Abstract: The invention concerns a hydraulic valve arrangement with a supply connection arrangement, which has a high-pressure connection (P) and a low-pressure connection (T), a working connection arrangement, which has two working connections (A, B), which can be connected with a consumer, a directional valve and a compensation valve arranged between the directional valve and the supply connection arrangement, the pressure outlet of the compensation valve being connected with a pressure inlet of the directional valve. It is endeavoured to avoid dangerous situations, which occur because of uncontrolled pressures. For this purpose, it is ensured that the compensation valve has a relief outlet, which can be connected with the pressure outlet.

Abstract: A hydraulic valve system (1) with a supply connection arrangement, has a high-pressure connection (P) and a low-pressure connection (T), and a working connection arrangement, having two working connections (A, B), which can be connected with a motor, and a directional valve (4) and a compensation valve (9). A compensation valve (9) is arranged after the directional valve (4) in the flow direction and a pressure relief device (43) is arranged between the directional valve (4) and the low-pressure connection (T).

Abstract: A hydraulic valve system (1) has a supply connection arrangement having a high-pressure connection (P) and a low-pressure connection (T), a working connection arrangement, having two working connections (A, B) connectable with a motor (2), with a directional valve (4), which is arranged between the supply connection arrangement (P, T) and the working connection arrangement (A, B), and with a compensation valve (8), which is acted upon in a first operation direction by a spring (22) and a pressure in a pressure chamber (23), which is connected with a load-sensing line (LS), and in a second operation direction, which is opposite to the first operation direction, by a pressure at the directional valve (4).

Abstract: A hydraulic valve system (1) has a supply connection arrangement, having a high-pressure connection (P) and a low-pressure connection (T), a working connection arrangement, having two working connections (A, B), which can be connected with a hydraulic motor (2), and a directional valve (4) between the supply connection arrangement (P, T) and the working connection arrangement (A, B), which is connected with the working connection arrangement (A, B) via working lines (17, 18), in which are arranged check valves (21, 22), which can be opened by means of pressure.

Abstract: The invention concerns a pressure reduction valve (1) with a housing (2a, 2b), a valve element (6) being displaceable in the housing and acted upon in one direction by a pressure in a low-pressure chamber connected with an outlet (11) and in the opposite direction by the force of a spring (16), which is arranged in a spring chamber (17) in the housing (2a). It is endeavoured to improve the dynamic behaviour of the pressure reduction valve. For this purpose, a pilot flow path (7, 23, 21) connects the low-pressure chamber (5) and the spring chamber (17) with each other.

Abstract: A readily-soluble freeze-dried solid preparation of hGH with a minimal content of degradation products in terms of deamidation, dimers, polymers, and sulphoxide forms, obtainable by a method comprising a single lyophilization of an aqueous slurry of an amorphous hGH isoprecipitate, the slurry having a pH of from about 4.7 to 5.0 and being essentially free of buffer components other than acetate.

Abstract: A hydraulic valve arrangement includes a control valve (3), which, in a first operating position (5), connects a motor connection (21) with a pump connection, in a second operating position (6), connects a motor connection with a tank connection, and, in a locking position (4), disconnects the motor connection (21) from the pump and tank connection. A locking valve (19) is coupled between the control valve (3) and the motor connection (21), dividing the motor line (22) into a first section (23) allocated to the control valve (3) and a second section (24) allocated to the motor connection (21). For the locking valve (19), a pressure release valve (20) in the shape of a seated valve is provided that is fixed to the housing thereby improving control accuracy.

Abstract: The invention concerns a hydraulic valve arrangement with locking function. It has a control valve (9), which in two operating positions (11, 12) connects one motor connection (A) with a pump connection and a second motor connection (B) with a tank connection and vice versa, and in a locking position (10) separates both motor connections (A, B) from pump and tank connection. Further, there are two lock valves (16, 17), each connected between the control valve (9) and one of the motor connections (A, B).

Abstract: The invention concerns a hydraulic valve arrangement with a control valve (3), which, in a first operating position (5), connects a motor connection (21) with a pump connection, in a second operating position (6), connects a motor connection with a tank connection, and, in a locking position (4), disconnects the motor connection (21) from the pump and tank connection. A locking valve (19) is coupled between the control valve (3) and the motor connection (21), dividing the motor line (22) into a first section (23) allocated to the control valve (3) and a second section (24) allocated to the motor connection (21). For the locking valve (19), a pressure release valve (20) in the shape of a seated valve is provided. The operating element (32) of said pressure release valve (20) is loaded in the closing direction by the pressure in the first section (23) and a spring (36) and in the opening direction by a constant control pressure (V) acting in dependence of the position of the control valve (3).

Abstract: A desired protein having the formula:

Abstract: A hydraulic valve arrangement with locking and floating function, with a control valve (9), which, for two operating positions (11, 12) connects one motor connection (A) with a pump connection and a second motor connection (B) with a tank connection and vice versa, in a floating position (13) connects both motor connections (A, B) with the tank connection and in a locking position (10) separates both motor connections (A, B) from the pump and tank connections. Further, there are two closing valves (16, 17), each being connected between the control valve (9) and a motor connection (A, B) and each having a piston loaded by a spring and limiting a spring chamber, the spring chambers being pressure releasable. Characteristic of this valve arrangement is that lifting valves (18, 19) are provided for the pressure release, which valves are operated by a control pressure depending on the position of the control valve (9). This improves the operating reliability.

Abstract: An add-in device for a hydraulic control arrangement provides a function unit (24) to be arranged between successive modules, which function unit takes the connection between the pump channels of the preceding and the subsequent module by way of at least one function slide valve (117, 217) which is arranged to be displaced into several positions. In its positions this function slide valve initiates different functions, by which fluid under pressure is arranged to be admitted to the subsequent control module in at least two different amounts and/or in at least two different levels of pressure. In this manner operation of the subsequent control modules can be better matched to the particular operating conditions that obtain.

Abstract: A pharmaceutical formulation comprising a growth hormone and Leu-His-Leu as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved formulation at ambient temperature.

Abstract: A desired protein having the formula:A-B-C-Pwhereina) A is Lys or Arg, and B and C are arbitrary amino acids, orb) A is an arbitrary amino acid different from Pro, Lys and Arg, and B and/or C is Pro,is produced from a biosynthetically formed amino acid extended protein having the formula:X-A-B-C-Pwherein A, B, C and P are as defined above, and X is an amino acid sequence with an even number of amino acids, of which the first one, seen from the N-terminal end, is different from Lys and Arg, all other uneven amino acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Thus, e.g. hGH without content of Met-hGH may be produced by the process.

Abstract: A desired protein having the formula:A--B--C--Pwhereina) A is Lys or Arg, and B and C are arbitrary amino acids, orb) A is an arbitrary amino acid different from Pro, Lys and Arg, and B and/or C is Pro,is produced from a biosynthetically formed amino acid extended protein having the formula:X--A--B--C--Pwherein A, B, C and P are as defined above, and X is an amino acid sequence with an even number of amino acids, of which the first one, seen from the N-terminal end, is different from Lys and Arg, all other uneven amino acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Thus, e.g. hGH without content of Met-hGH may be produced by the process.

Abstract: A desired protein having the formula:A-B-C-P,wherein (a) A is Lys or Arg, and B and C are arbitrary amino acids, or (b) A is an arbitrary amino acid different from Pro, Lys, and Arg, and B and/or C is Pro is produced from a biosynthetically formed amino-terminally extended protein having the formula:X-A-B-C-P,wherein A, B, C are defined above, and X is an amino acid sequence with an even number of amino acids, of which the first amino acid, seen from the N-terminal end, is different from Lys and Arg, all other am/no acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Specifically, P is human growth hormone (hGH). Thus, compositions of hGH may be produced without the presence of Met-hGH.

Abstract: A desired protein having the formula:A-B-C-Pwhereina) A is Lys or Arg, and B and C are arbitrary amino acids, orb) A is an arbitrary amino acid different from Pro, Lys and Arg, and B and/or C is Pro,is produced from a biosynthetically formed amino acid extended protein having the formula:X-A-B-C-Pwherein A, B, C and P are as defined above, and X is an amino acid sequence with an even number of amino acids, of which the first one, seen from the N-terminal end, is different from Lys and Arg, all other uneven amino acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Thus, e.g. hGH without content of Met-hGH may be produced by the process.

Abstract: A process for producing ripe human growth hormone is described which comprises introducing into bacteria a recombinant DNA vector comprising a DNA sequence encoding an amino-terminal extended human growth hormone which amino-terminal extension has a negatively charged amino acid sequence and has an even number of amino acids, growing the bacteria such that the amino-terminal extended human growth is expressed, separating the amino-terminal extended human grown hormone from contaminants, cleaving the amino-terminal extension with dipeptidyl aminopeptidase I to obtain ripe human growth hormone and isolating the ripe human growth hormone produced.

Abstract: A pharmaceutical formulation comprising a growth hormone and Lys-Gly-Asp-Ser (SEQ ID No: 1) as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved formulation at ambient temperature.

Abstract: A pressure control valve of the type having pump, tank and load-sensing connections used in conjunction with one or more proportional type valves. In this type of system a load-sensing signal is tapped off from the output side of the proportional valves and conveyed to the load-sensing connection of the pressure control valve. A pressure control valve of the type herein has load-sensing and pressure chambers at opposite ends thereof with a slide valve therebetween which is spring biased towards the pressure chamber and controls the internal flow from the pump connection to the tank connection. The slide valve has an auxiliary change-over type valve which selectively connects the pressure chamber to the pump and load-sensing connections in response to a pressure differential between the pump and load-sensing connections to achieve a pressure balance between the load-sensing chamber and the pressure chamber.