Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Vehicle snow and ice removers are disclosed. An example vehicle and ice remover includes a plurality of first modular frames, where the first modular frames have a first shape and a plurality of second modular frames, where the second modular frames have a second shape different than the first shape. The first modular frames and the second modular frames are connected to form a first side frame, a second side frame opposite the first side frame, and a cross frame connecting the first side frame and the second side frame.

Abstract: A vehicle snow and ice remover comprises a plurality of modular pieces assembled together to form a pair of vertical supports and a cross piece connecting the pair of vertical supports and a roof clearing device movable along the pair of vertical supports. The plurality of modular pieces include at most two different shapes and each having a maximum outer dimension that is less than or equal to 75% of a height of each of the vertical supports.

Abstract: A vehicle snow and ice remover comprises a plurality of modular pieces assembled together to form a pair of vertical supports and a cross piece connecting the pair of vertical supports and a roof clearing device movable along the pair of vertical supports. The plurality of modular pieces include at most two different shapes and each having a maximum outer dimension that is less than or equal to 75% of a height of each of the vertical supports.

Abstract: Disclosed is a video magnifier. In particular, the disclosure relates to a desktop video magnifier that is design to be portable. The magnifier includes a high definition camera that is mounted upon a flexible arm. The camera arm swivels and pivots to allow the user to properly position the camera over the object to be viewed. The device is supported by a stand and a base. The stand includes a handle with a trough. The flexible arm is dimensioned to be received within the trough with the device in the collapsed configuration.

Abstract: A mixing and dispensing device comprising an outer casing including a body portion, a handle portion, and a nozzle portion with a nozzle. A mixing manifold disposed in the body portion including a mixing chamber in fluid communication with the nozzle. Canisters within the body portion each including a valve connected to the mixing manifold movable between preventing and providing fluid communication between the canister and the mixing chamber. A trigger disposed within the handle portion and configured to move from a trigger passive to dispensing position causing the valves of each canister to move from a valve passive position to the valve dispensing position. A pull safety including a central cover and a tail tip removably disposed on the outer casing such that the central cover occludes the nozzle and the tail tip prevents movement of the trigger from the trigger passive position to the trigger dispensing position.

Abstract: A mixing and dispensing device comprising an outer casing including a body portion, a handle portion, and a nozzle portion with a nozzle. A mixing manifold disposed in the body portion including a mixing chamber in fluid communication with the nozzle. Canisters within the body portion each including a valve connected to the mixing manifold movable between preventing and providing fluid communication between the canister and the mixing chamber. A trigger disposed within the handle portion and configured to move from a trigger passive to dispensing position causing the valves of each canister to move from a valve passive position to the valve dispensing position. A pull safety including a central cover and a tail tip removably disposed on the outer casing such that the central cover occludes the nozzle and the tail tip prevents movement of the trigger from the trigger passive position to the trigger dispensing position.

Abstract: Disclosed is a video magnifier. In particular, the disclosure relates to a desktop video magnifier that is design to be portable. The magnifier includes a high definition camera that is mounted upon a flexible arm. The camera arm swivels and pivots to allow the user to properly position the camera over the object to be viewed. The device is supported by a stand and a base. The stand includes a handle with a trough. The flexible arm is dimensioned to be received within the trough with the device in the collapsed configuration.