Patents by Inventor Thomas WYCHE

Thomas WYCHE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Forazolines, compositions thereof and uses thereof
    Patent number: 11135203
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: October 5, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Timothy Bugni, Thomas Wyche, David Andes, Douglas Braun
  • Compositions and methods for modulating protease activity
    Patent number: 11124498
    Abstract: Disclosed herein, inter alia, are compositions for modulating protease activity and treating cancer.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: September 21, 2021
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Michael A. Fischbach, Chun-Jun Guo, Christopher A. Voigt, Fang-Yuan Chang, Jon Clardy, Thomas Wyche
  • COMPOSITIONS AND METHODS FOR MODULATING PROTEASE ACTIVITY
    Publication number: 20200048227
    Abstract: Disclosed herein, inter alia, are compositions for modulating protease activity and treating cancer.
    Type: Application
    Filed: November 15, 2017
    Publication date: February 13, 2020
    Inventors: Michael A. Fischbach, Chun-Jun Guo, Christopher A. Voigt, Fang-Yuan Chang, Jon Clardy, Thomas Wyche
  • FORAZOLINES, COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20180243269
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Application
    Filed: May 1, 2018
    Publication date: August 30, 2018
    Inventors: Timothy BUGNI, Thomas WYCHE, David ANDES, Douglas BRAUN
  • FORAZOLINES, COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20160243089
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Application
    Filed: May 4, 2016
    Publication date: August 25, 2016
    Inventors: Timothy BUGNI, Thomas WYCHE, David ANDES, Douglas BRAUN
  • Forazolines, compositions thereof and uses thereof
    Patent number: 9346828
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: May 24, 2016
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Timothy Bugni, Thomas Wyche, David Andes, Douglas Braun
  • FORAZOLINES, COMPOSITIONS THEREOF AND USES THEREOF
    Publication number: 20140364385
    Abstract: An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
    Type: Application
    Filed: June 9, 2014
    Publication date: December 11, 2014
    Inventors: Timothy BUGNI, Thomas WYCHE, David ANDES, Douglas BRAUN