Abstract: The present invention relates, in part, to targeted chimeric proteins with beneficial therapeutic effects, including, for example, effects mediated by mutant forms of soluble agents that are part of the chimeric proteins. Pharmaceutical compositions comprising the chimeric proteins are also provided. The present invention finds use in the treatment of various disease and disorders.

Abstract: The present invention relates, in part, to targeted chimeric proteins with beneficial therapeutic effects, including, for example, effects mediated by mutant forms of soluble agents that are part of the chimeric proteins. Pharmaceutical compositions comprising the chimeric proteins are also provided. The present invention finds use in the treatment of various disease and disorders.

Abstract: The present invention relates, in part, to targeted chimeric proteins with beneficial therapeutic effects, including, for example, effects mediated by mutant forms of soluble agents that are part of the chimeric proteins. Pharmaceutical compositions comprising the chimeric proteins are also provided. The present invention finds use in the treatment of various disease and disorders.

Abstract: An elevator cage is movable in an elevator shaft, wherein a ventilating device is fastened to a cage outer surface, wherein this ventilating device forms at least one ventilation channel, wherein the at least one ventilation channel has at least one primary ventilation opening enabling an air exchange between the ventilation channel and the elevator shaft, wherein at least one of the cage outer surfaces has at least one secondary ventilation opening enabling an air exchange between a cage interior space and the at least one ventilation channel, with at least one element of insulating material, and wherein the at least one element substantially determines a path of the at least one ventilation channel.

Abstract: An elevator cage floor has a composite-structure or sandwich mode of construction, including at least one base plate, at least one top plate and at least one composite-structure core disposed therebetween and having at least two chambers, wherein the composite-structure core is connected with the base plate and the top plate. At least one of the at least two chambers of the composite-structure core is at least partly filled with a defined amount of a filler.

Abstract: A floor for an elevator cage has a base plate, a top plate and a support structure arranged therebetween. The support structure comprises a grating arrangement including a plurality of intersecting profile members standing on edge. For local reinforcement, the support structure additionally includes a second grating arrangement superimposed on the first arrangement.

Abstract: An elevator installation includes an elevator cage with a support construction carrying the elevator cage, wherein the support construction has two beams. Mounted on each beam is a positioning arrangement on which, for example, a sensor is positioned, which is part of a load measuring device, wherein the positioning arrangements have material structures or sensor carriers. The sensors detect a change in spacing of the material structures or of the sensor carriers from one another, wherein this change in spacing is caused by a change in loading of the elevator cage. Signals of the sensors are processed in an evaluating unit and a signal representing the loading is used in an elevator control.

Abstract: Specific binding members, particularly antibodies and fragments thereof, which bind to Fibroblast Activation Protein (FAP) are provided, particularly recognizing both human and mouse FAP. These antibodies are useful in the diagnosis and treatment of conditions associated with activated stroma, including wound healing, epithelial cancers, osteoarthritis, rheumatoid arthritis, cirrhosis and pulmonary fibrosis. The anti-FAP antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies ESC1 1 and ESC 14 whose sequences are provided herein.

Abstract: A floor for an elevator cage has a base plate, a top plate and a support structure arranged therebetween. The support structure comprises a grating arrangement including a plurality of intersecting profile members standing on edge. For local reinforcement, the support structure additionally includes a second grating arrangement superimposed on the first arrangement.

Abstract: Specific binding members, particularly antibodies and fragments thereof, which bind to Fibroblast Activation Protein (FAP) are provided, particularly recognizing both human and mouse FAP. These antibodies are useful in the diagnosis and treatment of conditions associated with activated stroma, including wound healing, epithelial cancers, osteoarthritis, rheumatoid arthritis, cirrhosis and pulmonary fibrosis. The anti-FAP antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies ESC1 1 and ESC 14 whose sequences are provided herein.

Abstract: An elevator cage floor has a composite-structure or sandwich mode of construction, including at least one base plate, at least one top plate and at least one composite-structure core disposed therebetween and having at least two chambers, wherein the composite-structure core is connected with the base plate and the top plate. At least one of the at least two chambers of the composite-structure core is at least partly filled with a defined amount of a filler.

Abstract: An elevator cage is movable in an elevator shaft, wherein a ventilating device is fastened to a cage outer surface, wherein this ventilating device forms at least one ventilation channel, wherein the at least one ventilation channel has at least one primary ventilation opening enabling an air exchange between the ventilation channel and the elevator shaft, wherein at least one of the cage outer surfaces has at least one secondary ventilation opening enabling an air exchange between a cage interior space and the at least one ventilation channel, with at least one element of insulating material, and wherein the at least one element substantially determines a path of the at least one ventilation channel.

Abstract: An elevator installation includes an elevator cage with a support construction carrying the elevator cage, wherein the support construction has two beams. Mounted on each beam is a positioning arrangement on which, for example, a sensor is positioned, which is part of a load measuring device, wherein the positioning arrangements have material structures or sensor carriers. The sensors detect a change in spacing of the material structures or of the sensor carriers from one another, wherein this change in spacing is caused by a change in loading of the elevator cage. Signals of the sensors are processed in an evaluating unit and a signal representing the loading is used in an elevator control.