Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

Abstract: A computer program for spine mobility simulation is configured, if running on a computer, to cause the computer to perform the following steps: a) accessing bio-metric data which relate to the spine of a patient, the spine having at least one compromised spine segment; b) displaying a model of the spine of the patient comprising a plurality of vertebrae; c) enabling a user to change the position of at least one of the vertebrae of the spine model; d) computing the effects of the position change on the remaining vertebrae; e) displaying the spine model in a new configuration, thereby taking into account the position changed by the user in step c) and the position changes of the remaining vertebrae computed in step d).

Abstract: A mower for harvesting crop includes windrow forming housing where crop is discharged after being cut. A windrow grouper attachment includes a crop conveyor attached to the main frame of the mower by a vertically swingable support which is selectively disposable in a lowered working position where it intercepts crop exiting the windrow forming housing and transfers it side ways and in a raised non-use position wherein it permits crop exiting from the mower to be deposited into a windrow directly behind the mower. The vertically swingable support for the crop conveyor is mounted to a slide that is in turn mounted for shifting laterally on a transverse beam of the mower main frame. By selectively manipulating the conveyor among its working, non-use and shifted positions, it is possible to deposit three windrows alongside each other for being subsequently picked up together for processing by another machine, such as an ensilage harvester, for example.