Patents by Inventor Thomas Wai-Ho Lee

Thomas Wai-Ho Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF CNS DISEASES WITH sGC STIMULATORS
    Publication number: 20190343813
    Abstract: The present disclosure relates to the use of stimulators of soluble guanylate cyclase (sGC), pharmaceutically acceptable salts thereof and pharmaceutical formulations or dosage forms comprising them, alone or in combination with one or more additional agents, for the treatment of various CNS diseases, wherein an increase in sGC stimulation, or an increase in the concentration of nitric oxide (NO), or cyclic guanosine 3?,5?-monophosphate (cGMP) or both, or an upregulation of the NO pathway is desirable.
    Type: Application
    Filed: November 7, 2017
    Publication date: November 14, 2019
    Applicant: Cyclerion Therapeutics, Inc.
    Inventors: Joon Jung, Thomas Wai-Ho Lee, Rajesh R. Iyengar, Nicholas Robert Perl, Peter Germano, Maria D. Ribadeneira, Kim Tang
  • SGC stimulators
    Patent number: 10472363
    Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: November 12, 2019
    Assignee: Cyclerion Therapeutics, Inc.
    Inventors: Glen Robert Rennie, Rajesh R. Iyengar, Thomas Wai-Ho Lee, Paul Allan Renhowe, Joon Jung
  • PYRAZOLE DERIVATIES AS SGC STIMULATORS
    Publication number: 20190284168
    Abstract: Compounds are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: October 19, 2018
    Publication date: September 19, 2019
    Inventors: Timothy Claude BARDEN, James Edward SHEPPECK, Glen Robert RENNIE, Paul Allan RENHOWE, Nicholas PERL, Takashi NAKAI, Ara MERMERIAN, Thomas Wai-Ho LEE, Joon JUNG, James JIA, Karthik IYER, Rajesh R. IYENGAR, G-Yoon Jamie IM
  • sGC STIMULATORS
    Publication number: 20190248794
    Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable.
    Type: Application
    Filed: February 12, 2019
    Publication date: August 15, 2019
    Inventors: Glen Robert Rennie, Rajesh R. Iyengar, Thomas Wai-Ho Lee, Takashi Nakai, Ara Mermerian, Lei Jia, G-Yoon Jamie Im, Paul Allan Renhowe, Joon Jung, Peter Germano, Karthik Iyer, Timothy Claude Barden, Kim Tang
  • sGC STIMULATORS
    Publication number: 20190167679
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: November 2, 2018
    Publication date: June 6, 2019
    Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
  • PYRAZOLE DERIVATIVES AS SGC STIMULATORS
    Publication number: 20190031641
    Abstract: Compounds are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: February 22, 2018
    Publication date: January 31, 2019
    Inventors: Timothy Claude Barden, James Edward Sheppeck, Glen Robert Rennie, Paul Allan Renhowe, Nicholas Perl, Takashi Nakai, Ara Mermerian, Thomas Wai-Ho Lee, Joon Jung, James Jia, Karthik Iyer, Rajesh R. Iyengar, G-Yoon Jamie Im
  • SGC stimulators
    Patent number: 10189809
    Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: January 29, 2019
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Charles Kim, Takashi Nakai, Thomas Wai-Ho Lee, Joel Moore, Nicholas Robert Perl, Jason Rohde, Rajesh R. Iyengar, Ara Mermerian, Angelika Fretzen
  • sGC stimulators
    Patent number: 10183021
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: January 22, 2019
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Takashi Nakai, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie
  • sGC stimulators
    Patent number: 10047095
    Abstract: The present patent application discloses at least the compounds according to Formula I? shown below, or pharmaceutically acceptable salts thereof, wherein ring D, ring A, ring E, ring F, JB, n, JD, J, o, RC1, RC2, W, JE, r, JF, s, Z1, Z2 and Z3 are as defined herein.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: August 14, 2018
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: Nicholas Perl, Takashi Nakai, Thomas Wai-Ho Lee, Glen Robert Rennie, Paul Allan Renhowe, Rajesh R. Iyengar
  • sGC STIMULATORS
    Publication number: 20180155345
    Abstract: The present patent application discloses at least the compounds according to Formula I? shown below, or pharmaceutically acceptable salts thereof, wherein ring D, ring A, ring E, JB, n, JD, J, X, Z, Z1, RC1, RC2, Y, R9, o and W are as defined herein.
    Type: Application
    Filed: September 16, 2015
    Publication date: June 7, 2018
    Applicant: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Glen Robert RENNIE, Nicholas PERL, Ara MERMERIAN, Joon JUNG, James JIA, Rajesh R. IYENGAR, G-Yoon Jamie IM, Timothy Claude BARDEN, James Edward SHEPPECK, Paul Allan RENHOWE, Takashi NAKAI, Thomas Wai-Ho LEE, Karthik IYER
  • sGC STIMULATORS
    Publication number: 20180065971
    Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable.
    Type: Application
    Filed: September 1, 2017
    Publication date: March 8, 2018
    Inventors: Glen Robert Rennie, Rajesh R. Iyengar, Thomas Wai-Ho Lee, Takashi Nakai, Ara Mermerian, James Jia, G-Yoon Jamie Im, Paul Allan Renhowe, Joon Jung, Peter Germano, Karthik Iyer, Timothy Claude Barden, Kim Tang
  • sGC STIMULATORS
    Publication number: 20170305878
    Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: February 17, 2017
    Publication date: October 26, 2017
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Charles KIM, Takashi NAKAI, Thomas Wai-Ho LEE, Joel MOORE, Nicholas Robert PERL, Jason ROHDE, Rajesh R. IYENGAR, Ara MERMERIAN, Angelika FRETZEN
  • sGC STIMULATORS
    Publication number: 20170298055
    Abstract: The present patent application discloses at least the compounds according to Formula Ia and Formula Ib shown below, or pharmaceutically acceptable salts thereof, wherein ring D, ring A, JB, n, J, RC1, RC2, Z1, Z2, W, X, Y1, Y2, JF and R9 are as defined herein.
    Type: Application
    Filed: September 16, 2015
    Publication date: October 19, 2017
    Applicant: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Glen Robert RENNIE, Nicholas PERL, Thomas Wai-Ho LEE, Paul Allan RENHOWE, Takashi NAKAI, Ara MERMERIAN, G-Yoon Jamie IM
  • PYRAZOLE DERIVATIVES AS SGC STIMULATORS
    Publication number: 20170291889
    Abstract: Compounds are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: September 16, 2015
    Publication date: October 12, 2017
    Applicant: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Timothy Claude BARDEN, James Edward SHEPPECK, Glen Robert RENNIE, Paul Allan RENHOWE, Nicholas PERL, Takashi NAKAI, Ara MERMERIAN, Thomas Wai-Ho LEE, Joon JUNG, James JIA, Karthik IYER, Rajesh R. IYENGAR, G-Yoon Jamie IM
  • sGC STIMULATORS
    Publication number: 20170291902
    Abstract: The present patent application discloses at least the compounds according to Formula I? shown below, or pharmaceutically acceptable salts thereof, wherein ring D, ring A, ring E, ring F, JB, n, JD, o, RC1, RC2, W, JE, r, JF, s, Z1, Z2 and Z3 are as defined herein.
    Type: Application
    Filed: September 16, 2015
    Publication date: October 12, 2017
    Applicant: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Nicholas PERL, Takashi NAKAI, Thomas Wai-Ho LEE, Glen Robert RENNIE, Paul Allan RENHOWE, Rajesh R. IYENGAR
  • sGC STIMULATORS
    Publication number: 20170137439
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: January 16, 2017
    Publication date: May 18, 2017
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG, Mark G. CURRIE
  • sGC STIMULATORS
    Publication number: 20170136019
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: January 16, 2017
    Publication date: May 18, 2017
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG, Mark G. CURRIE
  • sGC STIMULATORS
    Publication number: 20170112845
    Abstract: Compounds of Formula IA and Formula IB are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: May 31, 2016
    Publication date: April 27, 2017
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Charles KIM, Takashi NAKAI, Thomas Wai-Ho LEE, Joel MOORE, Nicholas Robert PERL, Jason ROHDE
  • sGC stimulators
    Patent number: 9586937
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: March 7, 2017
    Assignee: IRONWOOD PHARMACEUTICALS, INC.
    Inventors: Takashi Nakai, Joel Moore, Nicholas Robert Perl, Rajesh R. Iyengar, Ara Mermerian, G-Yoon Jamie Im, Thomas Wai-Ho Lee, Colleen Hudson, Glen Robert Rennie, James Jia, Paul Allan Renhowe, Timothy Claude Barden, Xiang Y. Yu, James Edward Sheppeck, Karthik Iyer, Joon Jung, George Todd Milne, Kimberly Kafadar Long, Mark G. Currie
  • sGC STIMULATORS
    Publication number: 20160375022
    Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
    Type: Application
    Filed: August 24, 2016
    Publication date: December 29, 2016
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Takashi NAKAI, Joel MOORE, Nicholas Robert PERL, Rajesh R. IYENGAR, Ara MERMERIAN, G-Yoon Jamie IM, Thomas Wai-Ho LEE, Colleen HUDSON, Glen Robert RENNIE, James JIA, Paul Allan RENHOWE, Timothy Claude BARDEN, Xiang Y. YU, James Edward SHEPPECK, Karthik IYER, Joon JUNG, George Todd MILNE, Kimberly Kafadar LONG, Mark G. CURRIE