Patents by Inventor Thomas Wissel

Thomas Wissel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Iron chelator-containing prothrombin time reagent
    Patent number: 11774461
    Abstract: The present invention pertains to the field of coagulation diagnostics and relates to a prothrombin time reagent on the basis of recombinant or native tissue factor protein and phospholipids, which reagent can be stabilized by the addition of an iron chelator from the groups of siderophores and 3,5-diphenyl-1,2,4-triazoles.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: October 3, 2023
    Assignee: Siemens Healthcare Diagnostics Products GMBH
    Inventors: Sabine Pilgrim, Thomas Wissel, Norbert Zander
  • IRON CHELATOR-CONTAINING PROTHROMBIN TIME REAGENT
    Publication number: 20200371119
    Abstract: The present invention pertains to the field of coagulation diagnostics and relates to a prothrombin time reagent on the basis of recombinant or native tissue factor protein and phospholipids, which reagent can be stabilized by the addition of an iron chelator from the groups of siderophores and 3,5-diphenyl-1,2,4-triazoles.
    Type: Application
    Filed: November 27, 2018
    Publication date: November 26, 2020
    Inventors: Sabine PILGRIM, Thomas WISSEL, Norbert ZANDER
  • Method of determining inhibitors of coagulation
    Patent number: 8889370
    Abstract: A homogeneous method of determining inhibitors of proteolytically active coagulation factors (anticoagulants) in a sample, in particular direct thrombin and factor Xa inhibitors, and also a test kit to be used in such a method. Use is made of ligands which bind to the proteolytically active coagulation factor but are not cleaved by the latter and compete with the anticoagulant to be determined.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: November 18, 2014
    Assignee: Siemens Healthcare Diagnostics Products GmbH
    Inventors: Andreas Kappel, Andreas Rechner, Sina Stephan, Thomas Wissel
  • METHOD FOR DETERMINING PROTEIN S ACTIVITY
    Publication number: 20140242621
    Abstract: The invention relates to a method for determining the protein Ca-cofactor activity of protein S, wherein the protein Ca-cofactor activity of protein S is measured in a first reaction volume in the absence of a protein S inhibitor and in a second reaction volume in the presence of a protein S inhibitor. The protein Ca-cofactor activity of protein S is determined by calculating the quotient of the assay result of the first reaction volume and the assay result of the second reaction volume.
    Type: Application
    Filed: February 12, 2014
    Publication date: August 28, 2014
    Applicant: Siemens Healthcare Products Diagnostics GmbH
    Inventors: Juergen Patzke, Joern Meuer, Thomas Wissel
  • Method of Determining Inhibitors of Coagulation
    Publication number: 20120171697
    Abstract: A homogeneous method of determining inhibitors of proteolytically active coagulation factors (anticoagulants) in a sample, in particular direct thrombin and factor Xa inhibitors, and also a test kit to be used in such a method. Use is made of ligands which bind to the proteolytically active coagulation factor but are not cleaved by the latter and compete with the anticoagulant to be determined.
    Type: Application
    Filed: December 21, 2011
    Publication date: July 5, 2012
    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH
    Inventors: Andreas Kappel, Andreas Rechner, Sina Stephan, Thomas Wissel
  • Peptides with the marburg I polymorphism of factor VII-activating protease (FSAP) and their preparation and uses
    Patent number: 7951910
    Abstract: The invention relates to peptides with the Marburg I polymorphism of FSAP and to their preparation and uses, in particular in therapy and diagnosis. The peptides are suitable for use as immunizing antigens for preparing FSAP MR I specific antibodies.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: May 31, 2011
    Assignee: Siemens Healthcare Diagnostics Products GmbH
    Inventors: Herbert Schwarz, Harald Althaus, Bodo Fischer, Thomas Wissel
  • ANTIBODIES WHICH ARE DIRECTED AGAINST THE MARBURG I POLYMORPHISM OF FACTOR VII-ACTIVATING PROTEASE (FSAP), AND THEIR PREPARATION AND USE
    Publication number: 20100145009
    Abstract: The invention relates to antibodies which are directed against the FSAP Marburg I variant and to their preparation and use, in particular in therapy and diagnosis. The antibodies are characterized by the fact that they bind specifically to the FSAP MR I variant but not to the FSAP wild-type protein or other mutant variants which are characterized by amino acid substitutions at other positions in the FSAP protein.
    Type: Application
    Filed: October 13, 2009
    Publication date: June 10, 2010
    Inventors: Herbert SCHWARZ, Harald ALTHAUS, Bodo Fischer, Thomas WISSEL
  • Methods for determination of an analyte
    Patent number: 7700298
    Abstract: The invention relates to analytical methods in which the partition of a labeled substance between a liquid and a solid phase is determined. The assays include solid-phase reagents which can be particulate or monolithic such as, for example, a coated tube. Assays of this type are known per se to the person skilled in the art and include immunoassays and immunometric assays.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: April 20, 2010
    Assignee: Siemens Healthcare Diagnostics Products GmbH
    Inventor: Thomas Wissel
  • Antibodies which are directed against the Marburg I polymorphism of factor VII-activating protease (FSAP), and their preparation and use
    Patent number: 7622558
    Abstract: The invention relates to antibodies which are directed against the FSAP Marburg I variant and to their preparation and use, in particular in therapy and diagnosis. The antibodies are characterized by the fact that they bind specifically to the FSAP MR I variant but not to the FSAP wild-type protein or other mutant variants which are characterized by amino acid substitutions at other positions in the FSAP protein.
    Type: Grant
    Filed: August 23, 2005
    Date of Patent: November 24, 2009
    Assignee: Siemens Healthcare Diagnostics Products GmbH
    Inventors: Herbert Schwarz, Harald Althaus, Bodo Fischer, Thomas Wissel
  • Methods for determination of an analyte
    Publication number: 20070026459
    Abstract: The invention relates to analytical methods in which the partition of a labeled substance between a liquid and a solid phase is determined. The assays include solid-phase reagents which can be particulate or monolithic such as, for example, a coated tube. Assays of this type are known per se to the person skilled in the art and include immunoassays and immunometric assays.
    Type: Application
    Filed: February 16, 2006
    Publication date: February 1, 2007
    Inventor: Thomas Wissel
  • Methods for determination of an analyte
    Patent number: 7029856
    Abstract: The invention relates to analytical methods in which the partition of a labeled substance between a liquid and a solid phase is determined. The assays include solid-phase reagents which can be particulate or monolithic such as, for example, a coated tube. Assays of this type are known per se to the person skilled in the art and include immunoassays and immunometric assays.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 18, 2006
    Assignee: Dade Behring Marburg GmbH
    Inventor: Thomas Wissel
  • Antibodies which are directed against the Marburg I polymorphism of factor VII-activating protease (FSAP), and their preparation and use
    Publication number: 20060045879
    Abstract: The invention relates to antibodies which are directed against the FSAP Marburg I variant and to their preparation and use, in particular in therapy and diagnosis. The antibodies are characterized by the fact that they bind specifically to the FSAP MR I variant but not to the FSAP wild-type protein or other mutant variants which are characterized by amino acid substitutions at other positions in the FSAP protein.
    Type: Application
    Filed: August 23, 2005
    Publication date: March 2, 2006
    Inventors: Harald Althaus, Herbert Schwarz, Bodo Fischer, Thomas Wissel
  • Increasing the FVII sensitivity of a thromboplastin reagent
    Patent number: 6376209
    Abstract: The present invention relates to a process for increasing the FVII sensitivity of a thromboplastin reagent by means of heat treatment.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: April 23, 2002
    Assignee: Dade Behring Marburg GmbH
    Inventors: Thomas Wissel, Hermann Keuper, Hubert Nettelhoff, Heinz-Georg Kandel, Reiner Muth, Michael Kraus
  • INCREASING THE FVII SENSITIVITY OF A THROMBOPLASTIN REAGENT
    Publication number: 20020012958
    Abstract: The present invention relates to a process for increasing the FVII sensitivity of a thromboplastin reagent by means of heat treatment.
    Type: Application
    Filed: May 15, 1998
    Publication date: January 31, 2002
    Applicant: Dade Behring Marburg GmbH
    Inventors: THOMAS WISSEL, HERMANN KEUPER, HUBERT NETTELHOFF, HEINZ-GEORG KANDEL, REINER MUTH, MICHAEL KRAUS