Patents by Inventor Thomas W. Hudyma

Thomas W. Hudyma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for the treatment of Hepatitis C
    Patent number: 7547690
    Abstract: The invention encompasses compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: June 16, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert G. Gentles, Xiaofan Zheng, Min Ding, Yong Tu, Ying Han, Piyasena Hewawasam, John F. Kadow, John A. Bender, Kap-Sun Yeung, Katharine A. Grant-Young, Thomas W. Hudyma
  • Compounds for the treatment of hepatitis C
    Patent number: 7541353
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: June 2, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert G. Gentles, Xiaofan Zheng, Min Ding, Yong Tu, Ying Han, Piyasena Hewawasam, John F. Kadow, John A. Bender, Kap-Sun Yeung, Katharine A. Grant-Young, Thomas W. Hudyma
  • Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
    Patent number: 7521441
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: May 7, 2007
    Date of Patent: April 21, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert G. Gentles, Piyasena Hewawasam, Min Ding, Carl P. Bergstrom, Scott W. Martin, Kap-Sun Yeung, Thomas W. Hudyma, Xiaofan Zheng, John A. Bender, John F. Kadow
  • Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
    Patent number: 7485633
    Abstract: The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: March 12, 2007
    Date of Patent: February 3, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Nicholas A. Meanwell, Robert G. Gentles, Min Ding, John A. Bender, John F. Kadow, Piyasena Hewawasam, Thomas W. Hudyma, Xiaofan Zheng
  • Indolobenzazepine HCV NS5B inhibitors
    Patent number: 7473688
    Abstract: The invention encompasses compounds and salts of Formulas I, II, III, and IV as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: January 6, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Carl P. Bergstrom, John A. Bender, Robert G. Gentles, Piyasena Hewawasam, Thomas W. Hudyma, John F. Kadow, Scott W. Martin, Alicia Regueiro-Ren, Kap-Sun Yeung, Yong Tu, Katharine A. Grant-Young, Xiaofan Zheng
  • HCV NS5B inhibitors
    Patent number: 7456165
    Abstract: The invention encompasses compounds of Formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: November 25, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Carl P. Bergstrom, Scott W. Martin, Thomas W. Hudyma
  • Compounds for the Treatment of Hepatitis C
    Publication number: 20080226591
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: March 11, 2008
    Publication date: September 18, 2008
    Inventors: Robert G. Gentles, Xiaofan Zheng, Min Ding, Yong Tu, Ying Han, Piyasena Hewawasam, John F. Kadow, John A. Bender, Kap-Sun Yeung, Katharine A. Grant-Young, Thomas W. Hudyma
  • Compounds for the Treatment of Hepatitis C
    Publication number: 20080227769
    Abstract: The invention encompasses compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: February 28, 2008
    Publication date: September 18, 2008
    Inventors: Robert G. Gentles, Xiaofan Zheng, Min Ding, Yong Tu, Ying Han, Piyasena Hewawasam, John F. Kadow, John A. Bender, Kap-Sun Yeung, Katharine A. Grant-Young, Thomas W. Hudyma
  • Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
    Patent number: 7399758
    Abstract: The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: July 15, 2008
    Inventors: Nicholas A. Meanwell, Robert G. Gentles, Min Ding, John A. Bender, John F. Kadow, Piyasena Hewawasam, Thomas W. Hudyma, Xiaofan Zheng
  • Inhibitors of HCV replication
    Patent number: 7348425
    Abstract: Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: March 25, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Thomas W. Hudyma, Xiaofan Zheng, Feng He, Min Ding, Carl P. Bergstrom, Piyasena Hewawasam, Scott W. Martin, Robert G. Gentles
  • Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors
    Publication number: 20070270406
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: May 7, 2007
    Publication date: November 22, 2007
    Inventors: Robert G. Gentles, Piyasena Hewawasam, Min Ding, Carl P. Bergstrom, Scott W. Martin, Kap-Sun Yeung, Thomas W. Hudyma, Xiaofan Zheng, John A. Bender, John F. Kadow
  • HCV NS5B Inhibitors
    Publication number: 20070185083
    Abstract: The invention encompasses compounds of Formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: February 6, 2007
    Publication date: August 9, 2007
    Inventors: Carl P. Bergstrom, Scott W. Martin, Thomas W. Hudyma
  • Inhibitors of HCV replication
    Patent number: 7153848
    Abstract: Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.
    Type: Grant
    Filed: July 14, 2005
    Date of Patent: December 26, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Thomas W. Hudyma, Xiaofan Zheng, Feng He, Min Ding, Carl P. Bergstrom, Piyasena Hewawasam, Scott W. Martin, Robert G. Gentles
  • O-derivatized nocathiacin derivatives
    Patent number: 7022667
    Abstract: The present invention provides compounds of formula I having potent antibiotic activity, including activity towards Gram-positive bacteria and mycobacteria.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: April 4, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Thomas W. Hudyma, Xiaofan Zheng, B. Narasimhulu Naidu, Margaret E. Sorenson, Alicia Regueiro-Ren, Timothy P. Connolly, John D. Matiskella, Oak K. Kim, Yunhui Zhang, Dane M. Springer, Jason Goodrich, Yasutsugu Ueda, Joanne J. Bronson
  • Compounds useful for treating hepatitis C virus
    Patent number: 6803374
    Abstract: A series of compounds of Formula I are disclosed which are useful in treating viral hepatitus C.
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: October 12, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Eldon Scott Priestley, Carl P. Decicco, Thomas W. Hudyma, Xiaofan Zheng
  • Compounds useful for treating Hepatitis C virus
    Publication number: 20040067976
    Abstract: A series of compounds of Formula I are disclosed which are useful in treating viral hepatitus C.
    Type: Application
    Filed: August 27, 2003
    Publication date: April 8, 2004
    Inventors: Eldon Scott Priestley, Carl P. Decicco, Thomas W. Hudyma, Xiaofan Zheng
  • O-derivatized nocathiacin derivatives
    Publication number: 20040018963
    Abstract: The present invention provides compounds of formula I 1
    Type: Application
    Filed: July 3, 2002
    Publication date: January 29, 2004
    Inventors: Thomas W. Hudyma, Xiaofan Zheng, B. Narasimhulu Naidu, Margaret E. Sorenson, Alicia Regueiro-Ren, Timothy P. Connolly, John D. Matiskella, Oak K. Kim, Yunhui Zhang, Dane M. Springer, Jason Goodrich, Yasutsugu Ueda, Joanne J. Bronson
  • Water soluble prodrugs of azole compounds
    Patent number: 6620934
    Abstract: Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formula wherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and n, m, p, R1, R2, R3, and R4 are as defined in the specification.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: September 16, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Thomas W. Hudyma, Oak K. Kim, Xiaofan Zheng
  • Water soluble prodrugs of azole compounds
    Patent number: 6620799
    Abstract: Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided having the general formula wherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and n, m, p, R1, R2, R3, and R4 are as defined in the specification.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: September 16, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Thomas W. Hudyma, Oak K. Kim, Xiaofan Zheng
  • Compounds useful for treating hepatitis C virus
    Publication number: 20030134853
    Abstract: A series of compounds of Formula I are disclosed which are useful in treating viral hepatitus C.
    Type: Application
    Filed: September 26, 2002
    Publication date: July 17, 2003
    Inventors: Eldon Scott Priestley, Carl P. Decicco, Thomas W. Hudyma, Xiaofan Zheng