Patents by Inventor Thorsten Heinzel

Thorsten Heinzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF MOLECULAR MARKERS FOR THE PRECLINICAL PROFILING OF INHIBITORS OF ENZYMES HAVING HISTONE DEACETYLASE ACTIVITY
    Publication number: 20130231472
    Abstract: The present invention relates to the use of molecular markers and related signaling mechanisms for the preclinical and clinical profiling of inhibitors of enzymes having histone deacetylase activity. The invention also relates to the use of such markers as diagnostic and/or prognostic tools for the treatment of tumor patients with such inhibitors.
    Type: Application
    Filed: April 16, 2012
    Publication date: September 5, 2013
    Inventors: Thorsten HEINZEL, Oliver H. Kraemer, Martin Goettlicher, Ping Zhu, Martin Golebiewski, Pier Giuseppe Pelicci, Alexander B. Maurer, Bernd Hentsch, Saverio Minucci
  • Valproic acid and derivatives thereof as histone deacetylase inhibitors
    Publication number: 20070232696
    Abstract: The present invention relates to the use of the drug valproic acid and derivatives thereof as inhibitors of enzymes having histone deacetylase activity. The invention also relates to the use of those compounds for the manufacture of a medicament for the treatment of diseases which are associated with hypoacetylation of histones or in which induction of hyperacetylation has a beneficial effect for example by induction of differentiation and/or apoptosis in transformed cells.
    Type: Application
    Filed: January 17, 2007
    Publication date: October 4, 2007
    Inventors: Martin Gottlicher, Thorsten Heinzel, Bernd Groner, Peter Herrlich
  • Valproic acid and derivatives thereof as histone deacetylase inhibitors
    Patent number: 7265154
    Abstract: The present invention relates to the use of the drug valproic acid and derivatives thereof as inhibitors of enzymes having histone deacetylase activity. The invention also relates to the use of those compounds for the manufacture of a medicament for the treatment of diseases which are associated with hypoacetylation of histones or in which induction of hyperacetylation has a beneficial effect for example by induction of differentiation and/or apoptosis in transformed cells.
    Type: Grant
    Filed: July 5, 2001
    Date of Patent: September 4, 2007
    Assignee: Georg-Speyter-Haus Chemotherapeutisches Forschungsinstitut
    Inventors: Martin Göttlicher, Thorsten Heinzel, Bernd Groner, Peter Herrlich
  • Use of molecular markers for the preclinical and clinical profiling of inhibitors of enzymes having histone deacetylase activity
    Publication number: 20060110735
    Abstract: The present invention relates to the use of molecular markers and related signaling mechanisms for the preclinical and clinical profiling of inhibitors of enzymes having histone deacetylase activity. The invention also relates to the use of such markers as diagnostic and/or prognostic tools for the treatment of tumor patients with such inhibitors.
    Type: Application
    Filed: September 18, 2003
    Publication date: May 25, 2006
    Inventors: Thorsten Heinzel, Oliver Kraemer, Martin Goettlicher, Ping Zhu, Martin Golebiewski, Pier Pelicci, Alexander Maurer, Bernd Hentsch, Saverio Minucci
  • Valproic acid and derivatives for the combinatorial therapeutic treatment of human cancers and for the treatment of tumor metastasis and minimal residual disease
    Publication number: 20050038113
    Abstract: The present invention relates to the use of the drug valproic acid and derivatives thereof as inhibitors of enzymes having histone deacetylase for the sensitizing treatment of human cancers in combination with established therapeutic principles. The invention also relates to the use of those compounds for the treatment of tumor metastasis and minimal residual disease. The invention includes the manufacture of a clinically used substance for the treatment of human cancers.
    Type: Application
    Filed: September 17, 2002
    Publication date: February 17, 2005
    Applicant: G2M Cancer Drugs AG
    Inventors: Bernd Groner, Thorsten Heinzel, Bernd Hentsch, Winfried Wels, Peter Herrlich, Saverio Minucci, Pier Pelicci, Martin Gott Icher
  • Valproic acid and derivatives thereof as histone deacetylase inhibitors
    Publication number: 20040087652
    Abstract: The present invention relates to the use of the drug valproic acid and derivatives thereof as inhibitors of enzymes having histone deacetylase activity. The invention also relates to the use of those compounds for the manufacture of a medicament for the treatment of diseases which are associated with hypoacetylation of histones or in which induction of hyperacetylation has a beneficial effect for example by induction of differentiation and/or apoptosis in transformed cells.
    Type: Application
    Filed: August 11, 2003
    Publication date: May 6, 2004
    Inventors: Martin Gttlicher, Thorsten Heinzel, Bernd Groner, Peter Herrlich