Abstract: Dermal neurofibroma, in particular Neurofibromatosis Type I (NF1) leads to progressive tumor proliferation with no known mechanism to inhibit growth. The present invention relates to the use of photodynamic therapy (PDT) for attenuating tumor growth in NF1 patients. More particularly the invention provides a method of treating dermal neurofibroma comprising topically applying a pharmaceutical composition comprising a photosensitizer to the affected area of a patient, incubating the affected area, and irradiating the affected area with a light of suitable wavelength as per the photosensitizer used, wherein the treatment is characterized by inhibiting the progression of tumor growth and/or reduction in tumor size and/or increased mortality rate of the neurofibroma cell.

Abstract: Certain examples described herein relate to modelling a three-dimensional space. Image data from at least one capture device is used to generate a three-dimensional model of the three-dimensional space. In certain examples, the three-dimensional model is segmented into active and inactive portions based on at least one model property. The examples are configured to use the active portions to update the three-dimensional model over time. Registration is also performed to align active portions of the three-dimensional model with inactive portions of the three-dimensional model over time. The registration aligns active portions of the three-dimensional model generated following an observation of a region of the three-dimensional space with inactive portions of the model generated following at least one previous observation of said region.

Abstract: Certain examples described herein relate to modelling a three-dimensional space. Image data from at least one capture device is used to generate a three-dimensional model of the three-dimensional space. In certain examples, the three-dimensional model is segmented into active and inactive portions based on at least one model property. The examples are configured to use the active portions to update the three-dimensional model over time. Registration is also performed to align active portions of the three-dimensional model with inactive portions of the three-dimensional model over time. The registration aligns active portions of the three-dimensional model generated following an observation of a region of the three-dimensional space with inactive portions of the model generated following at least one previous observation of said region.

Abstract: The disclosed embodiments provide a system for processing data. During operation, the system inputs a set of features for a customer of a product into a first statistical model, wherein the set of features comprises a company segment of the customer. Next, the system uses the first statistical model to predict a churn risk of the customer. When the churn risk exceeds a first threshold for the company segment, the system outputs a notification of a high churn risk level for the customer.

Abstract: The disclosed embodiments provide a system for processing data. During operation, the system obtains a set of data for a set of customers of a product, wherein the set of data comprises a set of churn risk levels for the customer. Next, the system uses the set of data to display a graphical user interface (GUI) comprising a chart of renewal opportunities with the set of customers, for the product, over an upcoming time interval. The system then displays, in the GUI, a representation of a churn risk level for each customer in the set of customers with a renewal opportunity in the chart.

Abstract: A computer system is provided for selecting an asset allocation for an investment portfolio intended to produce a target payout starting at a target date. The computer system is programmed to receive inputs that may relate to the target payout, the target date and a nominal rate of contributions to the investment portfolio. The computer system calculates at least one thousand simulated investment outcomes based on assumed investment return rates and assumed inflation rates. The assumed investment return rates and assumed inflation rates are randomly selected in multi-year clusters from historical data. The computer system selects the asset allocation based on relative performance of the assumed asset allocations in the simulated investment outcomes.

Abstract: A wheelchair seat cushion has multi-density regions. The cushion assembly may have a region having a stiffer, higher density proximate the front of the seat cushion assembly beneath the user's thighs to assist the user in exiting the wheelchair. Alternatively, or additionally, an insert member having multi-density regions may be received in a recess in a base member. The insert members may be oriented in different orientations to position a softer, less dense region at different locations, to situate the softer, less dense region of the insert beneath a particular user's ischial tuberosities and/or coccyx.

Abstract: A system and method for providing a dose of irradiating light for a therapeutic process includes identifying an internal target area of a patient affected by a pathology and irradiating an externally accessible area of the patient proximate to the internal target area with a number of photons at least having wavelengths approximately within a near-infrared (IR) band. The method also includes receiving feedback from one of a spectrophotometer and a patient physiology monitoring system and adjusting the number of photons irradiating the externally accessible area of the patient. From the feedback, a determination is made to identify the number of photons needed to irradiate the externally accessible area of the patient to cause a change in biochemical state of cytochrome oxidase in the internal target area to a desired biochemical state of cytochrome oxidase in the internal target area.

Abstract: A seat assembly can be mounted on various wheelchair bases. The seat assembly enables the seat width and backrest width to be adjusted independently of each other. A backrest has a plurality of open slots, the number and orientation of which contributes to depth, width, and height adjustment of the backrest as well as angular adjustment of lateral supports to permit the backrest to conform to the anatomical curves of a user. A backrest foam assembly comprises multiple foam sections that are adapted to be positioned relative to each other and thereby vary the overall width of the assembly. A cover comprises multiple sections, each covering a foam section. A multi-position adjustable armrest assembly combines large-scale and small-scale adjustments, which provides a broad range of adjustment for the armrest and its position. A power recline mechanism with programmable shear reduction includes a dual rotary recline mechanism.

Abstract: The vehicle comprises a base and a seat moveable along a curve having a focal point. The vehicle is adjustable to position an occupant in the seat to achieve a desired position for the center of gravity of the occupant relative to the focal point of the curve. A method for minimizing effort required to tilt the seat of a personal mobility vehicle comprises the steps of providing a personal mobility vehicle having a seat that is adapted to move along an arc having a center of curvature, positioning the seat substantially horizontally, providing an occupant in the seat, and adjusting the position of the vehicle occupant's center of gravity so that the center of gravity is substantially equal to or below the center of curvature of the arc.

Abstract: A seat cushion includes a cushion base, a pressure-distributing medium, and a cover. The base supports the pressure-distributing medium. The cover has a pocket for receiving the pressure-distributing medium and covers the base and the pressure-distributing medium therein. A method for carrying the pressure-distributing medium in a personal mobility vehicle cushion comprises the steps of providing a cushion cover having a pocket, inserting a pressure-distributing medium in the pocket, and inserting a base in the cover so that the pressure-distributing medium is positioned above the base.