Patents by Inventor Thorsten Blume

Thorsten Blume has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzimidazole derivatives as EP4 antagonists
    Patent number: 9708311
    Abstract: The present invention relates to novel benzimidazole derivatives of the general formula processes for their preparation and their use for the production of pharmaceutical compositions for the treatment of diseases and indications that are connected with the receptor EP4.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: July 18, 2017
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Olaf Peters, Nico Bräuer, Thorsten Blume, Antonius Ter Laak, Ludwig Zorn, Jens Nagel, Stefan Kaulfuss, Gernot Langer, Joachim Kuhnke
  • NOVEL BENZIMIDAZOLE DERIVATIVES AS EP4 ANTAGONISTS
    Publication number: 20160214977
    Abstract: The present invention relates to novel benzimidazole derivatives of the general formula (I), processes for their preparation and their use for the production of pharmaceutical compositions for the treatment of diseases and indications that are connected with the receptor EP4.
    Type: Application
    Filed: December 3, 2013
    Publication date: July 28, 2016
    Inventors: Olaf PETERS, Nico BRÄUER, Thorsten BLUME, Antonius TER LAAK, Ludwig ZORN, Jens NAGEL, Stefan KAULFUSS, Gernot LANGER, Joachim KUHNKE
  • ESTRATRIENE DERIVATIVES COMPRISING HETEROCYCLIC BIOISOSTERES FOR THE PHENOLIC A-RING
    Publication number: 20110190246
    Abstract: The present invention is directed to novel pyrazolo-estrien and triazolo-estrien-derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by an estrogen receptor such as hot flashes, vaginal dryness, osteopenia, osteoporosis, hyperlipidemia, loss of cognitive function, degenerative brain diseases, cardiovascular diseases, cerebrovascular diseases, hormone sensitive cancers and hyperplasia (in tissues including breast, endometrium, and cervix in women and prostate in men), endometriosis, uterine fibroids, osteoarthritis; and as contraceptive agents either alone or in combination with a progestogen or progestogen antagonist. The compounds of the invention are selective estrogen receptor modulators.
    Type: Application
    Filed: July 14, 2009
    Publication date: August 4, 2011
    Applicant: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Thorsten Blume, Dieter Heldmann, Norbert Schmees, Christiane Otto, Tim Wintermantel, Joachim Kuhnke
  • 1-phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 7683081
    Abstract: New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: March 23, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Thorsten Blume, Bernd Elger, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Herbert Schneider
  • Thiomorpholino steroid compounds, the use thereof for the preparation of meiosis-regulating medicaments and method for the preparation thereof
    Publication number: 20070078262
    Abstract: The present invention relates to thiomorpholino steroid compounds of general formula I, which may advantageously be employed to stimulate meiosis in human oocytes, the steroid being specifically characterized by a thiomorpholino moiety bonded to C17 of the steroid skeleton via an alkylen spacer.
    Type: Application
    Filed: July 13, 2004
    Publication date: April 5, 2007
    Applicant: SCHERING AKTIENGESELLSCHAFT
    Inventors: Thorsten Blume, Bernhard Lindenthal, Katja Prelle, Michaele Peters-Kottig
  • 1-aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 7196202
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: March 27, 2007
    Assignee: Schering AG
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Monning, Herbert Schneider
  • Microglia inhibitors for interrupting interleukin 12 and IFNgamma-mediated immune reactions
    Publication number: 20060211690
    Abstract: The invention describes the use of microglia inhibitors for the production of pharmaceutical agents that inhibit immune reactions that are mediated by monocytes, macrophages and T cells, and their use for treating T-cell-mediated immunological diseases and non-T-cell-mediated inflammation reactions.
    Type: Application
    Filed: February 9, 2006
    Publication date: September 21, 2006
    Applicant: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolf-Dietrich Doecke, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Bernd Elger, Herbert Schneider
  • Aromatic sulfonamides as peroxynitrite-rearrangement catalysts
    Publication number: 20050288324
    Abstract: The invention relates to the use of aromatics sulfonamides of the general formula I as peroxynitrite rearrangement catalysts, to the preparation thereof and to the use thereof as medicament for the treatment of various disorders.
    Type: Application
    Filed: August 4, 2005
    Publication date: December 29, 2005
    Inventors: Thorsten Blume, Roland Neuhaus, Detlev Suelzle, Iris Pribilla, Gisbert Depke, Joseph Beckman
  • 1-Phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Publication number: 20050267160
    Abstract: New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
    Type: Application
    Filed: August 4, 2005
    Publication date: December 1, 2005
    Applicant: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Bernd Elger, Herbert Schneider
  • 1-phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 6962932
    Abstract: New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: November 8, 2005
    Assignee: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Bernd Elger, Herbert Schneider
  • Aromatic sulfonamides as peroxynitrite-rearrangement catalysts
    Patent number: 6946466
    Abstract: The invention relates to the use of aromatics sulfonamides of the general formula I as peroxynitrite rearrangement catalysts, to the preparation thereof and to the use thereof as medicament for the treatment of various disorders.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: September 20, 2005
    Assignee: Schering AG
    Inventors: Thorsten Blume, Roland Neuhaus, Detlev Suelzle, Iris Pribilla, Gisbert Depke, Joseph S. Beckman
  • Steroid compounds, use of these compounds for the preparation of meiosis-regulating medicaments and method for the preparation of these compounds
    Patent number: 6916921
    Abstract: The present invention relates to steroid compounds of general formula X, which may advantageously be employed to stimulate meiosis in human oocytes, the steroid being specifically characterized by amino nitrogen bonded to C17 of the steroid skeleton via a spacer A.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: July 12, 2005
    Assignees: Schering AG, Novo Nordisk D/S
    Inventors: Thorsten Blume, Peter Esperling, Christa Hegele-Hartung
  • 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Publication number: 20050143439
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds.
    Type: Application
    Filed: February 24, 2005
    Publication date: June 30, 2005
    Applicant: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Monning, Herbert Schneider
  • 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 6903126
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: June 7, 2005
    Assignee: Schering AG
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Monning, Herbert Schneider
  • Meiosis regulating compounds
    Publication number: 20050101573
    Abstract: Certain novel sterol derivatives can be used for regulating the meiosis in oocytes and in male germ cells.
    Type: Application
    Filed: December 16, 2004
    Publication date: May 12, 2005
    Applicants: Novo Nordisk A/S, Schering AG
    Inventors: Peter Faarup, Frederick Gronvald, Thorsten Blume, Anthony Murray, Jens Breinholt
  • Meiosis regulating compounds
    Patent number: 6884796
    Abstract: Certain novel sterol derivatives can be used for regulating the meiosis in oocytes and in male germ cells.
    Type: Grant
    Filed: June 4, 2002
    Date of Patent: April 26, 2005
    Assignees: NovoNordisk A/S, Schering AG
    Inventors: Peter Faarup, Frederick Christian Grønvald, Thorsten Blume, Anthony Murray, Jens Breinholt
  • 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 6855714
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B and Y have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treating and for preventing diseases that are associated with microglia activation, as well as pharmaceutical preparations that contain these compounds.
    Type: Grant
    Filed: July 5, 2002
    Date of Patent: February 15, 2005
    Assignee: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Herbert Schneider, Bernd Elger
  • Aromatic sulfonamides as peroxynitrite-rearrangement catalysts
    Publication number: 20040204452
    Abstract: The invention relates to the use of aromatics sulfonamides of the general formula I as peroxynitrite rearrangement catalysts, to the preparation thereof and to the use thereof as medicament for the treatment of various disorders.
    Type: Application
    Filed: April 10, 2003
    Publication date: October 14, 2004
    Applicant: Schering AG
    Inventors: Thorsten Blume, Roland Neuhaus, Detlev Suelzle, Iris Pribilla, Gisbert Depke, Joseph S. Beckman
  • Process for the production of 4,4-dimethyl-5&agr;-cholesta-8,14,24-trien-3&bgr;-01 and intermediate products in process (I)
    Patent number: 6683197
    Abstract: The subject of this invention is a new process with variant embodiments for the production of compound 1.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: January 27, 2004
    Assignee: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Peter Esperling, Joachim Kuhnke
  • Meiosis regulating compounds
    Patent number: RE39678
    Abstract: Certain novel sterol derivatives can be used for regulating the meiosis in oocytes and in male germ cells.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: June 5, 2007
    Assignees: Novo Nordisk A/S, Schering Aktiengesellschaft
    Inventors: Peter Faarup, Frederik Christian Grønvald, Thorsten Blume, Anthony Murray, Jens Breinholt