Abstract: A N2O decomposition reactor and a method of its use to produce an effluent suitable for use in an ignition device or in the main fuel injection system in high speed aircraft. N2O decomposition is an exothermic reaction and produces a high temperature product containing high concentrations of O2. Combination of fuel with this effluent ignites quickly and is an effective ignition source for the aircraft combustor. Reactor performance is adjusted to meet the conditions required for a selected application by changing the relative concentrations of CO2 and N2O, modifying the reactor length, and varying the quantity of catalyst in the reactor. For use in a pilot ignition device, the desired effluent temperature is between 500° C. and 1200° C. in order to ignite and combust the fuel within the design residence time, between 0.5 and 10 ms. For application as a barbotage gas generator in a fuel injection system, the temperature of the effluent can range from 300° C. up to 800° C.

Abstract: A golf alignment device for use in adjustment of golf stance and golf swing and used to train a user to properly position his/her feet (stance) and the golf club (aim, ball and club head position) when hitting a golf shot. The device includes components for measurement of distance and orientation, including the position of the shoes with respect to each other, the position and/or orientation of the golf club head of the golf club being held by the user and position of the golf ball intended to be struck by the user relative to the device. The alignment device allows determination of the aim of the user as determined by the position of his/her feet as well as the orientation of the golf club head face. A method is also provided for measurement of and adjustment of a golfer's stance and golf swing. This method can be employed in training a golfer and during golf practice.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.

Abstract: Endothermic fuel compositions comprising 50% or more by volume decahydronaphthalene, including cis-decahydronaphthalene, trans-decahydronaphthalene or a mixture thereof, for use as endothermic fuels in hypersonic vehicles and particularly for use in dual-mode ramjet or supersonic combustion ramjet air breathing engines. Methods for operating a ramjet or scram jet engine wherein the endothermic fuel is used for cooling the combustor and for combustion in the combustor.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.

Abstract: Described herein are novel preparations of functionalized erythroid cells and related compositions, reagents, and methods for use in human pharmaceutical and veterinary applications.

Abstract: Endothermic fuel compositions comprising 50% or more by volume decahydronaphthalene, including cis-decahydronaphthalene, trans-decahydronaphthalene or a mixture thereof, for use as fuels in hypersonic vehicles and particularly for use in dual-mode ramjet or supersonic combustion ramjet air breathing engines.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.

Abstract: A system including a catalytic heat exchanger reactor configured to carry out exothermic decomposition of stable chemical species possessing positive heats of formation. In an embodiment, the reactor is configured to enhance decomposition reaction rates by contacting gas entering with a hot surface. The catalytic heat exchanger is configured to receive N2O and create N2 and O2. A torch is created by fuel together with the hot N2 and the O2. In an embodiment, the reactor is configured to, after an initial period of time, to allow a rapid transfer of products of the decomposition reaction into an engine. In an embodiment, the reactor is configured to enhance decomposition reaction rates by contacting gas entering with a hot surface, and the catalytic heat exchanger reactor is configured to promote the atomization and vaporization of liquid and gelled fuels with gas. Other embodiments are also disclosed.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.

Abstract: The present invention relates to a novel composition useful in targeted diagnostic and/or therapy of a target site, such as cancerous tissue. The composition and methods disclosed herein find particular use in diagnosing and imaging cancerous tissue. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique.

Abstract: Methods for treating cancer patients with HER2-positive tumors are disclosed. The methods comprise administering to a patient a therapeutically effective amount of a combination of (i) an anthracycline-loaded immunoliposome with a targeting moiety that is a first anti-HER2 antibody and (ii) an anti-cancer therapeutic comprising a second anti-HER2 antibody.