Patents by Inventor Thorsten Eggert
Thorsten Eggert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11739310Abstract: An amino acid sequence may have at least 70% sequence identity to the amino acid sequence identified in SEQ ID No. 1 over its entire length, and (a) an amino acid substitution on the position corresponding to the position 271, and (b1) at least one other amino acid substitution for at least one of the positions corresponding to the positions 18, 61, 92, 99, 137, 149, 156, 159, 162, 166, 172, 192, 199, 217, 265, or combinations thereof; and/or (b2) an amino acid substitution on the position corresponding to the position 9, and another amino acid substitution for at least one position corresponding to the positions 29, 48, 101, 130, 31, 133, 144, 217, 224, 252, or combinations thereof. Such proteases are useful for in washing or cleaning agents.Type: GrantFiled: September 5, 2018Date of Patent: August 29, 2023Assignee: Henkel AG & Co. KGaAInventors: Nina Mussmann, Susanne Wieland, Daniela Herbst, Inken Prueser, Christian Degering, Daria Strauss, Thorsten Eggert, Christian Leggewie, Layla Fernandez, Sabine Griemert
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Patent number: 11535817Abstract: The present disclosure relates to proteases having an amino acid sequence with at least 70% sequence identity to the amino acid sequence given in SEQ ID No. 1, across its whole length, and comprising an amino acid substitution on at least one of the positions P9, Q10, Q62, L82, P86, N130, T141, N187, S236 or T253, relating in each case to the numbering according to SEQ ID No. 1. The present disclosure also relates to the production and use thereof. Said type of proteases have a very good cleaning performance.Type: GrantFiled: March 7, 2017Date of Patent: December 27, 2022Assignee: HENKEL AG & CO. KGAAInventors: Nina Mussmann, Timothy O'Connell, Daniela Herbst, Inken Prueser, Christian Degering, Sabine Griemert, Thorsten Eggert, Christian Leggewie
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Patent number: 11421213Abstract: An amino acid sequence may have at least 70% sequence identity to the amino acid sequence identified in SEQ ID No. 1 over its entire length, and (a) amino acid substitutions at the positions corresponding to the positions 9 and 271 in each case based on the numbering according to SEQ ID No. 1, and (b) an amino acid substitution on at least one of the positions corresponding to the positions 29, 48, 101, 30, 131, 133, 144, 224 or 252, in each case based on the numbering according to SEQ ID No. 1. Such proteases are particularly suitable for having an improved cleaning performance.Type: GrantFiled: September 5, 2018Date of Patent: August 23, 2022Assignee: HENKEL AG & CO. KGAAInventors: Layla Fernandez, Sabine Griemert, Nina Mussmann, Susanne Wieland, Daniela Herbst, Inken Prueser, Christian Degering, Daria Strauss, Thorsten Eggert, Christian Leggewie
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Patent number: 11046961Abstract: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a) a promoter sequence and b) a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified in SEQ ID NO: 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.Type: GrantFiled: December 2, 2019Date of Patent: June 29, 2021Assignee: BASF SEInventors: Christian Degering, Thorsten Eggert, Stefan Evers, Karl-Heinz Maurer, Johannes Bongaerts
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Publication number: 20210163912Abstract: An amino acid sequence may have at least 70% sequence identity to the amino acid sequence identified in SEQ ID No. 1 over its entire length, and (a) an amino acid substitution on the position corresponding to the position 271, and (b1) at least one other amino acid substitution for at least one of the positions corresponding to the positions 18, 61, 92, 99, 137, 149, 156, 159, 162, 166, 172, 192, 199, 217, 265, or combinations thereof; and/or (b2) an amino acid substitution on the position corresponding to the position 9, and another amino acid substitution for at least one position corresponding to the positions 29, 48, 101, 130, 31, 133, 144, 217, 224, 252, or combinations thereof. Such proteases are useful for in washing or cleaning agents.Type: ApplicationFiled: September 5, 2018Publication date: June 3, 2021Inventors: Nina MUSSMANN, Susanne WIELAND, Daniela HERBST, Inken PRUESER, Christian DEGERING, Daria STRAUSS, Thorsten EGGERT, Christian LEGGEWIE, Layla FERNANDEZ, Sabine GRIEMERT
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Patent number: 10767142Abstract: The present disclosure relates to proteases having an amino acid sequence with at least about 70% sequence identity to the amino acid sequence given in SEQ ID NO:2, over the entire length thereof, and comprising an amino acid substitution at at least one of the positions P9, Q62, D101, N130, G166, N187, 5216, N238 or Q271, based in each case on the numbering according to SEQ ID NO:2. The present disclosure also relates to the production and use thereof. Such proteases exhibit very good stability, in particular storage stability, while at the same time having a good cleaning performance.Type: GrantFiled: March 7, 2017Date of Patent: September 8, 2020Assignee: Henkel AG & Co. KGaAInventors: Nina Mussmann, Timothy O'Connell, Daniela Herbst, Inken Prueser, Christian Degering, Sabine Griemert, Thorsten Eggert, Christian Leggewie
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Publication number: 20200231957Abstract: An amino acid sequence may have at least 70% sequence identity to the amino acid sequence identified in SEQ ID No. 1 over its entire length, and (a) amino acid substitutions at the positions corresponding to the positions 9 and 271 in each case based on the numbering according to SEQ ID No. 1, and (b) an amino acid substitution on at least one of the positions corresponding to the positions 29, 48, 101, 30, 131, 133, 144, 224 or 252, in each case based on the numbering according to SEQ ID No. 1. Such proteases are particularly suitable for having an improved cleaning performance.Type: ApplicationFiled: September 5, 2018Publication date: July 23, 2020Inventors: Layla FERNANDEZ, Sabine GRIEMERT, Nina MUSSMANN, Susanne WIELAND, Daniela HERBST, Inken PRUESER, Christian DEGERING, Daria STRAUSS, Thorsten EGGERT, Christian LEGGEWIE
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Publication number: 20200140787Abstract: The present disclosure relates to proteases having an amino acid sequence with at least about 70% sequence identity to the amino acid sequence given in SEQ ID NO:2, over the entire length thereof, and comprising an amino acid substitution at at least one of the positions P9, Q62, D101, N130, G166, N187, 5216, N238 or Q271, based in each case on the numbering according to SEQ ID NO:2. The present disclosure also relates to the production and use thereof. Such proteases exhibit very good stability, in particular storage stability, while at the same time having a good cleaning performance.Type: ApplicationFiled: March 7, 2017Publication date: May 7, 2020Applicant: Henkel AG & Co. KGaAInventors: Nina Mussmann, Timothy O?Connell, Daniela Herbst, Inken Prueser, Christian Degering, Sabine Griemert, Thorsten Eggert, Christian Leggewie
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Publication number: 20200095564Abstract: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a) a promoter sequence and b) a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified in SEQ ID NO: 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.Type: ApplicationFiled: December 2, 2019Publication date: March 26, 2020Applicant: BASF SEInventors: Christian Degering, Thorsten Eggert, Stefan Evers, Karl-Heinz Maure, Johannes Bongaerts
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Patent number: 10494622Abstract: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a) a promoter sequence and b) a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified in SEQ ID NO: 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.Type: GrantFiled: September 22, 2017Date of Patent: December 3, 2019Assignee: BASF SEInventors: Christian Degering, Thorsten Eggert, Stefan Evers, Karl-Heinz Maurer, Johannes Bongaerts
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Publication number: 20190112552Abstract: The present disclosure relates to proteases having an amino acid sequence with at least 70% sequence identity to the amino acid sequence given in SEQ ID No. 1, across its whole length, and comprising an amino acid substitution on at least one of the positions P9, Q10, Q62, L82, P86, N130, T141, N187, S236 or T253, relating in each case to the numbering according to SEQ ID No. 1. The present disclosure also relates to the production and use thereof. Said type of proteases have a very good cleaning performance.Type: ApplicationFiled: March 7, 2017Publication date: April 18, 2019Applicant: Henkel AG & Co. KGaAInventors: Nina Mussmann, Timothy O'Connell, Daniela Herbst, Inken Prueser, Christian Degering, Sabine Griemert, Thorsten Eggert, Christian Leggewie
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Publication number: 20180073005Abstract: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a) a promoter sequence and b) a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified in SEQ ID NO 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.Type: ApplicationFiled: September 22, 2017Publication date: March 15, 2018Applicant: BASF SEInventors: Christian Degering, Thorsten Eggert, Stefan Evers, Karl-Heinz Maurer, Johannes Bongaerts
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Patent number: 9803183Abstract: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a promoter sequence and a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified SEQ ID NO: 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.Type: GrantFiled: May 25, 2012Date of Patent: October 31, 2017Assignee: BASF SEInventors: Christian Degering, Thorsten Eggert, Stefan Evers, Karl-Heinz Maurer, Johannes Bongaerts
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Patent number: 9012227Abstract: The present invention relates to a cell, which has been genetically modified relative to its wild type, so that in comparison with its wild type it is able to produce more ?-aminocarboxylic acids, more ?-aminocarboxylic acid esters or more lactams derived from ?-aminocarboxylic acids, starting from carboxylic acids or carboxylic acid esters. Furthermore, the present invention relates to a method for the production of a genetically modified cell, the cells obtainable by this method, a method for the production of ?-aminocarboxylic acids, of ?-aminocarboxylic acid esters or of lactams derived from ?-aminocarboxylic acids, the ?-aminocarboxylic acids, ?-aminocarboxylic acid esters or lactams derived from ?-aminocarboxylic acids obtainable by this method, a method for the production of polyamides based on ?-aminocarboxylic acids or based on lactams and the polyamides obtainable by this method.Type: GrantFiled: December 12, 2008Date of Patent: April 21, 2015Assignee: Evonik Degussa GmbHInventors: Andreas Karau, Volker Sieber, Thomas Haas, Harald Haeger, Katrin Grammann, Bruno Buehler, Lars Blank, Andreas Schmid, Guido Jach, Bernd Lalla, Andreas Mueller, Katrin Schullehner, Peter Welters, Thorsten Eggert, Andrea Weckbecker
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Patent number: 8940516Abstract: The invention concerns a polypeptide which can be isolated from the Brassicaceae family and which has at least the activity of a hydroxynitrile lyase (HNL). The hydroxynitrile lyase of the invention is the first HNL from the Brassicaceae family. The plants (Arabidopsis) from which this enzyme or its gene is isolated is also described as non-cyanogenic. All HNL-containing plants described so far are cyanogenic plants and so it has until now been assumed that only cyanogenic plants contain hydroxynitrile lyases. Surprisingly, it transpires that a polypeptide (AtHNL) of the invention is (R)-selective. The amino acid sequence gives a theoretical molecular weight of 29.2 kDa for the AtHNL subunit. The calculated molecular mass of the protein of approximately 30 kDa can be confirmed by SDS gel electrophoresis.Type: GrantFiled: November 19, 2012Date of Patent: January 27, 2015Assignee: Evocatal GmbHInventors: Thorsten Eggert, Jennifer Andexer
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Publication number: 20140356929Abstract: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a) a promoter sequence and b) a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified in SEQ ID NO 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.Type: ApplicationFiled: May 25, 2012Publication date: December 4, 2014Applicant: BASF SEInventors: Christian Degering, Thorsten Eggert, Stefan Evers, Karl-Heinz Maurer, Johannes Bongaerts
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Patent number: 8580549Abstract: The invention relates to agents containing esterases, and to the use thereof for dressing fibres, in particular, artificial fibres, washing and cleaning agents comprising esterases and corresponding washing and cleaning methods, in addition to additional technical areas of application. The invention also relates to the use of esterases for protecting against or reducing and/or preventing pilling, preferably in textiles, particularly plastic fibres, more preferably polyester fibres, in addition to the use of esterases for separating the plastics, in particular, polyester compounds. The invention further relates to novel esterases and to sufficiently related proteins and to derivatives thereof, agents containing them and to the use thereof.Type: GrantFiled: August 3, 2006Date of Patent: November 12, 2013Assignee: Henkel KGaAInventors: Andreas Michels, André Pütz, Karl-Heinz Maurer, Thorsten Eggert, Karl-Erich Jäger
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Patent number: 8536314Abstract: The present invention provides variants of fluorescent proteins, which are improved with regard to their properties for use as reporter proteins and/or in analytics. In particular, variants of fluorescent proteins are provided, which fluoresce brighter, show improved quantum yield and/or have shifted excitation or emission spectra. The fluorescent proteins according to the invention comprise in their LOV domain besides the substitution of a cysteine with an amino acid that does not covalently bind FMN at least one further point mutation.Type: GrantFiled: May 19, 2010Date of Patent: September 17, 2013Assignee: Evocatal GmbHInventors: Thorsten Eggert, Sascha Hausmann, Michael Puls
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Publication number: 20100324257Abstract: The present invention relates to a cell, which has been genetically modified relative to its wild type, so that in comparison with its wild type it is able to produce more ?-aminocarboxylic acids, more ?-aminocarboxylic acid esters or more lactams derived from ?-aminocarboxylic acids, starting from carboxylic acids or carboxylic acid esters. Furthermore, the present invention relates to a method for the production of a genetically modified cell, the cells obtainable by this method, a method for the production of ?-aminocarboxylic acids, of ?-aminocarboxylic acid esters or of lactams derived from ?-aminocarboxylic acids, the ?-aminocarboxylic acids, ?-aminocarboxylic acid esters or lactams derived from ?-aminocarboxylic acids obtainable by this method, a method for the production of polyamides based on ?-aminocarboxylic acids or based on lactams and the polyamides obtainable by this method.Type: ApplicationFiled: December 12, 2008Publication date: December 23, 2010Applicant: EVONIK DEGUSSA GmbhInventors: Andreas Karau, Volker Sieber, Thomas Haas, Harald Haeger, Katrin Grammann, Bruno Buehler, Lars Blank, Andreas Schmid, Guido Jach, Bernd Lalla, Andreas Mueller, Katrin Schullehner, Peter Welters, Thorsten Eggert, Andrea Weckbecker
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Publication number: 20100304435Abstract: The present invention provides variants of fluorescent proteins, which are improved with regard to their properties for use as reporter proteins and/or in analytics. In particular, variants of fluorescent proteins are provided, which fluoresce brighter, show improved quantum yield and/or have shifted excitation or emission spectra. The fluorescent proteins according to the invention comprise in their LOV domain besides the substitution of a cysteine with an amino acid that does not covalently bind FMN at least one further point mutation.Type: ApplicationFiled: May 19, 2010Publication date: December 2, 2010Applicant: EVOCATAL GMBHInventors: Thorsten Eggert, Sascha Hausmann, Michael Puls