Abstract: The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

Abstract: The invention relates to compounds of the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

Abstract: The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

Abstract: Described herein are bifunctional degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment of conditions, diseases, and disorders mediated by various target proteins.

Abstract: An energy store includes a storage module having a fan. The fan is arranged as a radial fan, and channels extend through the storage module, e.g., axially, open into a spatial region which is delimited by a cover part of the energy store connected to the storage module and the storage module. The cover part has a recess extending through the cover part, e.g., axially, which is covered by the fan, e.g., by the suction region of the fan, e.g., on the side of the cover part facing away from the storage module, and the energy store has a deflection hood, e.g., for deflecting the conveyed air flow in the axial direction, on the side of the cover part facing away from the storage module.

Abstract: The disclosure provides BRD9 bifunctional compounds of Formula (A), (BF-I), (BF-II), (BF-III), (BF-IIIa), (BF-IIIb), (BF-IV), (BF-IVa), (BF-IVb), (BF-I?), (BF-II?), (BF-III?), (BF-IV?), or (BF-V?), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, to their preparation, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases and disorders mediated by a bromodomain-containing protein, such as bromodomain-containing protein 9 (BRD9).

Abstract: An energy store includes a housing and bridge plug. In relation to the housing, the bridge plug is receivable by the housing in two orientations different from each other, e.g., in the same opening or configuration of openings.

Abstract: A fan arrangement includes a fan and toothed ring, and a converter motor includes a fan arrangement. The fan includes a base body on which fan blades are premolded, and the fan includes an annular region, which is premolded on the side of the fan blades facing away from the base body. The toothed ring is situated within the annular region, and thus, in particular, is set apart from the base body, and thus, in particular, is set apart from the base body via the fan blades.

Abstract: In a system and method for operating a system, which includes a first inverter which feeds a first electric motor, and a second inverter which feeds a second electric motor, the DC-voltage side connection of the first inverter is connected to the DC-voltage side connection of a rectifier which is supplied from an electrical AC-voltage supply network, the DC-voltage side connection of the second inverter is connected to the DC-voltage side connection of the rectifier, in particular, the two DC-voltage side connections of the inverters are switched in parallel, and a controller is provided, in particular in the first inverter, which controls the current accepted and acquired by the first inverter at its DC-voltage side terminal toward a setpoint value in that the torque of the first electric motor fed by the first inverter is the controlled variable.

Abstract: In a system and method for operating a system, which includes a first inverter which feeds a first electric motor, and a second inverter which feeds a second electric motor, the DC-voltage side connection of the first inverter is connected to the DC-voltage side connection of a rectifier which is supplied from an electrical AC-voltage supply network, the DC-voltage side connection of the second inverter is connected to the DC-voltage side connection of the rectifier, in particular, the two DC-voltage side connections of the inverters are switched in parallel, and a controller is provided, in particular in the first inverter, which controls the current accepted and acquired by the first inverter at its DC-voltage side terminal toward a setpoint value in that the torque of the first electric motor fed by the first inverter is the controlled variable.

Abstract: The invention relates to compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

Abstract: The invention relates to compounds of the formula (I) (I) or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

Abstract: The invention relates to a two-component polyurethane adhesive containing i) a polyol component including a mixture of three different polyols to ensure crosslinking for a mechanically stable adhesive bonding, and also to achieve hydrophobia to ensure that the crosslinked adhesive layer is impervious to moisture, and glass fibers, and ii) an isocyanate component containing polyisocyanates in an NCO/OH ratio of 0.9:1 to 1.5:1. The polyol component further includes a metal catalyst. The two-component adhesive has a high adhesive strength, a high glass temperature, a low curing time and a sufficiently long processing time, which can adhesively bond also substrates having uneven surfaces. The invention further relates to an article comprising the two-component polyurethane adhesive.

Abstract: A fan arrangement includes a fan and toothed ring, and a converter motor includes a fan arrangement. The fan includes a base body on which fan blades are premolded, and the fan includes an annular region, which is premolded on the side of the fan blades facing away from the base body. The toothed ring is situated within the annular region, and thus, in particular, is set apart from the base body, and thus, in particular, is set apart from the base body via the fan blades.

Abstract: The present invention describes new pyrazolo-pyrimidine derivatives according to Formula (I) which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

Abstract: In a system and method for operating a system, which includes a first inverter which feeds a first electric motor, and a second inverter which feeds a second electric motor, the DC-voltage side connection of the first inverter is connected to the DC-voltage side connection of a rectifier which is supplied from an electrical AC-voltage supply network, the DC-voltage side connection of the second inverter is connected to the DC-voltage side connection of the rectifier, in particular, the two DC-voltage side connections of the inverters are switched in parallel, and a controller is provided, in particular in the first inverter, which controls the current accepted and acquired by the first inverter at its DC-voltage side terminal toward a setpoint value in that the torque of the first electric motor fed by the first inverter is the controlled variable.

Abstract: The invention relates to a two-component adhesive on the basis of polyurethanes, having a high adhesive strength, a high glass temperature, a low curing time and a sufficiently long processing time, which can adhesively bond also substrates having uneven surfaces. The invention further relates to the use of the two-component adhesive for the adhesive bonding of molded fiber parts, such as, for example, wing half-shells of rotor blades for wind power plants.

Abstract: The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

Abstract: The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

Abstract: The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.