Patents by Inventor Thomas Wais

Thomas Wais has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Azaindazole Compounds As CCR1 Receptor Antagonists
    Publication number: 20110086846
    Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
    Type: Application
    Filed: December 16, 2010
    Publication date: April 14, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Brian Nicholas COOK, Darren DiSALVO, Christian HARCKEN, Daniel KUZMICH, Thomas Wai-Ho LEE, Pingrong LIU, John LORD, Can MAO, Jochen NEU, Brian Christopher RAUDENBUSH, Hossein RAZAVI, Alan David SWINAMER
  • Azaindazole compounds as CCR1 receptor antagonists
    Patent number: 7879873
    Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: February 1, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Brian Nicholas Cook, Darren DiSalvo, Daniel Robert Fandrick, Christian Harcken, Daniel Kuzmich, Thomas Wai-Ho Lee, Pingrong Liu, John Lord, Can Mao, Jochen Neu, Brian Christopher Raudenbush, Hossein Razavi, Jonathan Timothy Reeves, Jinhua J. Song, Alan David Swinamer, Zhulin Tan
  • Azaindazole Compounds As CCR1 Receptor Antagonists
    Publication number: 20100093724
    Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
    Type: Application
    Filed: September 22, 2009
    Publication date: April 15, 2010
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Brian Nicholas COOK, Darren DiSALVO, Daniel Robert FANDRICK, Christian HARCKEN, Daniel KUZMICH, Thomas Wai-Ho LEE, Pingrong LIU, John LORD, Can MAO, Jochen NEU, Brian Christopher RAUDENBUSH, Hossein RAZAVI, Jonathan Timothy REEVES, Jinhua J. SONG, Alan David SWINAMER, Zhulin TAN
  • Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof
    Publication number: 20090325988
    Abstract: Compounds of Formula (I) wherein R1, R2, X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
    Type: Application
    Filed: June 3, 2009
    Publication date: December 31, 2009
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Christian Harcken, Rajashekhar Betageri, Todd Bosanac, Michael Jason Burke, Soojin Kim, Daniel Kuzmich, Thomas Wai-Ho Lee, Zhibin Li, Pingrong Liu, John Lord, Hossein Razavi, Jonathan Timothy Reeves, Daivd Thomson
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
    Patent number: 7579469
    Abstract: Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and X are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof, pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: August 25, 2009
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Daniel Kuzmich, Thomas Wai-Ho Lee, John Robert Proudfoot, John Robinson Regan, David S. Thomson, Abdelhakim Hammach, Mark Stephen Ralph, Renee Zindell, Younes Bekkali, Thomas Martin Kirrane, Jr.
  • GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
    Publication number: 20090176807
    Abstract: Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6 and X are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
    Type: Application
    Filed: March 16, 2009
    Publication date: July 9, 2009
    Inventors: John Robinson REGAN, Thomas Wai-Ho Lee, David Thomson, Thomas Martin Kirrane, JR., Daniel Kuzmich, John Robert Proudfoot, Younes Bekkali, Renee Zindell
  • Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
    Patent number: 7256300
    Abstract: A process for stereoselective synthesis of a compound of Formula (X) or Formula (X?) wherein R1, R2, and R3 are as defined herein, the process comprising: (a) reacting the starting material of formula A with a chiral sulfoxide anion source in a suitable solvent to prepare a compound of formula C or C?; (b) reducing the sulfoxide of formula C or C? in a suitable solvent to obtain the compound of formula D or D?; and (c) cyclizing the compound of formula D or D? in a suitable solvent to form the epoxide compound of Formula (X) or Formula (X?), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: August 14, 2007
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Thomas Wai-Ho Lee, John Robert Proudfoot
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
    Publication number: 20040162321
    Abstract: Compounds of Formula (I) 1
    Type: Application
    Filed: December 18, 2003
    Publication date: August 19, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Daniel Kuzmich, Thomas Wai-Ho Lee, John Robert Proudfoot, John Robinson Regan, David S. Thomson, Abdelhakim Hammach, Mark Stephen Ralph, Renee Zindell
  • Contact with exchangeable opto-electronic element
    Patent number: 4779948
    Abstract: Active special contact, adapted for insertion into a hybrid contact insert of a connector, the active contact including a housing, first contact elements disposed in the housing, a supporting element for receiving an electro-optic transducer, second contact elements disposed in the supporting element, means for the detachable connection of the housing and the supporting element, and means for releasably connecting the first and second contact elements.
    Type: Grant
    Filed: May 5, 1986
    Date of Patent: October 25, 1988
    Assignee: Amphenol Corporation
    Inventors: Thomas Wais, Werner G. Schrott
  • Connector for a fiber optic cable
    Patent number: 4733934
    Abstract: Cable connector for a fiber optic cable with at least one cable seating hole to receive at least one optic fiber coated with a jacket for the purpose of tension relieving and centering the optic fiber. At least one electro-optic transducer is housed in the cable connector.
    Type: Grant
    Filed: May 5, 1986
    Date of Patent: March 29, 1988
    Assignee: Amphenol Corporation
    Inventors: Thomas Wais, Werner G. Schrott