Abstract: The present disclosure relates to a vehicle, a method, a device and a steering system for a vehicle. In particular, the disclosure relates to a device for a vehicle with a first direct voltage source and at least one second direct voltage source, which are connected in series, for operating a consumer in the vehicle. The device comprises a potential tap which is designed to tap a potential between the first and the second direct voltage source. The device further comprises a circuit which is designed to provide the potential tapped between the first and the second direct voltage source for operating the consumer in the event of a fault in the first or second direct voltage source.

Abstract: The present invention relates to novel compounds for the treatment of Hepatitis C.

Abstract: The disclosure relates to a method to estimate dynamic loads acting vertically on a rear axle of a motor vehicle during a forward driving operation. To enable an estimation of the dynamic loads acting vertically on the rear axle during the forward driving operation of the motor vehicle cost-effectively, the dynamic loads are estimated in consideration of dynamic mechanical forces engaging vertically at a front axle of the motor vehicle during the forward driving operation. In addition, dynamic acceleration forces engaging at a spring mass of the motor vehicle during the forward driving operation are also considered when estimating the dynamic loads during the forward driving operation.

Abstract: A process for preparing a compound of formula (I) or a salt thereof, the process comprising providing a compound of formula (III) wherein PG is an inert electron withdrawing hydroxyl protecting group, reacting the compound of formula (III) with a fluorinating agent, obtaining a compound of formula (II) and deprotecting the compound of formula (II).

Abstract: A process for preparing a compound of formula (I) or a salt thereof, the process comprising providing a compound of formula (III) wherein PG is an inert electron withdrawing hydroxyl protecting group, reacting the compound of formula (III) with a fluorinating agent, obtaining a compound of formula (II) and deprotecting the compound of formula (II).

Abstract: A process for preparing a nucleoside phosphoramidate, in particular to a process for preparing sofosbuvir, wherein a phosphoramidate derivative is used as starting material.

Abstract: A process comprising (i) providing a mixture comprising a compound of formula (I) or isomers, stereoisomers, diastereomers, enantiomers or salts thereof; (ii) subjecting the mixture provided in (i) to fluorinating conditions in the presence of a fluorination agent selected from the group consisting of diethylamino (difluoro) sulfonium tetrafluoroborate and difluoro(morpholino) sulfonium tetrafluoroborate obtaining a mixture comprising a compound of formula (II) or isomers, stereoisomers diastereomers, enantiomers or salts thereof; (iii) optionally subjecting the mixture obtained in (ii) to deprotection conditions, obtaining a mixture comprising the compound of formula (III) or isomers, stereoisomers, diastereomers, enantiomers or salts thereof.

Abstract: A process for the preparation of a compound of formula (I) including all isomers, stereoisomers, enantiomers and diastereomers thereof (I), and salts thereof; the process comprising providing a mixture comprising a compound of formula (II) and a compound of formula (III) subjecting the mixture provided in a) to reaction conditions in the presence of one or more Lewis acids to the mixture provided in a), obtaining a mixture comprising the compound of formula (I).

Abstract: A steering system is provided to support a straight running of a vehicle. The steering system included an active steering assistance system, a support torque section, and a correction section. The support torque section is configured to calculate a supporting torque based on a steering torque applied to a steering wheel of the vehicle. The correction section is configured to calculate a correcting torque on a basis of a progressively calculated supporting torque. The active steering assistance is configured to be controlled on the basis of a control torque based upon a superimposition of the supporting torque with the correcting torque.

Abstract: The present invention relates to a process for the preparation of a compound of formula (V), in particular posaconazole, wherein said process comprises the steps of (1) providing a mixture comprising a compound of formula (IV), a protic solvent system, and a suitable base; and (2) heating the mixture of (1) to obtain a mixture comprising the compound of formula (V).

Abstract: It is provided an improved process for preparing peptide epoxy ketones, including novel compounds that can be used as intermediates in the process for preparing Carfilzomib and other peptide epoxy ketones.

Abstract: It is provided an improved process for preparing Carfilzomib, including novel compounds that can be used as intermediates in the process for preparing Carfilzomib.

Abstract: The present invention provides a new method of separating epothilones from one another that can be used on an industrial scale for the selective enrichment of epothilone and to provide a crystalline solid of enhanced purity, which can be used for the production of pharmaceutical preparations without using normal or reverse-phase chromatography or any energy input via distillation apparatus, wherein the new method comprises the steps: a. dissolving a crude containing epothilones in an nonpolar protic solvent, b. adding an amount of a polar protic anti-solvent to form a slurry, c. isolating a crystalline solid from the slurry.

Abstract: The invention relates to synthetic routes for preparing telaprevir and boceprevir, and its intermediates as well as peptides other than telaprevir. The synthetic routes are based on a Mukaiyama aldol addition reaction of a silyl enol ether or an enolate with an imine. The invention also refers to novel intermediates for preparing telaprevir/boceprevir or other peptides.

Abstract: A steering system to control a directional stability of a vehicle may include an active power steering assistance system, a sensor to detect vehicle dynamics data of the vehicle, a sensor to detect a torque of a steering system of the vehicle, and a controller. The controller may be configured to determine a torque value based on the vehicle dynamics data, calculate a torque component based on a difference between the torque value and the torque of the steering system, calculate a preliminary compensation torque on a basis of the torque component, calculate a final compensation torque by adding the preliminary compensation torque and the torque value, and actuate the active power steering assistance system based upon the final compensation torque. Systems and methods for controlling directional stability of a vehicle may compensate for short-term pull/drift and long-term pull/drift.

Abstract: The invention relates to synthetic routes for preparing telaprevir and boceprevir, and its intermediates as well as peptides other than telaprevir. The synthetic routes are based on a Mukaiyama aldol addition reaction of a silyl enol ether or an enolate with an imine. The invention also refers to novel intermediates for preparing telaprevir/boceprevir or other peptides.

Abstract: A process for the preparation of a chiral compound, in particular posaconazole, wherein the process comprises mixing and reacting the compounds of formula (I) Y3—NH2; of formula (IIa) 0=C?N—Y0 and/or of formula (IIb) and of formula (III) in a solvent in any order to obtain a reaction mixture containing a chiral compound of formula (IV) and/or formula (V).

Abstract: A steering system is provided to support a straight running of a vehicle. The steering system included an active steering assistance system, a support torque section, and a correction section. The support torque section is configured to calculate a supporting torque based on a steering torque applied to a steering wheel of the vehicle. The correction section is configured to calculate a correcting torque on a basis of a progressively calculated supporting torque. The active steering assistance is configured to be controlled on the basis of a control torque based upon a superimposition of the supporting torque with the correcting torque.

Abstract: The invention relates to a process for the preparation of telaprevir, or a pharmaceutically acceptable salt or solvate thereof, wherein the process requires a smaller number of process steps and/or does not require the use of toxic and instable compounds compared to the known processes. Another embodiment refers to telaprevir, or a pharmaceutically acceptable salt or solvate thereof as well as to intermediate products for preparation of the same, wherein the afore-mentioned products are obtained by the process described herein.

Abstract: A steering system to control a directional stability of a vehicle may include an active power steering assistance system, a sensor to detect vehicle dynamics data of the vehicle, a sensor to detect a torque of a steering system of the vehicle, and a controller. The controller may be configured to determine a torque value based on the vehicle dynamics data, calculate a torque component based on a difference between the torque value and the torque of the steering system, calculate a preliminary compensation torque on a basis of the torque component, calculate a final compensation torque by adding the preliminary compensation torque and the torque value, and actuate the active power steering assistance system based upon the final compensation torque. Systems and methods for controlling directional stability of a vehicle may compensate for short-term pull/drift and long-term pull/drift.