Patents by Inventor Thomas W. Ferkol, Jr.

Thomas W. Ferkol, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bifunctional molecules for delivery of therapeutics
    Patent number: 6261787
    Abstract: A bifunctional molecule consisting of a therapeutic molecule and a ligand which specifically binds a transcytotic receptor can be transported specifically from the basolateral surface of epithelial cells to the apical surface. This approach provides the ability to deliver a therapeutic molecule directly to the apical surface of the epithelium, by targeting the transcytotic receptor with an appropriate ligand. Thus, the highest concentration of the therapeutic molecule will be at the apical surface, where it can have the greatest therapeutic effect.
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: July 17, 2001
    Assignee: Case Western Reserve University
    Inventors: Pamela B. Davis, Thomas W. Ferkol, Jr., Elizabeth Eckman
  • Serpin enzyme complex receptor-mediated gene transfer
    Patent number: 6200801
    Abstract: Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: March 13, 2001
    Assignee: Case Western Reserve University
    Inventors: Thomas W. Ferkol, Jr., Pamela B. Davis, Assem-Galal Ziady
  • Delivery of compacted nucleic acid to cells
    Patent number: 6077835
    Abstract: Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.
    Type: Grant
    Filed: July 13, 1998
    Date of Patent: June 20, 2000
    Assignees: Case Western Reserve University, Ohio University
    Inventors: Richard W. Hanson, Jose C. Perales, Thomas W. Ferkol, Jr.
  • Serpin enzyme complex receptor--mediated gene transfer
    Patent number: 5972901
    Abstract: Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: October 26, 1999
    Assignee: Case Western Reserve University
    Inventors: Thomas W. Ferkol, Jr., Pamela B. Davis, Assem-Galal Ziady
  • Delivery of nucleic acid to cells
    Patent number: 5972900
    Abstract: Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: October 26, 1999
    Assignee: Case Western Reserve University
    Inventors: Thomas W. Ferkol, Jr., Pamela B. Davis
  • Compacted nucleic acids and their delivery to cells
    Patent number: 5844107
    Abstract: Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: December 1, 1998
    Assignee: Case Western Reserve University
    Inventors: Richard W. Hanson, Jose C. Perales, Thomas W. Ferkol, Jr.