Patents by Inventor Thomas Wayne Bruice

Thomas Wayne Bruice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid ligand interaction assays
    Patent number: 6420109
    Abstract: Methods for determining the relative binding affinities of various ligands to various nucleic acid sequences are described. In a direct binding assay, the effect of adding increasing amounts of a ligand on a signal generated by two “indicator” oligonucleotides is observed. Also described is a competitive binding assay, in which a competitor oligonucleotide is added to an indicator duplex having a ligand bound thereto. The assays allow the rapid and convenient determination of nucleic acid binding specificities and base pair determinants of specificity of particular ligands.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: July 16, 2002
    Assignee: Genelabs Technologies, Inc.
    Inventors: Gary P. Schroth, Thomas Wayne Bruice, Young J. Suh
  • Nucleic acid ligand interaction assays
    Patent number: 6355428
    Abstract: Methods for determining the relative binding affinities of various ligands to various nucleic acid sequences, particularly in double stranded form, are described. In a direct binding assay, the effect of adding increasing amounts of a ligand on a signal generated by two “indicator” oligonucleotides is observed. Also described is a competitive binding assay, in which a competitor oligonucleotide is added to an indicator duplex having a ligand bound thereto. The assays allow the rapid and convenient determination of nucleic acid binding specificities and base pair determinants of specificity of particular ligands.
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: March 12, 2002
    Assignee: Genelabs Technologies, Inc.
    Inventors: Gary P. Schroth, Thomas Wayne Bruice, Young J. Suh