Abstract: Disclosed is a stopper for use with containers to provide needleless access to the container with a cannula having a blunt penetrating tip. Also disclosed is a system comprising the stopper, container and cannula. The stopper includes a disc having an upper face and a lower face, and a plug extending from the disc into the container. Also included is a diaphragm, defined by a target region in the upper face and a cross channel in the disc for controlling the force needed to penetrate the stopper with the cannula. The plug includes a first inward surface for guiding the cannula and a second inward surface for engaging the cannula to minimize wetting of the outside of the cannula. In a preferred embodiment, the first surface extends down from the cross channel on the lower side of the disc, radially outwardly to a maximum diameter and the second inwardly facing surface extends down from the first surface radially inwardly to a minimum diameter to form the cannula seal.

Abstract: A closure for a tubular administration port is formed by inner and outer members having upper ends joined together in sealing relationship. The inner member has a sealed bottom end and is configured to fit within the administration port. The outer member is configured to engage about an exterior of the tubular port. The inner member includes radially outwardly extending ribs that engage against the interior of the administration port in an interference fit relationship.