Patents by Inventor Thorsten Oost

Thorsten Oost has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING
    Publication number: 20240174642
    Abstract: The present invention relates to compounds of formula (I) which are capable of activating STING (Stimulator of Interferon Genes). The present invention further relates to pharmaceutical compositions comprising at least a compound of formula (I), as well as the use of these compounds or the pharmaceutical compositions as a medicament, e.g., for treating canine or feline cancer, or as vaccine adjuvants.
    Type: Application
    Filed: October 24, 2023
    Publication date: May 30, 2024
    Inventors: Keith Andrew Newton GRAHAM, Sebastian CAROTTA, Georg DAHMANN, Cédrickx GODBOUT, Sandra Ruth HANDSCHUH, Herbert NAR, Thorsten OOST, Ulrich REISER, Esther SCHMIDT, Matthias TREU
  • HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING
    Publication number: 20240174641
    Abstract: The present invention relates to compounds of formula (I) which are capable of activating STING (Stimulator of Interferon Genes). The present invention further relates to pharmaceutical compositions comprising at least a compound of formula (I), as well as the use of these compounds or the pharmaceutical compositions as a medicament, e.g., for treating canine or feline cancer, or as vaccine adjuvants.
    Type: Application
    Filed: October 24, 2023
    Publication date: May 30, 2024
    Inventors: Keith Andrew Newton GRAHAM, Sebastian CAROTTA, Georg DAHMANN, Cédrickx GODBOUT, Sandra Ruth HANDSCHUH, Timo MISSEL, Herbert NAR, Thorsten OOST, Ulrich REISER, Esther SCHMIDT, Matthias TREU
  • HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING
    Publication number: 20240166629
    Abstract: The present invention relates to heterocyclic compounds of formula (I) capable of activating STING (Stimulator of Interferon Genes).
    Type: Application
    Filed: October 24, 2023
    Publication date: May 23, 2024
    Inventors: Ulrich REISER, Sebastian CAROTTA, Georg DAHMANN, Cédrickx GODBOUT, Sandra Ruth HANDSCHUH, Herbert NAR, Thorsten OOST, Matthias TREU
  • Substituted 1,2,4-oxadiazoles as TRPA1 inhibitors
    Patent number: 11878981
    Abstract: The present disclosure provides certain substituted 1,2,4-oxadiazole derivatives of the below formula (I) that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Grant
    Filed: April 13, 2022
    Date of Patent: January 23, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Florian Paul Christian Binder, Georg Dahmann, Martin Thomas Fleck, Annekatrin Charlotte Heimann, Thorsten Oost
  • METHODS FOR TREATING PULMONARY EMPHYSEMA USING SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C
    Publication number: 20230310373
    Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
    Type: Application
    Filed: June 8, 2023
    Publication date: October 5, 2023
    Inventors: Ralf ANDERSKEWITZ, Florian BINDER, Matthias GRAUERT, Marc GRUNDL, Peter Wilhelm HAEBEL, Thorsten OOST, Alexander PAUTSCH, Stefan PETERS, Viktor VINTONYAK
  • HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING
    Publication number: 20220388986
    Abstract: The present invention relates to heterocyclic compounds of formula (I) capable of activating STING (Stimulator of Interferon Genes).
    Type: Application
    Filed: April 27, 2022
    Publication date: December 8, 2022
    Inventors: Sebastian CAROTTA, Georg DAHMANN, Cédrickx GODBOUT, Sandra Ruth HANDSCHUH, Herbert NAR, Thorsten OOST, Ulrich REISER, Matthias TREU
  • IMIDAZO[4,5-D]PYRIDAZINONYL DERIVATIVES AS TRPA1 INHIBITORS
    Publication number: 20220340580
    Abstract: The present disclosure provides certain imidazo[4,5-d]pyridazinonyl derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: April 13, 2022
    Publication date: October 27, 2022
    Inventors: Florian Paul Christian BINDER, Georg DAHMANN, Martin Thomas FLECK, Annekatrin Charlotte HEIMANN, Thorsten OOST
  • METHODS FOR TREATING PULMONARY EMPHYSEMA USING SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C
    Publication number: 20210260027
    Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
    Type: Application
    Filed: April 19, 2021
    Publication date: August 26, 2021
    Inventors: Ralf ANDERSKEWITZ, Florian BINDER, Matthias GRAUERT, Marc GRUNDL, Peter Wilhelm HAEBEL, Thorsten OOST, Alexander PAUTSCH, Stefan PETERS, Viktor VINTONYAK
  • MODIFIED CYCLIC DINUCLEOTIDE COMPOUNDS
    Publication number: 20210024567
    Abstract: Compounds of formula (I) wherein Base, R1 and R2 are defined as in claim 1, are modulators of STING.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 28, 2021
    Inventors: Thorsten OOST, Martin FLECK, Christian Andreas KUTTRUFF
  • CYCLIC DINUCLEOTIDE COMPOUNDS CONTAINING 2-AZA-HYPOXANTHINE OR 6H-PYTAZOLO[1,5-D][1,2,4]TRIZAIN-7-ONE AS STRING AGONISTS
    Publication number: 20210009627
    Abstract: Compounds of formula I, wherein Base, R1 and R2 are defined as in claim 1, are modulators of STING.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 14, 2021
    Inventors: Annekatrin Charlotte HEIMANN, Martin FLECK, Christian Andreas KUTTRUFF, Thorsten OOST
  • METHODS FOR TREATING PULMONARY EMPHYSEMA USING SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C
    Publication number: 20200138780
    Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
    Type: Application
    Filed: December 19, 2019
    Publication date: May 7, 2020
    Inventors: Ralf ANDERSKEWITZ, Florian BINDER, Matthias GRAUERT, Marc GRUNDL, Peter Wilhelm HAEBEL, Thorsten OOST, Alexander PAUTSCH, Stefan PETERS, Viktor VINTONYAK
  • Cyclic dinucleotide compounds
    Patent number: 10537590
    Abstract: The present invention relates to compounds of general formula I, wherein the groups R1, R2 and R3 are defined as in claim 1, which have valuable pharmacological properties, particularly are modulators of STING.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: January 21, 2020
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thorsten Oost, Sebastian Carotta, Martin Fleck
  • Modified cyclic dinucleotide compounds
    Patent number: 10392419
    Abstract: Compounds of formula (I) wherein Base1 and Base2 are defined as in claim 1 are modulators of STING.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: August 27, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thorsten Oost, Martin Fleck, Christian Andreas Kuttruff, Sebastian Carotta
  • METHODS FOR TREATING PULMONARY EMPHYSEMA USING SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C
    Publication number: 20190167636
    Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
    Type: Application
    Filed: February 8, 2019
    Publication date: June 6, 2019
    Inventors: Ralf ANDERSKEWITZ, Florian BINDER, Matthias GRAUERT, Marc GRUNDL, Peter Wilhelm HAEBEL, Thorsten OOST, Alexander PAUTSCH, Stefan PETERS, Viktor VINTONYAK
  • Methods for treating pulmonary emphysema using substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of Cathepsin C
    Patent number: 10238633
    Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: March 26, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Ralf Anderskewitz, Florian Binder, Matthias Grauert, Marc Grundl, Peter Wilhelm Haebel, Thorsten Oost, Alexander Pautsch, Stefan Peters, Viktor Vintonyak
  • MODIFIED CYCLIC DINUCLEOTIDE COMPOUNDS
    Publication number: 20180273578
    Abstract: Compounds of formula (I) wherein Base1 and Base2 are defined as in claim 1 are modulators of STING.
    Type: Application
    Filed: March 20, 2018
    Publication date: September 27, 2018
    Inventors: Thorsten OOST, Martin FLECK, Christian Andreas KUTTRUFF, Sebastian CAROTTA
  • CYCLIC DINUCLEOTIDE COMPOUNDS
    Publication number: 20180092937
    Abstract: The present invention relates to compounds of general formula I, wherein the groups R1, R2 and R3 are defined as in claim 1, which have valuable pharmacological properties, particularly are modulators of STING.
    Type: Application
    Filed: September 27, 2017
    Publication date: April 5, 2018
    Inventors: Thorsten OOST, Sebastian CAROTTA, Martin FLECK
  • METHODS FOR TREATING PULMONARY EMPHYSEMA USING SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C
    Publication number: 20170266160
    Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
    Type: Application
    Filed: June 6, 2017
    Publication date: September 21, 2017
    Inventors: Ralf ANDERSKEWITZ, Florian BINDER, Matthias GRAUERT, Marc GRUNDL, Peter Wilhelm HAEBEL, Thorsten OOST, Alexander PAUTSCH, Stefan PETERS, Viktor VINTONYAK
  • Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
    Patent number: RE46630
    Abstract: This invention relates to substituted 4-pyridones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other auto-immune and allergic disorders, allograft rejection, and oncological diseases.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: December 12, 2017
    Assignee: Boehringer Ingelhelheim International GmbH
    Inventors: Thorsten Oost, Dennnis Fiegen, Christian Gnamm, Sandra Handschuh, Stefan Peters, Gerald Juergen Roth
  • Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
    Patent number: RE47493
    Abstract: This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: July 9, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Christian Gnamm, Thorsten Oost, Stefan Peters, Klaus Rudolf