Patents by Inventor Thomas W. Chalberg, Jr.

Thomas W. Chalberg, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11892714
    Abstract: An article includes a first ophthalmic lens including a first spectral filter (e.g., a reflective or absorptive spectral filter), and a second ophthalmic lens including a second spectral filter (e.g., a reflective or absorptive spectral filter). The first spectral filter substantially blocks visible light having wavelengths corresponding to a first portion of a spectral sensitivity range of a first type of cone (e.g., S, M, or L cone) and substantially passes visible light having wavelengths in a second, non-overlapping portion of the spectral sensitivity range. The second spectral filter substantially blocks visible light having wavelengths in the second portion of the spectral sensitivity range and substantially passes visible light having wavelengths in the first spectral sensitivity range.
    Type: Grant
    Filed: January 7, 2022
    Date of Patent: February 6, 2024
    Assignee: WaveShift LLC
    Inventor: Thomas W. Chalberg, Jr.
  • Publication number: 20230382064
    Abstract: A method of making a contact lens includes providing a cylindrical blank for the contact lens, the cylindrical blank including a first portion and a second portion. The first portion is formed from a homogenous, optically clear material and the second portion is formed from an inhomogeneous, optically-scattering material. The method includes shaping the cylindrical blank to provide the contact lens. The contact lens includes a first region surrounded by a second region, the first region being formed from the homogenous, optically clear material and the second region being formed from the inhomogeneous, optically-scattering material.
    Type: Application
    Filed: August 4, 2023
    Publication date: November 30, 2023
    Inventor: Thomas W. Chalberg, Jr.
  • Patent number: 11718052
    Abstract: A method of making a contact lens includes providing a cylindrical blank for the contact lens, the cylindrical blank including a first portion and a second portion. The first portion is formed from a homogenous, optically clear material and the second portion is formed from an inhomogeneous, optically-scattering material. The method includes shaping the cylindrical blank to provide the contact lens. The contact lens includes a first region surrounded by a second region, the first region being formed from the homogenous, optically clear material and the second region being formed from the inhomogeneous, optically-scattering material.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: August 8, 2023
    Assignee: SightGlass Vision, Inc.
    Inventor: Thomas W. Chalberg, Jr.
  • Publication number: 20230181030
    Abstract: Ophthalmic lenses and method of manufacturing ophthalmic lenses are disclosed. The lenses are manufactured with markers for aligning the lenses in a particular rotational alignment with respect to a spectacle frame. The lenses can also be provided with scattering parts for defocus to prevent myopia.
    Type: Application
    Filed: May 18, 2021
    Publication date: June 15, 2023
    Inventors: Thomas W. Chalberg, Jr., Peter Hones, Axel Leroy Smith
  • Publication number: 20230016631
    Abstract: A method includes receiving information about a color blindness of a viewer and an electronic display; receiving information about an input image including input R, G, and B values for pixels composing the input image; transforming each pixel's input values to corresponding x and y values in a CIE color space; identifying which of the pixels are within a filter area in the CIE color space; adjusting a color of the pixels that are within the filter area away from a confusion line for the color blind person to provide a corresponding color-modified pixel; generating a color-modified image composed of the color-modified and original pixels; and displaying the color-modified image with the electronic display.
    Type: Application
    Filed: December 9, 2020
    Publication date: January 19, 2023
    Inventors: David William Olsen, Michael Benjamin Selkowe Fertik, Thomas W. Chalberg, Jr.
  • Publication number: 20220397778
    Abstract: An article includes a first ophthalmic lens including a first spectral filter (e.g., a reflective or absorptive spectral filter), and a second ophthalmic lens including a second spectral filter (e.g., a reflective or absorptive spectral filter). The first spectral filter substantially blocks visible light having wavelengths corresponding to a first portion of a spectral sensitivity range of a first type of cone (e.g., S, M, or L cone) and substantially passes visible light having wavelengths in a second, non-overlapping portion of the spectral sensitivity range. The second spectral filter substantially blocks visible light having wavelengths in the second portion of the spectral sensitivity range and substantially passes visible light having wavelengths in the first spectral sensitivity range.
    Type: Application
    Filed: January 7, 2022
    Publication date: December 15, 2022
    Inventor: Thomas W. Chalberg, JR.
  • Publication number: 20220362402
    Abstract: Provided is a unit dose of recombinant adeno-associated virus (AAV) particles for expression of matrix metalloproteinase 3 (MMP-3). Further provided is a unit dose of recombinant MMP-3. Also provided are methods of use thereof, e.g., in transducing the corneal endothelium of a subject; reducing intraocular pressure in an eye of a subject; treating and/or preventing elevated intraocular pressure in a subject; and treating and/or preventing glaucoma in a subject. Subjects include primates.
    Type: Application
    Filed: October 7, 2020
    Publication date: November 17, 2022
    Inventors: Jeffrey O'CALLAGHAN, Thomas W. CHALBERG, Jr., Matthew LAWRENCE, Annahita KERAVALA, Matthew CAMPBELL, Peter HUMPHRIES
  • Publication number: 20220259568
    Abstract: The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in cone cells.
    Type: Application
    Filed: December 20, 2021
    Publication date: August 18, 2022
    Inventors: Thomas W. CHALBERG, JR., Jay NEITZ, Maureen NEITZ
  • Publication number: 20220252904
    Abstract: An ophthalmic lens includes a first region corresponding to a first area of an optical surface of the ophthalmic lens and a second region corresponding to a second area of the optical surface of the ophthalmic lens different from the first area The second region has an optically-switchable component switchable between a first optical state and a second optical state different from the first optical state. In the first optical state the second region partially scatters or defocuses light incident on the second area.
    Type: Application
    Filed: April 22, 2020
    Publication date: August 11, 2022
    Inventors: Peter Hones, Jr., Thomas W. Chalberg, Jr.
  • Publication number: 20220213494
    Abstract: The disclosure provides compositions and methods useful for treating conditions related to Dual Leucine Zipper (DLK), e.g., neurodegenerative disorders including optic neuropathy. The disclosure provides gene constructs and vectors that regulate the activity of Dual Leucine Zipper Kinase (DLK) or Leucine Zipper Kinase (LZK). The disclosure also provides dominant negative DLK (DN-DLK) proteins that inhibit the kinase and/or signaling activity of DLK. The disclosure also provides vectors, pharmaceutical compositions, and methods of inhibiting DLK.
    Type: Application
    Filed: February 13, 2020
    Publication date: July 7, 2022
    Inventor: Thomas W. CHALBERG, Jr.
  • Publication number: 20220146857
    Abstract: A method includes providing an ophthalmic lens having a prescribed optical power, the ophthalmic lens having a surface having a base curvature corresponding to the prescribed optical power, and exposing a material at the surface to laser radiation sufficient to locally reshape the material to form a plurality of lenslets on the surface. The lenslets each have a corresponding optical power that differs from the prescribed optical power of the ophthalmic lens.
    Type: Application
    Filed: March 2, 2020
    Publication date: May 12, 2022
    Inventors: Peter Hones, JR., Thomas W. Chalberg, Jr.
  • Publication number: 20220111015
    Abstract: The present disclosure provides compositions and methods for the prevention or treatment of ocular neovascularization, such as AMD, in a human subject, by administering subretinally a pharmaceutical composition comprising a pharmaceutically effective amount of a vector comprising a nucleic acid encoding soluble Fms-related tyrosine kinase-1 (sFlt-1) protein to the human subject.
    Type: Application
    Filed: May 24, 2021
    Publication date: April 14, 2022
    Inventors: Ian J. CONSTABLE, P. Elizabeth RAKOCZY, Chooi-May LAI, Thomas W. CHALBERG, Jr.
  • Patent number: 11248214
    Abstract: The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in cone cells.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: February 15, 2022
    Assignees: Adverum Biotechnologies, Inc., University of Washington
    Inventors: Thomas W. Chalberg, Jr., Jay Neitz, Maureen Neitz
  • Publication number: 20220035179
    Abstract: Methods and devices for treating a human child having myopia are disclosed. For example, a human child having myopia can be treated by wearing spectacles having one or two myopia control spectacle lenses.
    Type: Application
    Filed: July 12, 2019
    Publication date: February 3, 2022
    Inventors: Joseph Michael Rappon, Thomas W. Chalberg, Jr., Vanessa Anne Tasso-Pinas, I, Yufen Chung, Peter Hones
  • Publication number: 20220011602
    Abstract: An ophthalmic lens includes a lens material having two curved surfaces opposing each other; a light scattering region; a first aperture (e.g., clear or with reduced scattering density/power compared to the light scattering region) surrounded by the light scattering region; and a second aperture (e.g., clear or with reduced scattering density/power compared to the light scattering region) separated from the first clear aperture by a portion of the light scattering region.
    Type: Application
    Filed: December 2, 2019
    Publication date: January 13, 2022
    Inventors: Thomas W. Chalberg, Jr., Peter Hones
  • Patent number: 11221501
    Abstract: Ophthalmic lenses including a spectral filters (e.g., a reflective or absorptive spectral filter) are disclosed. A first of the spectral filters substantially blocks light in a first portion of a spectral sensitivity range of a cone (e.g., S, M, or L cone) and substantially passes light in a second, non-overlapping portion of the spectral sensitivity range. A second spectral filter substantially blocks light in the second portion of the spectral sensitivity range and substantially passes light in the first spectral sensitivity range.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: January 11, 2022
    Assignee: WaveShift LLC
    Inventor: Thomas W. Chalberg, Jr.
  • Patent number: 11205398
    Abstract: A system includes a full-color electronic display, an eye-tracking module arranged to track an eye of a viewer of the display during operation of the system, at least one programmable processor, and a machine-readable medium storing instructions that, when executed by the at least one programmable processor to perform operations, including: (i) assessing uncorrected image data with one or more image frames, including determining an initial color of pixels in an image frame; (ii) assessing, based on data from the eye-tracking module, a location on the display where the viewer's eye is looking; (iii) modifying a color of red pixels from its initial color to a modified red color based on the location of the pixel relative to the location on the display where the viewer's eye is looking and the initial color of the pixel; and (iv) displaying, on the display, the image frames in which the one or more pixels have the modified color and other pixels have their initial color.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: December 21, 2021
    Assignee: WaveShift LLC
    Inventors: Michael Benjamin Selkowe Fertik, Thomas W. Chalberg, Jr.
  • Publication number: 20210388030
    Abstract: Methods and compositions are provided for intravitreally delivering a polynucleotide to cone photoreceptors. Aspects of the methods include injecting a recombinant adeno-associated virus comprising a polynucleotide of interest into the vitreous of the eye. These methods and compositions find particular use in treating ocular disorders associated with cone dysfunction and/or death.
    Type: Application
    Filed: May 5, 2021
    Publication date: December 16, 2021
    Inventors: Thomas W. CHALBERG, JR., Jay NEITZ, Maureen NEITZ
  • Publication number: 20210338716
    Abstract: Methods of treating a subject for a microbial eye condition are provided. Aspects of the methods include administering to the subject an activated sodium chlorite composition, where the compositions include sodium chlorite; and a buffer component prepared from sodium phosphate monobasic monohydrate and citric acid. Also provided are methods of inhibiting a virus associated with a tissue, such as an adenovirus or coronavirus. In addition, delivery devices for administering an activated sodium chlorite composition to a tissue are provided.
    Type: Application
    Filed: April 30, 2021
    Publication date: November 4, 2021
    Inventors: Stephen J. Smith, Thomas W. Chalberg, JR.
  • Publication number: 20210307963
    Abstract: Therapeutic agent delivery devices are provided. Aspects of the devices include an active agent composition and an actuator configured to deliver the active agent composition to a target delivery site. In some instances, aspects of the devices include a syringe comprising a viscous active agent composition, a needle operably coupled to the syringe and an actuator configured to deliver viscous active agent composition from the syringe through the needed to a target delivery site, such as an intravitreal site. In some instances, aspects of the devices include a sleeve comprising a solid formulation of the active agent; a needle operably coupled to the sleeve; and an actuator configured to move the solid formulation from the sleeve and through the needle, e.g., to an intravitreal location.
    Type: Application
    Filed: August 21, 2019
    Publication date: October 7, 2021
    Inventors: Stephen J. Smith, Thomas W. Chalberg, Jr., Espir Gabriel Kahatt, Greg Yedinak