Abstract: Biodegradable polymeric nanoparticles comprising an inner core formed of a photodynamic agent capable of being activated to generate cytotoxic singlet oxygen are prepared. These nanoparticles have anti-cell proliferation activity and are useful in treating both cancerous and non-cancerous conditions including actinic keratosis, psoriasis and acne vulgaris. Preferably, the photodynamic agent is a hypocrellin B derivative while the polymeric nanoparticle comprises polyglycolic acid, polylactic acid or poly(lactide-co-glycolide). Hypocrellin-comprising nanoparticles are demonstrated to be activated by light or hydrogen peroxide.

Abstract: Systems and methods for preventing web services from using sensitive data in customizing web pages for a user. In one embodiment, a protection system is implemented between the user and the web service. The protection system identifies past interactions of the user with the web service, identifies text in the past interactions between the user and the web service, and identifies subjects discussed in the text. The protection system then communicates with the user to determine which of the subjects are sensitive to the user, and deletes a history stored by the web service for the user that relates to the sensitive subjects.

Abstract: A method and computer product are presented for identifying Internet worm propagation based upon changes in packet arrival rates at a network connection. First, unsolicited (i.e., packets that were not requested by the receiver) traffic is separated from solicited traffic at the network connection. The unsolicited traffic arrival patterns are monitored and analyzed for any changes. Once changes in the unsolicited traffic arrival patterns are detected, the changes are mathematically analyzed to detect growth trends. The presence of growth trends that follow certain key characteristics indicate whether the changes are due to worm propagation.

Abstract: The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or sononsensitizers in photodynamic or sonodynamic therapy. The invention also relates to various methods for using these compounds in photodynamic and/or sonodynamic therapy. The compounds also are useful as therapeutic agents for treating various hyperproliferative disorders.

Abstract: Biodegradable polymeric nanoparticles comprising an inner core formed of a photodynamic agent capable of being activated to generate cytotoxic singlet oxygen are prepared. These nanoparticles have anti-cell proliferation activity and are useful in treating both cancerous and non-cancerous conditions including actinic keratosis, psoriasis and acne vulgaris. Preferably, the photodynamic agent is a hypocrellin B derivative while the polymeric nanoparticle comprises polyglycolic acid, polylactic acid or poly(lactide-co-glycolide). Hypocrellin-comprising nanoparticles are demonstrated to be activated by light or hydrogen peroxide.

Abstract: The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or sononsensitizers in photodynamic or sonodynamic therapy. The invention also relates to various methods for using these compounds in photodynamic and/or sonodynamic therapy. The compounds also are useful as therapeutic agents for treating various hyperproliferative disorders.

Abstract: The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or sononsensitizers in photodynamic or sonodynamic therapy. The invention also relates to various methods for using these compounds in photodynamic and/or sonodynamic therapy. The compounds also are useful as therapeutic agents for treating various hyperproliferative disorders.

Abstract: A platform for seamlessly hosts a plurality of disparate types of packet processing applications. One or more applications are loaded onto a service card on the platform. A programmable path structure is included that maps a logical path for processing of the packets through one or more of the plurality of service cards according to characteristics of the packets. Multiple path structures may be programmed into the platform to offer different service paths for different types of packets.

Abstract: Various embodiments provide a method and apparatus of providing wireless access point selection based on performance metric(s) and signal strength. In particular, a client selecting between one of a number of wireless access points bases the selection decision on performance metrics as well as signal strength.

Abstract: Various embodiments relate to a Cloud Data Center, a system comprising the Cloud Data Center, and a related method. The Cloud Data Center may include a logical customer edge router to send packets between addresses in a private enterprise network and addresses in a logical network within a cloud network. The logical network may have resources, known as virtual machines, allocated to the private enterprise network and may share a common IP address space with the private enterprise network. A directory at the Cloud Data Center may correlate the enterprise IP addresses of virtual machines with a cloud IP address and a location IP address within the logical network. The Cloud Data Center may double encapsulate packets with two specified headers, a cloudIP and locIP header, when sending a packet to a destination in the logical network.

Abstract: The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or sononsensitizers in photodynamic or sonodynamic therapy. The invention also relates to various methods for using these compounds in photodynamic and/or sonodynamic therapy. The compounds also are useful as therapeutic agents for treating various hyperproliferative disorders.

Abstract: Various embodiments relate to a Cloud Data Center, a system comprising the Cloud Data Center, and a related method. The Cloud Data Center may include a logical customer edge router to send packets between addresses in a private enterprise network and addresses in a logical network within a cloud network using Layer 2 protocol and MAC addressing. The logical network may have resources, known as virtual machines, allocated to the private enterprise network and may share a common IP address space with the private enterprise network. A directory at the Cloud Data Center may correlate the enterprise IP addresses of virtual machines with a MAC address, cloud IP address, and a location IP address within the logical network. The Cloud Data Center may double encapsulate packets with MAC, cloudIP, and locIP headers, when sending a packet to a destination in the logical network.

Abstract: The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or sononsensitizers in photodynamic or sonodynamic therapy. The invention also relates to various methods for using these compounds in photodynamic and/or sonodynamic therapy. The compounds also are useful as therapeutic agents for treating various hyperproliferative disorders.

Abstract: The present invention relates to a photodynamic therapy method and uses thereof for treating an individual in need thereof, comprising administering a photosensitizer to an individual and activating the photosensitizer with a chemiluminescent light source, and/or a light-emitting diode light source, wherein the light source is in dermal contact with the individual. The present invention also relates to a device for photodynamic therapy comprising a permeable reservoir, for containing a photosensitizer formulation for skin application, the device is adapted to deliver the photosensitizer to the individual. The present invention also relates to a device for photodynamic therapy, comprising a permeable reservoir for containing a photosensitizer formulation for skin application and a light source.

Abstract: A method of balancing user registration lifetimes in a network is disclosed for smoothing the load of the registration server. The method of balancing user registration lifetimes in a network includes providing an initial registration lifetime for a registration request that is calculated using the time of the request and the previous history of registration requests, and in a particular embodiment, using the cumulative distribution function of the history of registration requests. The method of balancing user registration lifetimes in a network is particularly useful for handling spikes in registration traffic, and can accommodate user-specified variable lifetimes, as well dynamic user arrivals and departures. It provides effective load balancing over time for a single server, at the expense of a constant factor additive load per user, which can be amortized to near zero over the long run.

Abstract: Various exemplary embodiments relate to a method of scaling resources of a computing system, the method comprising. The method may include: setting a threshold value for a metric of system performance; determining an ideal resource load for at least one resource based on the threshold value for the metric; distributing a system work load among the computing system resources; and adjusting the number of resources based on the system work load, the ideal resource load, and a current number of resources. Various exemplary embodiments also relate to a computing system for scaling cloud resources. The computing system may include: internal resources; a load balancer; a performance monitor; a communication module; a job dispatching module; and a controller. Various exemplary embodiments also relate to a method of detecting dynamic bottlenecks during resource scaling using a resource performance metric and a method of detecting scaling choke points using historical system performance metric.

Abstract: In a method and architecture for multimedia conferencing, each upstream and downstream traffic flow is processed in a custom manner. The custom processing is capable of handling diverse capabilities of end-user devices, diverse access networks over which each conference participant joins the multimedia conference, and/or customizing personalized conference experience for each conference participant.

Abstract: Various exemplary embodiments relate to a method and related network node including one or more of the following: receiving, at the node, a network state update message; updating a first portion of a first set of routing information based on the network state update message; after updating the first portion of the first set of routing information, beginning an update of a second set of routing information; and after beginning the update of the second set of routing information, updating a second portion of the first set. In various alternative embodiments, the step of updating the first portion includes one or more of the following: determining at least one other node within the network for which routing information should be used to update the second set of routing information; and updating routing information associated with the at least one other node in the first set of routing information.

Abstract: A platform for seamlessly hosts a plurality of disparate types of packet processing applications. One or more applications are loaded onto a service card on the platform. A programmable path structure is included that maps a logical path for processing of the packets through one or more of the plurality of service cards according to characteristics of the packets. Multiple path structures may be programmed into the platform to offer different service paths for different types of packets.

Abstract: A platform for seamlessly hosts a plurality of disparate types of packet processing applications. One or more applications are loaded onto a service card on the platform. A programmable path structure is included that maps a logical path for processing of the packets through one or more of the plurality of service cards according to characteristics of the packets. Multiple path structures may be programmed into the platform to offer different service paths for different types of packets.