.Type: GrantFiled: July 7, 2014Date of Patent: November 21, 2017Assignee: TECHNISCHE UNIVERSITAT GRAZInventors: Thomas Vogl, Thomas Kickenweiz, Lukas Sturmberger, Anton Glieder
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Publication number: 20160289270Abstract: Provided is an isolated peptide or a peptidomimetic comprising a sequence corresponding to amino acid positions 431-616 or 411-616 of the human protein TLR4 or corresponding to amino acid positions 84-131 of the human protein MD-2. Provided is also an antibody with a specificity to an epitope that is a region corresponding to amino acid positions 411 to 616 of variant 1 the human protein TLR4. Provided is further an antibody with a specificity to an epitope that is a region corresponding to amino acid positions 86 to 131 of the human protein MD2. Provided is further the use of such antibody in the treatment or diagnosis of an inflammatory disorder. Also provided is an in-vitro method of identifying a compound capable of inhibiting the formation of a complex between one of the above peptides or whole molecules and an S100A8 or S100A9 or S100A8/S100A9 protein or a functional fragment thereof.Type: ApplicationFiled: November 17, 2014Publication date: October 6, 2016Applicant: Westfaelische Wilhelms-Universitaet MuensterInventors: Johannes Roth, Thomas Vogl
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Publication number: 20150210768Abstract: Provided is an antibody with a specificity to an epitope that is a region corresponding to amino acid positions 63-79 or 73-85 of the human protein S100A9. Provided is further an antibody with a specificity to an epitope that is a region corresponding to amino acid positions 55-71 of the human protein S100A8. Provided is further the use of such antibody in the treatment or diagnosis of an inflammatory disorder. Also provided is an in-vitro method of identifying a compound capable of inhibiting the formation of a complex between a peptide corresponding to one of the above epitopes of S100A9 or the above epitope of S100A8 and a TLR4 receptor, where a compound suspected to affect the complex formation is contacted with the peptide and the TLR4 receptor.Type: ApplicationFiled: September 10, 2013Publication date: July 30, 2015Inventors: Johannes Roth, Thomas Vogl
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Publication number: 20150011407Abstract: The invention refers to a library of bidirectional expression cassettes or expression vectors comprising a repertoire of bidirectional promoter sequences, each expression cassette comprising a promoter sequence operably linked to a first gene in one direction, and operably linked to an oppositely oriented second gene in the other direction which is different from the first gene, and bidirectional Pichia pastoris or CHO cells promoter sequences. The invention further refers to a method of screening or selecting a bidirectional promoter suitable for expressing at least two GOI in a host cell and a kit comprising a) an expression cassette consisting of the first and second genes and a stuffer sequence separating them, which stuffer sequence comprises a recognition site for a type IIS restriction enzyme at both ends; b) the type IIS restriction enzyme; c) and a repertoire of promoter, preferably a promoter library including bidirectional promoters.Type: ApplicationFiled: July 7, 2014Publication date: January 8, 2015Inventors: Thomas VOGL, Thomas KICKENWEIZ, Lukas STURMBERGER, Anton GLIEDER
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Patent number: 8888199Abstract: In order to store equipment and tools in the smallest space with at the same time improved access possibilities and orderliness in outdoor areas, a storage means is described for outdoor areas comprising: at least two holding compartments (11), each of which has one or a plurality of closable opening sections (13), wherein the one opening section (13) or the plurality of opening sections (13) jointly, which belong to the same holding compartment (11), have a surface that essentially corresponds to a surface of an outer side of this holding compartment (11), and wherein the opening sections (13) are arranged on at least two adjacent sides of the storage means.Type: GrantFiled: December 20, 2010Date of Patent: November 18, 2014Inventors: Thomas Vogl, Markus Scholz, Jens Armbrüster