Abstract: Computer and mobile device-based systems and computer-implemented methods are described for automated medication adherence improvement for patients in medication-assisted treatments. The computer and mobile device-based systems includes modules and components to help patients in identifying prescribed medications, logging medication events, and to provide patients with personalized and targeted adherence enhancing interventions consisting of short questions, tips, advices, suggestions, strategies etc. by applying data mining and statistical analysis techniques on the individual and population-level data collected primarily from the same system.

Abstract: The present invention relates to methods of and apparatus for rapidly and accurately measuring the temperature of a small volume sample. The remote temperature sensor contains an optical interferometric sensor, preferably an extrinsic Fabry-Perot interferometer (EFPI), for measuring the difference in the distance traveled by a reference reflection and a sensing reflection. Because the refraction index of a solution is proportional to temperature, the output of the optical interferometric sensor can be converted to a temperature with a standard curve. Further, the present invention also provides methods and apparatus for measuring the temperature of the sample in performing non-contact (remote) thermocycling on small, micro to nanoliter, volume samples, wherein each cycle can be completed in as little as a few seconds.

Abstract: A body implantable sensor for sensing pressure in an environment within internal body tissue is described. In an implementation, the sensor includes a housing, an optical waveguide and a diaphragm with a reflective surface that faces a waveguide distal end and that reflects at least a portion of the signals exiting the waveguide distal end back into the waveguide. The diaphragm is movable relative to the waveguide end. The distance between the waveguide distal end and the diaphragm reflective surface is determined by pressure forces acting on a sensing surface of the diaphragm that is opposite the reflective surface. A cover surrounds the diaphragm and protects it from impingement, but leaves the diaphragm sensing surface exposed to pressure forces. In some implementations, an attachment mechanism stabilizes the sensor when implanted in the bodily tissue.