Patents by Inventor Thomas WYCHE

Thomas WYCHE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Forazolines, compositions thereof and uses thereof
    Patent number: 11135203
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: October 5, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Timothy Bugni, Thomas Wyche, David Andes, Douglas Braun
  • Compositions and methods for modulating protease activity
    Patent number: 11124498
    Abstract: Disclosed herein, inter alia, are compositions for modulating protease activity and treating cancer.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: September 21, 2021
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Michael A. Fischbach, Chun-Jun Guo, Christopher A. Voigt, Fang-Yuan Chang, Jon Clardy, Thomas Wyche
  • COMPOSITIONS AND METHODS FOR MODULATING PROTEASE ACTIVITY
    Publication number: 20200048227
    Abstract: Disclosed herein, inter alia, are compositions for modulating protease activity and treating cancer.
    Type: Application
    Filed: November 15, 2017
    Publication date: February 13, 2020
    Inventors: Michael A. Fischbach, Chun-Jun Guo, Christopher A. Voigt, Fang-Yuan Chang, Jon Clardy, Thomas Wyche
  • FORAZOLINES, COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20180243269
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Application
    Filed: May 1, 2018
    Publication date: August 30, 2018
    Inventors: Timothy BUGNI, Thomas WYCHE, David ANDES, Douglas BRAUN
  • FORAZOLINES, COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20160243089
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Application
    Filed: May 4, 2016
    Publication date: August 25, 2016
    Inventors: Timothy BUGNI, Thomas WYCHE, David ANDES, Douglas BRAUN
  • Forazolines, compositions thereof and uses thereof
    Patent number: 9346828
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: May 24, 2016
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Timothy Bugni, Thomas Wyche, David Andes, Douglas Braun
  • FORAZOLINES, COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20140364385
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Application
    Filed: June 9, 2014
    Publication date: December 11, 2014
    Inventors: Timothy BUGNI, Thomas WYCHE, David ANDES, Douglas BRAUN
  • Method and system for producing an improved hiking trail map
    Patent number: 5857066
    Abstract: A method and system of producing a 3D perspective representation of a hiking trail or the like in two dimensions. Manually-obtained first data indicative of a heading and distance of each approximately linear segment of the course of travel are correlated with second data indicative of a topography of an underlying geographical region. A representation of the course of travel as viewed from perspective may then be selectively produced utilizing the correlated data. Linear segments of the course of travel are shown in this view situated at a relative angle with respect to adjacent linear segments, the angle representative of a direction and slope thereof. As a result, changes in elevation of the course of travel are continuously shown on the perspective two-dimensional representation to facilitate visual appreciation of the difficulty thereof by the traveller.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: January 5, 1999
    Assignee: Naturaland Trust
    Inventors: C. Thomas Wyche, James B. Conlon
  • Adjustable rungs for ladder
    Patent number: 5060757
    Abstract: Adjustable cross pieces or rungs for aiding in forming a ladder using a tree cut at predetermined lengths and trimmed of branches. The cross members include two end members and a centrally located channel member which receives an elongated main body portion of the end members and which can be stabilized at the top and bottom rungs for securing the trees together and forming foot rests or rungs for the ladder.
    Type: Grant
    Filed: July 11, 1990
    Date of Patent: October 29, 1991
    Assignee: Naturaland Trust
    Inventor: C. Thomas Wyche