Abstract: The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.

Abstract: Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.

Abstract: A method of printing a multi-material part in a layer-wise manner with an extrusion-based 3D printer includes providing a sliced digital model of a multi-material part and determining a number of materials in each of the slices of the digital mode. The method includes utilizing a digital model of a purge tower having N subdivisions having a closed geometry, wherein N is the number of print heads needed to print the part that is greater than or equal to three, each adjacent subdivision contact one another along an interface and assigning each print head to one subdivision and to tool paths forming the one subdivision in each layer. The method includes reassigning the assigned subdivision within the purge tower of an inactive print head in a layer to a print head that is active in the layer of the multi-material part.

Abstract: A train control system includes independent virtual in-train forces modelling engines onboard each of a plurality of locomotives in a train. Each of the plurality of locomotives may also include an analytics engine and a calibration engine configured to assimilate, analyze, and calibrate real time information from other locomotives and from draft gears and couplers interconnecting the locomotives with determinations made by the independent virtual in-train forces modelling engine onboard the respective locomotive, with the plurality of locomotives of the train being configured to operate collectively and coordinate their own acceleration values based on a common goal of minimizing in-train forces without being dependent on a command from a lead locomotive or central command.

Abstract: Methods and devices for controlling a camera on a vehicle may include determining a duty status of a driver of the vehicle. The methods and devices may also include controlling a recording status of at least one camera of a camera system on the vehicle based on the duty status.

Abstract: Methods and devices for controlling a camera on a vehicle may include determining a duty status of a driver of the vehicle. The methods and devices may also include controlling a recording status of at least one camera of a camera system on the vehicle based on the duty status.

Abstract: Improved surgical instruments are provided including improved suture passers, improved drill guides for forming holes in bones adjacent a joint at locations referenced to the joint anatomy, and improved osteotomy guides.

Abstract: Certain embodiments relate to method of passing a suture through a material using a suture passer. In certain embodiments, the suture passer includes a housing defining a linear motion axis, a needle mounted for translation along the motion axis, and a foot mounted to the housing. The foot has a distal portion with a proximal facing surface extending along a distal portion axis crossing the motion axis and a distal facing surface, the distal portion including an opening in the proximal facing surface aligned with the motion axis and able to receive the needle in the second position. In certain embodiments, a method includes positioning a distal portion of the foot of the suture passer behind the material, extending the needle through the material and into the opening in the distal portion, and retracting the needle to retrieve a bight of suture from the distal portion proximally through the material.

Abstract: Devices and methods are provided to conduct fluid away from or deliver fluid to an area of a treatment site of a patient's body. In one aspect of the invention, a catheter includes a terminal end with a fluid exchange portion. The terminal end may further include a diffuser. The terminal end may further include a barrier.

Abstract: Methods and devices for controlling a camera on a vehicle may include determining a duty status of a driver of the vehicle. The methods and devices may also include controlling a recording status of at least one camera of a camera system on the vehicle based on the duty status.

Abstract: A guide and method useful in cutting and rejoining bones is presented. The guide is particularly useful in performing an osteotomy of a long bone adjacent a joint such as a hand or foot.

Abstract: Watercraft with dual, in-line flotation are detailed. Front and rear floats may be bridged by a seating assembly and allow both feet-up and feet-down positioning of a user of the craft. The watercraft may be disassembled and then reassembled compactly for transport or storage, with the compactly reassembled craft including wheels or capable of being placed onto a hand trolley if desired to facilitate its carriage. Also detailed are watercraft in which forward flotation is provided by two front floats forming a pontoon configuration.

Abstract: Watercraft with dual, in-line flotation are detailed. Front and rear floats may be bridged by a seating assembly and allow both feet-up and feet-down positioning of a user of the craft. The watercraft may be disassembled and then reassembled compactly for transport or storage, with the compactly reassembled craft including wheels or capable of being placed onto a hand trolley if desired to facilitate its carriage. Also detailed are watercraft in which forward flotation is provided by two front floats forming a pontoon configuration.

Abstract: A computer-implemented method of managing computer network resources by one or more processors is provided. The method includes acquiring data from an external device over a network, storing operational programs and data in a storage, and compiling the acquired data into a live object. The method also includes linking resources identified in the live object via service modules and interfaces, activating the links of the identified resources to acquire information from the resources and to personalize performance of the resources, and creating a vectoring engine to implement specific objectives of the live object and an active plate. The method further includes creating a box that establishes an independent relationship with the live object, managing the service modules and interfaces of the system to execute the specific objectives, managing the box to query data contained in the live object, and transmitting results of the executed specific objectives to the external device.

Abstract: A computer network-resource management system and method are provided that use mobile and deployed devices to capture and transmit an event for instant conversion into an instrument by which to pursue the actionable or acquirable element of the event. Mobile phones and other network devices supply the resource management system the “triangulatable” data necessary for it to allocate, personalize, and activate network resources in support of evolutionary needs. Evolutionary needs are often subject to changing states, some of which dynamically transition from simple to complex states.

Abstract: Instruments and techniques to pass a suture, particularly in instances where access to confined spaces and the ability to pass a suture through difficult to penetrate materials are needed. The instruments and techniques are particularly useful in surgery of the hands and feet.

Abstract: Devices and methods are provided to conduct fluid away from or deliver fluid to an area of a treatment site of a patient's body. In one example, a catheter includes a fluid exchange portion and a member attached to the fluid exchange portion for biasing fluid flow at the treatment site.

Abstract: Devices and methods are provided to conduct fluid away from or deliver fluid to an area of a treatment site of a patient's body. In one aspect of the invention, a catheter includes a terminal end with a fluid exchange portion. The terminal end may further include a diffuser. The terminal end may further include a barrier.

Abstract: Instruments and techniques to pass a suture, particularly in instances where access to confined spaces and the ability to pass a suture through difficult to penetrate materials are needed. According to certain embodiments, a suture passer is provided including a housing, a needle assembly, and a barrel assembly. The needle assembly may include a needle that is displaceable along a linear motion axis of the housing, and which is adapted to engage a suture. The barrel assembly may include a foot having an opening in a proximal facing surface to receive passage of the needle. The foot may include an elbow having proximal and distal portions, with the proximal portion having a distal facing surface that extends along a proximal portion axis diverging distally away from the motion axis, and the distal portion extending distally from the proximal portion and having a proximal facing surface that extends along a distal portion axis that is arranged transverse to the motion axis.

Abstract: Devices and methods are provided to conduct fluid away from or deliver fluid to an area of a treatment site of a patient's body. In one aspect of the invention, a catheter includes a terminal end with a fluid exchange portion. The terminal end may further include a diffuser. The terminal end may further include a barrier.