Patents by Inventor Thomas W. Pattison

Thomas W. Pattison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxazole and thiazole naphthalenes as antiallergic agents
    Patent number: 4754043
    Abstract: There are disclosed compounds of the formula ##STR1## wherein X is --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, ##STR2## Z is CR or N, where n=1; or Z is O,S, or NR, when n=0; R is hydrogen or loweralkyl;n is 0 or 1;R.sup.1 is hydroxy, amino, loweralkyl sulfonamido, perfluoro loweralkyl sulfonamido or OR;R.sup.2 is hydrogen or loweralkyl;R.sup.3 is hydrogen or loweralkyl; orR.sup.2 and R.sup.3 taken together form a benzene ring; andthe dotted line represents an optional double bond;and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like.
    Type: Grant
    Filed: October 6, 1986
    Date of Patent: June 28, 1988
    Assignee: American Home Products Corporation
    Inventors: Anthony F. Kreft, III, John H. Musser, Thomas W. Pattison, John P. Yardley
  • Imidazolylmethoxy naphthalene compounds as antiallergic agents
    Patent number: 4719308
    Abstract: There are disclosed compounds of the formula ##STR1## wherein X is --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, ##STR2## Z is CR or N, when n=1; or Z is O, S, or NR, when n=0, R is hydrogen or loweralkyl;n is 0 or 1;R.sup.1 is hydroxy, amino, loweralkyl sulfonamido, perfluoro loweralkyl sulfonamido or OR;R.sup.2 is hydrogen or loweralkyl;R.sup.3 is hydrogen or loweralkyl; orR.sup.2 and R.sup.3 taken together form a benzene ring; andthe dotted line represents an optional double bond;and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like.
    Type: Grant
    Filed: October 6, 1986
    Date of Patent: January 12, 1988
    Assignee: American Home Products Corporation
    Inventors: Anthony F. Kreft, III, John H. Musser, Thomas W. Pattison, John P. Yardley
  • Quinolinyl (or pyridinyl) methoxy substituted naphthalene compounds as antiallergic agents
    Patent number: 4661596
    Abstract: There are disclosed compounds of the formula ##STR1## wherein X is --Ch.sub.2 CH.sub.2 --, --CH=CH--, ##STR2## Z is CR or N, when n=1; or Z is O, S, or NR, when n=0; R is hydrogen or loweralkyl;n is 0 or 1;R.sup.1 is hydroxy, amino, loweralkyl sulfonamido, perfluoro loweralkyl sulfonamido or OR;R.sup.2 is hydrogen or loweralkyl;R.sup.3 is hydrogen or loweralkyl; orR.sup.2 and R.sup.3 taken together form a benzene ring; andthe dotted line represents an optional double bond;and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like.
    Type: Grant
    Filed: October 3, 1985
    Date of Patent: April 28, 1987
    Assignee: American Home Products Corporation
    Inventors: Anthony F. Kreft, III, John H. Musser, Thomas W. Pattison, John P. Yardley
  • 3(2-quinolinylalkoxy)phenols
    Patent number: 4642347
    Abstract: There are disclosed compounds of the formula ##STR1## wherein Z is CR or N, when n=1; or Z is O, S, or NR, when n=0; n is 0 or 1; p is 1-10; R.sup.1 is hydrogen, loweralkyl, loweralkoxy or halo; R.sup.2 is hydrogen, loweralkyl, loweralkoxy or halo; or R.sup.1 and R.sup.2 taken together form a benzene ring; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like.
    Type: Grant
    Filed: May 21, 1985
    Date of Patent: February 10, 1987
    Assignee: American Home Products Corporation
    Inventors: Anthony F. Kreft, III, Thomas W. Pattison, John H. Musser
  • Antiinflammatory 5H-tetrazolo (5,1-c)(1,4)benzodiazepine derivatives
    Patent number: 4495101
    Abstract: The compounds of the formula ##STR1## in which R is hydrogen, halogen, alkyl, alkoxy, hydroxyl, nitro or cyano; andR.sup.2 is .dbd.O, .dbd.S, H.sub.2, --SCH.sub.3, or an amino group; with the proviso that when R is chloro in 8-position, R.sup.2 must be other than oxygen or sulfur; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 28, 1983
    Date of Patent: January 22, 1985
    Assignee: American Home Products Corporation
    Inventors: Dieter H. Klaubert, Stanley C. Bell, Thomas W. Pattison, Richard W. Rees