Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: A spacer apparatus for maximizing a user's range of motion on a weightlifting exercise machine. The spacer apparatus includes a first interlocking part having a semi-circular body extending between top and bottom portions, and a lock portion extending between first and second ends of the semi-circular body. The first and second ends are spaced and a keyway is between the first and second ends. The spacer apparatus includes a second interlocking part having a body extending, at least partially, between first and second ends, and entirely between top and bottom portions. The body of the second interlocking part has a semi-circular portion with a key portion extending therefrom. In the interlocked configuration, the key portion extends between the keyway such that an outer perimeter of the first interlocking part and an outer perimeter of the second interlocking part are aligned.

Abstract: A spacer apparatus for maximizing a user's range of motion on a weightlifting exercise machine. The spacer apparatus includes a first interlocking part having a semi-circular body extending between top and bottom portions, and a lock portion extending between first and second ends of the semi-circular body. The first and second ends are spaced and a keyway is between the first and second ends. The spacer apparatus includes a second interlocking part having a body extending, at least partially, between first and second ends, and entirely between top and bottom portions. The body of the second interlocking part has a semi-circular portion with a key portion extending therefrom. In the interlocked configuration, the key portion extends between the keyway such that an outer perimeter of the first interlocking part and an outer perimeter of the second interlocking part are aligned.

Abstract: A spacer apparatus for maximizing a user's range of motion on a weightlifting exercise machine. The spacer apparatus includes a first interlocking part having a semi-circular body extending between top and bottom portions, and a lock portion extending between first and second ends of the semi-circular body. The first and second ends are spaced and a keyway is between the first and second ends. The spacer apparatus includes a second interlocking part having a body extending, at least partially, between first and second ends, and entirely between top and bottom portions. The body of the second interlocking part has a semi-circular portion with a key portion extending therefrom. In the interlocked configuration, the key portion extends between the keyway such that an outer perimeter of the first interlocking part and an outer perimeter of the second interlocking part are aligned.

Abstract: A spacer apparatus for maximizing a user's range of motion on a weightlifting exercise machine. The spacer apparatus includes a first interlocking part having a semi-circular body extending between top and bottom portions, and a lock portion extending between first and second ends of the semi-circular body. The first and second ends are spaced and a keyway is between the first and second ends. The spacer apparatus includes a second interlocking part having a body extending, at least partially, between first and second ends, and entirely between top and bottom portions. The body of the second interlocking part has a semi-circular portion with a key portion extending therefrom. In the interlocked configuration, the key portion extends between the keyway such that an outer perimeter of the first interlocking part and an outer perimeter of the second interlocking part are aligned.

Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.

Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.

Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.

Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.