Patents by Inventor Thomas Wechsler

Thomas Wechsler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROLOGIC DISEASE
    Publication number: 20230330195
    Abstract: Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic IDUA or IDS protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for treatment and/or prevention of MPS I or MPS II disease.
    Type: Application
    Filed: October 24, 2022
    Publication date: October 19, 2023
    Inventors: Russell DeKelver, R. Scott McIvor, Li Ou, Thomas Wechsler, Chester B. Whitley, Kanut Laoharawee
  • METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED TARGETED INTEGRATION OF TRANSGENES INTO MAMMALIAN LIVER CELLS
    Publication number: 20230203540
    Abstract: Disclosed herein are methods and compositions for targeted, nuclease-mediated insertion of transgene sequences into the genome of a cell.
    Type: Application
    Filed: December 20, 2022
    Publication date: June 29, 2023
    Inventors: Michael C. Holmes, Thomas Wechsler
  • Method of making and using mammalian liver cells for treating hemophilia or lysosomal storage disorder
    Patent number: 11591622
    Abstract: Disclosed herein are methods and compositions for targeted, nuclease-mediated insertion of transgene sequences into the genome of a cell.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: February 28, 2023
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Michael C. Holmes, Thomas Wechsler
  • Pump guard and methods of use thereof
    Patent number: 11324976
    Abstract: A pump combination guard and methods of use thereof, having an inner housing or guard configured to cover mechanical seal assembly and the motor coupling housed between a drive motor and a fluid pump to enable foam spray nozzles to be directly inserted into the coupling guard housings for fire suppression and an outer “Air scoop” housing or guard configured to direct motor induced airflow over the mechanical seal assembly thereby enabling fire protection and cooling to extend seal life and to protect mechanical seals from pre-mature failure.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: May 10, 2022
    Assignee: WECHSLER ENGINEERING AND CONSULTING
    Inventor: Thomas Wechsler
  • METHODS AND COMPOSITIONS FOR GENOME ENGINEERING
    Publication number: 20210188926
    Abstract: Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease.
    Type: Application
    Filed: March 1, 2021
    Publication date: June 24, 2021
    Inventors: Jeffrey C. Miller, David Paschon, Edward J. Rebar, Thomas Wechsler, Lei Zhang
  • Methods and compositions for genome engineering
    Patent number: 10968261
    Abstract: Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: April 6, 2021
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Jeffrey C. Miller, David Paschon, Edward J. Rebar, Thomas Wechsler, Lei Zhang
  • Methods and compositions for enhancing targeted transgene integration
    Patent number: 10889834
    Abstract: Disclosed herein are methods and compositions for enhancing insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease or a hemophilia by administering one or more topoisomerases inhibitors, one or more stabilizers of R loop formation or inhibitors of R-loop repair and/or one or more up-regulators of the TC-NER pathway to the target cell.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: January 12, 2021
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Gregory J. Cost, Thomas Wechsler
  • PUMP GUARD AND METHODS OF USE THEREOF
    Publication number: 20200222734
    Abstract: A pump combination guard and methods of use thereof, having an inner housing or guard configured to cover mechanical seal assembly and the motor coupling housed between a drive motor and a fluid pump to enable foam spray nozzles to be directly inserted into the coupling guard housings for fire suppression and an outer “Air scoop” housing or guard configured to direct motor induced airflow over the mechanical seal assembly thereby enabling fire protection and cooling to extend seal life and to protect mechanical seals from pre-mature failure.
    Type: Application
    Filed: February 12, 2018
    Publication date: July 16, 2020
    Inventor: Thomas WECHSLER
  • DELIVERY METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED GENOME ENGINEERING
    Publication number: 20200102577
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a cell.
    Type: Application
    Filed: September 6, 2019
    Publication date: April 2, 2020
    Inventors: GARY K. LEE, Brigit E. Riley, Susan J. St. Martin, Thomas Wechsler
  • METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED TARGETED INTEGRATION
    Publication number: 20190352671
    Abstract: Disclosed herein are methods and compositions for targeted, nuclease-mediated insertion of transgene sequences into the genome of a cell.
    Type: Application
    Filed: August 5, 2019
    Publication date: November 21, 2019
    Inventors: Michael C. Holmes, Thomas Wechsler
  • Delivery methods and compositions for nuclease-mediated genome engineering
    Patent number: 10450585
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a cell.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: October 22, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Gary K. Lee, Brigit E. Riley, Susan J. St. Martin, Thomas Wechsler
  • Method of treating factor IX deficiency using nuclease-mediated targeted integration
    Patent number: 10370680
    Abstract: Disclosed herein are methods and compositions for targeted, nuclease-mediated insertion of transgene sequences into the genome of a cell.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: August 6, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Michael C. Holmes, Thomas Wechsler
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF RARE DISEASES
    Publication number: 20190167815
    Abstract: The present disclosure is in the field of modulation of genes involved in rare diseases including for diagnostics and therapeutics for rare diseases such as Angelman's Syndrome, Facioscapulohumeral Muscular Dystrophy (FHMD), Amyotrophic Lateral Sclerosis (ALS), Frontotemporal dementia (FTD) and Spinal Muscular Atrophy (SMA).
    Type: Application
    Filed: October 24, 2018
    Publication date: June 6, 2019
    Inventors: Michael C. Holmes, Brigit E. Riley, Thomas Wechsler, Bryan Zeitler, Lei Zhang
  • Methods and compositions for enhancing nuclease-mediated gene disruption
    Patent number: 10227610
    Abstract: Methods and compositions for increasing nuclease-mediated genomic modification using DNA repair inhibitors are provided.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: March 12, 2019
    Assignees: Sangamo Therapeutics, Inc., Sigma Aldrich Co LLC
    Inventors: Fuqiang Chen, Qiaohua Kang, Thomas Wechsler
  • METHODS AND COMPOSITIONS FOR GENOME ENGINEERING
    Publication number: 20180362601
    Abstract: Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease.
    Type: Application
    Filed: August 21, 2018
    Publication date: December 20, 2018
    Inventors: Jeffrey C. Miller, David Paschon, Edward J. Rebar, Thomas Wechsler, Lei Zhang
  • Methods and compositions for genome engineering
    Patent number: 10081661
    Abstract: Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: September 25, 2018
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Jeffrey C. Miller, David Paschon, Edward J. Rebar, Thomas Wechsler, Lei Zhang
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROLOGIC DISEASE
    Publication number: 20170202931
    Abstract: Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic IDUA or IDS protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for treatment and/or prevention of MPS I or MPS II disease.
    Type: Application
    Filed: January 12, 2017
    Publication date: July 20, 2017
    Inventors: Russell DeKelver, R. Scott McIvor, Li Ou, Thomas Wechsler, Chester B. Whitley
  • DELIVERY METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED GENOME ENGINEERING
    Publication number: 20170016027
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a cell.
    Type: Application
    Filed: July 13, 2016
    Publication date: January 19, 2017
    Inventors: Gary K. Lee, Brigit E. Riley, Susan J. St. Martin, Thomas Wechsler
  • METHODS AND COMPOSITIONS FOR ENHANCING TARGETED TRANSGENE INTEGRATION
    Publication number: 20160168593
    Abstract: Disclosed herein are methods and compositions for enhancing insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease or a hemophilia by administering one or more topoisomerases inhibitors, one or more stabilizers of R loop formation or inhibitors of R-loop repair and/or one or more up-regulators of the TC-NER pathway to the target cell.
    Type: Application
    Filed: December 14, 2015
    Publication date: June 16, 2016
    Inventors: Gregory J. Cost, Thomas Wechsler
  • METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED TARGETED INTEGRATION
    Publication number: 20150240263
    Abstract: Disclosed herein are methods and compositions for targeted, nuclease-mediated insertion of transgene sequences into the genome of a cell.
    Type: Application
    Filed: February 24, 2015
    Publication date: August 27, 2015
    Inventors: Michael C. Holmes, Thomas Wechsler