Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.

Abstract: In general, the present disclosure is directed to systems and methods of evaluating a subject's risk of one or more complications associated with pelvic organ prolapse surgery. The method comprising: obtaining, by a computing system comprising one or more computing devices, sample data associated with the subject; inputting, by the computing system, the sample data into a machine-learned immune response model; receiving, by the computing system as an output of the machine-learned immune response model, one or more predictions of post-surgical complications of mesh exposure through the vaginal wall associated with the subject; and performing a pelvic organ prolapse repair surgery on the subject, wherein the surgery is performed based at least in part on the one or more predictions of post-surgical complications by the machine-learned immune response model associated with a likelihood of success.

Abstract: Techniques for radioablation of sympathetic nerves include positioning a subject on a support in view of a volume imaging system and an ionizing radiation source; and collecting volume image data. Location of a treatment portion of a sympathetic nerve in the subject is determined based on the volume image data. Movement of the source is determined to apply a therapeutic radiation dose to the treatment portion based on the location of the treatment portion and relative location of the source to the volume imaging system. The source is operated to deliver the therapeutic radiation dose. An apparatus includes a mounting structure, an X-ray source and a shield. The source produces an X-ray beam with photon energy above one million electron volts (MeV) and not above six MeV. The shield is mounted in opposition to the source to block the X-ray beam with photon energies not greater than about six MeV.

Abstract: In an application, variants of a class may be generated and associated with different security permissions for the application. When a class is to be loaded, a determination is made as to the application's security permissions, e.g. by decoding a security token. The class is then retrieved from a repository that stores class variants matching the required security level. The retrieved class variant, which may have a full or a reduced functionality as appropriate for the security permission may then by loaded.

Abstract: In an application, variants of a class may be generated and associated with different security permissions for the application. When a class is to be loaded, a determination is made as to the application's security permissions, e.g. by decoding a security token. The class is then retrieved from a repository that stores class variants matching the required security level. The retrieved class variant, which may have a full or a reduced functionality as appropriate for the security permission may then by loaded.

Abstract: In an application, variants of a class may be generated and associated with different security permissions for the application. When a class is to be loaded, a determination is made as to the application's security permissions, e.g. by decoding a security token. The class is then retrieved from a repository that stores class variants matching the required security level. The retrieved class variant, which may have a full or a reduced functionality as appropriate for the security permission may then by loaded.

Abstract: A method and apparatus are disclosed that calculate an area-of-interest based on a user request for location specific data. The operations may include transmitting initial location data of the mobile terminal and user initiated gesture data to a server. The server may then perform initiating a request to receive the requested location data, and calculating a geographical area-of-interest based on the initial location data and the user initiated gesture data. The location specific data related to the area-of-interest may then be retrieved and transmitted to the mobile terminal. The area-of-interest may be defined based on the initial position of the mobile terminal and information provided by a gesture made by the user of the mobile terminal.

Abstract: A message encoding specification and implementation where a receiver of an encoded message determines if the message can be decoded. If the receiver can decode the message, it does so and continues processing the message. If the receiver cannot decode the message, it returns a distinguished failure message to the sender, expecting the sender to resend the message using a different encoding scheme. When a sender receives the distinguished failure message that the receiver cannot decode the message, the sender encodes the message using an alternate encoding scheme, if one is available, and resends the message. The process continues until the sender has tried all available encoding schemes. If a sender exhausts the collection of available encoding schemes without finding one the receiver can successfully decode, the sender treats the failure as an error.

Abstract: Techniques for radioablation of sympathetic nerves include positioning a subject on a support in view of a volume imaging system and an ionizing radiation source; and collecting volume image data. Location of a treatment portion of a sympathetic nerve in the subject is determined based on the volume image data. Movement of the source is determined to apply a therapeutic radiation dose to the treatment portion based on the location of the treatment portion and relative location of the source to the volume imaging system. The source is operated to deliver the therapeutic radiation dose. An apparatus includes a mounting structure, an X-ray source and a shield. The source produces an X-ray beam with photon energy above one million electron volts (MeV) and not above six MeV. The shield is mounted in opposition to the source to block the X-ray beam with photon energies not greater than about six MeV.

Abstract: Embodiments of the present invention provide apparatuses and methods for a capacity model run-time estimator that determines the transactional capacity of an application. The capacity model run-time estimator is based on a model that includes at least one job with various steps within a run-time window. One or more windows make up shifts and one or more shifts make up a day. Historical data is used to estimate various run-times for each of the steps in a window. If the steps are dependent on transaction characteristics a statistical analysis is used to determine a run-time window estimator model that is dependent on the transaction characteristics. Constraints are placed on the run-time and transaction capacity of the windows, intra-windows, and shifts. The capacity model uses the run-time window estimators and constraints to determine the transaction capacity for an application across various periods and compares the results to forecasted capacity.

Abstract: A message encoding specification and implementation where a receiver of an encoded message determines if the message can be decoded. If the receiver can decode the message, it does so and continues processing the message. If the receiver cannot decode the message, it returns a distinguished failure message to the sender, expecting the sender to resend the message using a different encoding scheme. When a sender receives the distinguished failure message that the receiver cannot decode the message, the sender encodes the message using an alternate encoding scheme, if one is available, and resends the message. The process continues until the sender has tried all available encoding schemes. If a sender exhausts the collection of available encoding schemes without finding one the receiver can successfully decode, the sender treats the failure as an error.

Abstract: In an application, variants of a class may be generated and associated with different security permissions for the application. When a class is to be loaded, a determination is made as to the application's security permissions, e.g. by decoding a security token. The class is then retrieved from a repository that stores class variants matching the required security level. The retrieved class variant, which may have a full or a reduced functionality as appropriate for the security permission may then by loaded.

Abstract: A method and apparatus are disclosed that calculate an area-of-interest based on a user request for location specific data. The operations may include transmitting initial location data of the mobile terminal and user initiated gesture data to a server. The server may then perform initiating a request to receive the requested location data, and calculating a geographical area-of-interest based on the initial location data and the user initiated gesture data. The location specific data related to the area-of-interest may then be retrieved and transmitted to the mobile terminal. The area-of-interest may be defined based on the initial position of the mobile terminal and information provided by a gesture made by the user of the mobile terminal.

Abstract: A method for fastening two or more steel framing members together with a fastener. The fastening technique employs a fastener having a coil section with an elastic characteristic.

Abstract: A hangtag is provided that is capable of hanging and securing a tool, such as a socket. The hangtag has a body portion having a front surface and a back surface, a hanging mechanism connected to the body portion, and a tool supporting mechanism also connected to the body portion for supporting a tool. The tool supporting mechanism includes first and second legs and a locking finger disposed between the first and second legs. The locking mechanism allows the particular tool to be reattached to the hangtag assembly after it is initially unlocked. This allows the hangtag to function as a storage and organization device for the tool.

Abstract: A hangtag is provided that is capable of hanging multiple tools. The hangtag has a body portion, a hanging mechanism connected to the body portion, and a tool supporting mechanism also connected to the body portion for supporting a tool. The body portion has a front surface and a back surface. On the back surface is disposed a hangtag attachment apparatus. The hangtag attachment apparatus comprises a bracket, and an elongated attachment bar configured to be selectively attached to and detached from the bracket. The attachment bar has a length that permits it to be connected to at least two and preferably more hangtags so that multiple hangtags may be selectively connected together. In this way, tools that would otherwise be sold individually can now be sold as a set.

Abstract: The present invention discloses a workshop unit for use as a grinding center that includes a support frame having a drive motor and a multi-station tool mounted thereto. Particularly, the grinding center may be used for operations including but not limited to grinding, buffing, polishing, sanding, and cleaning. The multi-station tool includes a plurality of rotary tools, a power transfer system, and a rotary tool selecting system. The power transfer system operates through a plurality of pulleys each in communication with at least one rotary tool and the drive motor through a plurality of transmission links. The rotary tool selecting system, which includes one or more control shafts and a clutch system, allows each tool to be selectively and independently operated.

Abstract: A method and apparatus for clamping a work piece is disclosed. The apparatus generally includes a stationary jaw disposed on a bar and having a first clamping surface and a moveable jaw disposed on the bar and having a second clamping surface. The apparatus further comprises a drive handle which provides movement of the moveable jaw relative to the bar. The drive handle can be configured to move the second clamping surface at different rates and forces when operated.

Abstract: A fastening tool including a contact trip mechanism having a trigger block. The contact trip mechanism is moveable to a retracted position. The fastening tool also includes a slider member connected to the trigger block and a link member adjustably coupled to the slider member. The fastening tool further includes a lockout pin movable between a first position and a second position. The lockout pin in the first position decouples the slider member and the link member and holds the trigger block in a blocked position.

Abstract: A fastening tool that inserts a fastener into a work-piece includes a trigger and an actuation member connected to the trigger. The fastening tool further includes a trigger switch and a trigger block. The trigger block has a blocked position that inhibits the actuation member from actuating the trigger switch. The trigger block also has an unblocked position that does not inhibit the actuation member from actuating the trigger switch. The mechanical contact trip mechanism provides a contact trip without the need for additional switches and a complicated trigger assembly.