Patents by Inventor Thomas W. McMullin

Thomas W. McMullin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • YEAST CELLS HAVING REDUCTIVE TCA PATHWAY FROM PYRUVATE TO SUCCINATE AND OVEREXPRESSING AN EXOGENOUS NAD(P+) TRANSHYDROGENASE ENZYME
    Publication number: 20240052383
    Abstract: Yeast cells having a reductive TCA pathway from pyruvate or phosphoenolpyruvate to succinate, and which include at least one exogenous gene overexpressing an enzyme in that pathway, further contain an exogenous transhydrogenase gene.
    Type: Application
    Filed: October 30, 2023
    Publication date: February 15, 2024
    Applicant: CARGILL, INCORPORATED
    Inventors: Arlene M. FOSMER, Vernon L. MCINTOSH, Jr., Thomas W. MCMULLIN, Gregory M. POYNTER, Brian J. RUSH, Kevin T. WATTS
  • Yeast cells having reductive TCA pathway from pyruvate to succinate and overexpressing an exogenous NAD(P+) transhydrogenase enzyme
    Patent number: 11821021
    Abstract: Yeast cells having a reductive TCA pathway from pyruvate or phosphoenolpyruvate to succinate, and which include at least one exogenous gene overexpressing an enzyme in that pathway, further contain an exogenous transhydrogenase gene.
    Type: Grant
    Filed: June 15, 2021
    Date of Patent: November 21, 2023
    Assignee: CARGILL, INCORPORATED
    Inventors: Arlene M. Fosmer, Vernon L. McIntosh, Jr., Thomas W. McMullin, Gregory M. Poynter, Brian J. Rush, Kevin T. Watts
  • COMPOSITIONS AND METHODS FOR SUCCINATE PRODUCTION
    Publication number: 20230193299
    Abstract: The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate.
    Type: Application
    Filed: July 15, 2022
    Publication date: June 22, 2023
    Applicant: CARGILL, INCORPORATED
    Inventors: Kenneth R. FINLEY, Jeanette M. HURYTA, Beth M. MASTEL, Thomas W. McMULLIN, Gregory M POYNTER, Brian J. RUSH, Arlene M. FOSMER, Vernon L. McINTOSH, Jr., Keith M. BRADY, Kevin T. WATTS
  • Compositions and methods for succinate production
    Patent number: 11390873
    Abstract: The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: July 19, 2022
    Assignee: CARGILL, INCORPORATED
    Inventors: Kenneth R. Finley, Jeanette M. Huryta, Beth M. Mastel, Thomas W. McMullin, Gregory M. Poynter, Brian J. Rush, Arlene M. Fosmer, Vernon L. McIntosh, Jr., Keith M. Brady, Kevin T. Watts
  • YEAST CELLS HAVING REDUCTIVE TCA PATHWAY FROM PYRUVATE TO SUCCINATE AND OVEREXPRESSING AN EXOGENOUS NAD(P+) TRANSHYDROGENASE ENZYME
    Publication number: 20210381011
    Abstract: Yeast cells having a reductive TCA pathway from pyruvate or phosphoenolpyruvate to succinate, and which include at least one exogenous gene overexpressing an enzyme in that pathway, further contain an exogenous transhydrogenase gene.
    Type: Application
    Filed: June 15, 2021
    Publication date: December 9, 2021
    Applicant: CARGILL, INCORPORATED
    Inventors: Arlene M. FOSMER, Vernon L. MCINTOSH, JR., Thomas W. MCMULLIN, Gregory M. POYNTER, Brian J. RUSH, Kevin T. WATTS
  • Yeast cells having reductive TCA pathway from pyruvate to succinate and overexpressing an exogenous NAD(P)+ transhydrogenase enzyme
    Patent number: 11041176
    Abstract: Yeast cells having a reductive TCA pathway from pyruvate or phosphoenolpyruvate to succinate, and which include at least one exogenous gene overexpressing an enzyme in that pathway, further contain an exogenous transhydrogenase gene.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: June 22, 2021
    Assignee: CARGILL, INCORPORATED
    Inventors: Brian J. Rush, Kevin T. Watts, Vernon L. McIntosh, Jr., Arlene M. Fosmer, Gregory M. Poynter, Thomas W. McMullin
  • Yeast cells having NADP(H)-dependent reductive TCA pathway from pyruvate to succinate
    Patent number: 10066246
    Abstract: Recombinant yeast cells contain a reductive TCA pathway from phosphoenolpyruvate or pyruvate to succinate. At least one metabolic step in the pathway includes a reaction of NADPH to produce NADP+. The yeast cell contains at least one exogenous NADPH-dependent gene in the pathway from phosphoenolpyruvate or pyruvate to succinate, preferably an NADPH-dependent malate dehydrogensase or fumarate reducase gene (or both).
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: September 4, 2018
    Assignee: CARGILL, INCORPORATED
    Inventors: Brian J. Rush, Kevin T. Watts, Vernon L. McIntosh, Arlene M. Fosmer, Gregory M. Poynter, Thomas W. McMullin
  • Yeast Cells Having Reductive TCA Pathway From Pyruvate To Succinate And Overexpressing An Exogenous NAD(P)+ Transhydrogenase Enzyme
    Publication number: 20180100170
    Abstract: Yeast cells having a reductive TCA pathway from pyruvate or phosphoenolpyruvate to succinate, and which include at least one exogenous gene overexpressing an enzyme in that pathway, further contain an exogenous transhydrogenase gene.
    Type: Application
    Filed: November 17, 2017
    Publication date: April 12, 2018
    Inventors: Brian J. Rush, Kevin T. Watts, Vernon L. McIntosh, JR., Arlene M. Fosmer, Gregory M. Poynter, Thomas W. McMullin
  • Yeast cells having reductive TCA pathway from pyruvate to succinate and overexpressing an exogenous NAD(P)+ transhydrogenase enzyme
    Patent number: 9850507
    Abstract: Yeast cells having a reductive TCA pathway from pyruvate or phosphoenolpyruvate to succinate, and which include at least one exogenous gene overexpressing an enzyme in that pathway, further contain an exogenous transhydrogenase gene.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: December 26, 2017
    Assignees: Cargill, Incorporated, BioAmber Inc.
    Inventors: Brian J. Rush, Kevin T. Watts, Vernon L. McIntosh, Jr., Arlene M. Fosmer, Gregory M. Poynter, Thomas W. McMullin
  • Compositions and Methods for Succinate Production
    Publication number: 20170107526
    Abstract: The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate.
    Type: Application
    Filed: December 21, 2016
    Publication date: April 20, 2017
    Inventors: Kenneth R. FINLEY, Jeanette M. HURYTA, Beth M. MASTEL, Thomas W. MCMULLIN, Gregory M. POYNTER, Brian J. RUSH, Arlene M. FOSMER, Vernon L. MCINTOSH, JR., Keith M. BRADY, Kevin T. WATTS
  • Compositions and methods for succinate production
    Patent number: 9605285
    Abstract: The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate.
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: March 28, 2017
    Assignee: CARGILL, INCORPORATED
    Inventors: Kenneth R. Finley, Jeanette M. Huryta, Beth M. Mastel, Thomas W. McMullin, Gregory M. Poynter, Brian J. Rush, Kevin T. Watts, Arlene M. Fosmer, Vernon L. McIntosh, Jr., Keith M. Brady
  • COMPOSITIONS AND METHODS FOR MALATE AND FUMARATE PRODUCTION
    Publication number: 20160068872
    Abstract: The present application provides genetically modified yeast cell comprising an active malate fermentation pathway and/or an active fumarate fermentation pathway, as well as methods of using these cells to produce malate and/or fumarate.
    Type: Application
    Filed: November 20, 2015
    Publication date: March 10, 2016
    Inventors: Kenneth R. FINLEY, Jeanette M. HURYTA, Beth M. MASTEL, Thomas W. MCMULLIN, Gregory M. POYNTER, Brian J. RUSH, Kevin T. WATTS, Arlene M. FOSMER
  • PRODUCTION OF ISOPRENOIDS
    Publication number: 20150299732
    Abstract: A recombinant yeast that makes an isoprenoid compound is provided. The yeast comprises an endogenous mevalonate pathway comprising (i) an enzyme that converts acetyl-CoA to acetoacetyl-CoA, (ii) an enzyme that converts acetoacetyl-CoA to hydroxymethylglutaryl-CoA, (iii) an enzyme that converts hydroxymethylglutaryl-CoA to mevalonic acid, (iv) an enzyme that converts mevalonic acid to phosphomevalonic acid, (v) an enzyme that converts phosphomevalonic acid to phosphomevalonate, and (vi) an enzyme that converts phosphomevalonate to isopentenyl pyrophosphate. The yeast further comprises heterologous nucleic acid sequences encoding an enzyme that converts hydroxymethylglutaryl-CoA to mevalonic acid, an enzyme that converts mevalonic acid to phosphomevalonic acid, an enzyme that converts phosphomevalonic acid to phosphomevalonate, and an enzyme that converts phosphomevalonate to isopentenyl pyrophosphate.
    Type: Application
    Filed: June 30, 2015
    Publication date: October 22, 2015
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Production of isoprenoids
    Patent number: 9102954
    Abstract: A recombinant yeast that makes an isoprenoid compound is provided. The yeast comprises an endogenous mevalonate pathway comprising (i) an enzyme that converts acetyl-CoA to acetoacetyl-CoA, (ii) an enzyme that converts acetoacetyl-CoA to hydroxymethylglutaryl-CoA, (iii) an enzyme that converts hydroxymethylglutaryl-CoA to mevalonic acid, (iv) an enzyme that converts mevalonic acid to phosphomevalonic acid, (v) an enzyme that converts phosphomevalonic acid to phosphomevalonate, and (vi) an enzyme that converts phosphomevalonate to isopentenyl pyrophosphate. The yeast further comprises heterologous nucleic acid sequences encoding an enzyme that converts hydroxymethylglutaryl-CoA to mevalonic acid, an enzyme that converts mevalonic acid to phosphomevalonic acid, an enzyme that converts phosphomevalonic acid to phosphomevalonate, and an enzyme that converts phosphomevalonate to isopentenyl pyrophosphate.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: August 11, 2015
    Assignee: Arkion Life Sciences, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Yeast Cells Having Reductive TCA Pathway from Pyruvate to Succinate and Overexpressing an Exongenous NAD(P)+ Transhydrogenase Enzyme
    Publication number: 20150203877
    Abstract: Yeast cells having a reductive TCA pathway from pyruvate or phosphoenolpyruvate to succinate, and which include at least one exogenous gene overexpressing an enzyme in that pathway, further contain an exogenous transhydrogenase gene.
    Type: Application
    Filed: July 25, 2013
    Publication date: July 23, 2015
    Inventors: Brian J. Rush, Kevin T. Watts, Vernon L. McIntosh, JR., Arlene M. Fosmer, Gregory M. Poynter, Thomas W. McMullin
  • Yeast Cells Having NADP(H)-Dependent Reductive TCA Pathway from Pyruvate to Succinate
    Publication number: 20150176038
    Abstract: Recombinant yeast cells contain a reductive TCA pathway from phosphoenolpyruvate or pyruvate to succinate. At least one metabolic step in the pathway includes a reaction of NADPH to produce NADP+. The yeast cell contains at least one exogenous NADPH-dependent gene in the pathway from phosphoenolpyruvate or pyruvate to succinate, preferably an NADPH-dependent malate dehydrogensase or fumarate reducase gene (or both).
    Type: Application
    Filed: July 25, 2013
    Publication date: June 25, 2015
    Inventors: Brian J. Rush, Kevin T. Watts, Vernon L. McIntosh, Arlene M. Fosmer, Gregory M. Poynter, Thomas W. McMullin
  • COMPOSITIONS AND METHODS FOR MALATE AND FUMARATE PRODUCTION
    Publication number: 20130309736
    Abstract: The present application provides genetically modified yeast cell comprising an active malate fermentation pathway and/or an active fumarate fermentation pathway, as well as methods of using these cells to produce malate and/or fumarate.
    Type: Application
    Filed: January 25, 2012
    Publication date: November 21, 2013
    Applicant: CARGILL, INCORPORATED
    Inventors: Kenneth R. Finley, Jeanette M. Huryta, Beth M. Mastel, Thomas W. McMullin, Gregory M. Poynter, Brian J. Rush, Kevin T. Watts, Arlene M. Fosmer
  • COMPOSITIONS AND METHODS FOR SUCCINATE PRODUCTION
    Publication number: 20130302866
    Abstract: The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate.
    Type: Application
    Filed: January 25, 2012
    Publication date: November 14, 2013
    Applicants: Bioamber S.A.S., Cargill, Incorporated
    Inventors: Kenneth R. Finley, Jeanette M. Huryta, Beth M. Mastel, Thomas W. McMullin, Gregory M. Poynter, Brian J. Rush, Kevin T. Watts, Arlene M. Fosmer, Vernon L. McIntosh, JR., Keith M. Brady
  • Production of isoprenoids
    Patent number: 8241888
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: August 14, 2012
    Assignee: Arkion Life Sciences, LLC
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin
  • Production of isoprenoids
    Patent number: 8236552
    Abstract: The invention provides a biological method of producing isoprenoids.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: August 7, 2012
    Assignee: Arkion Life Sciences
    Inventors: James R. Millis, Julie Maurina-Brunker, Thomas W. McMullin