Abstract: The present invention relates to a 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignan compound which activates nutmeg-derived AMP-activated protein kinase (AMPK), and to a composition including same as active ingredients for preventing and treating metabolic syndromes such as obesity. More particularly, the present invention relates to an AMPK-activating compound comprising one of the 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignan-based compounds produced by extracting Myristica fragrans with a solution of 30% or less of ethanol and separating and purifying the extracts using chromatography, as expressed in chemical formula 1 below, and to a composition comprising same as an active ingredient for preventing and treating metabolic syndrome caused by AMPK enzyme activation, such as obesity, diabetes, high cholesterol and cardiopulmonary diseases.

Abstract: Mobile device software is managed by providing an interface between a plurality of software module handlers and a plurality of software modules. The interface is invoked responsive to a software module event such as the installation, removal, activation or modification of a software module. The interface identifies the software module and a corresponding attribute list associated with the software module event. The attribute list specifies one or more actions to be taken by at least one of the software module handlers that enable the identified software module to provide one or more functions when invoked. The attribute list is provided to each software module handler identified in the list and each action specified in the list is taken by the corresponding software module handler. This way, the interface reliably manages the different software modules without being aware of the particular functions provided by the modules or the specific actions taken by the handlers.

Abstract: Method and system for extending and/or modifying functionality of a platform for a product, such as a mobile terminal for a wireless telecommunications system. The system includes a platform domain having a software services component for providing functionality, and an interface component having at least one interface for providing access to the software services component for enabling application software to be installed, loaded and run in said platform via the at least one interface. The system also includes plug-in software for use together with the application software for extending and/or modifying the functionality of the software services component of the platform domain via the at least one interface.

Abstract: System and method for transmitting messages between first and second software components such as application software and software of a platform for a product. An exemplary system includes a platform having a software component and an interface component having an interface for providing an application or a module in an application domain with access to the software component. The system further includes a message transmitting mechanism for transmitting messages between the application or the module and the platform via the interface that includes a message model for allowing an application to select either a callback mode or a full message mode for receiving messages between the application or the module and the platform, and a message handler for routing messaging according to the selected mode.

Abstract: A middleware services layer for a platform system for a mobile terminal for a wireless telecommunications system, the platform system including a mobile terminal platform assembly having a software services component, and application software loaded, installed and run in said mobile terminal platform assembly. The middleware services layer comprises at least one application programming interface (API) for providing access to the mobile terminal platform assembly for loading, installing and running application software in said mobile terminal platform assembly; and, at the same time, isolates the platform assembly from the applications via the at least one API.

Abstract: A software application framework includes a framework interface domain for interfacing a platform domain with application domain software of an application domain. The framework also includes a software application domain that includes a first application entity. The first application entity is adapted to interact with at least one of a second application entity, the framework interface domain, at least one utility entity, and at least one plug-in entity.

Abstract: A software application framework includes a framework interface domain for interfacing a platform domain with application domain software of an application domain. The framework also includes a software application domain that includes a first application entity. The first application entity is adapted to interact with at least one of a second application entity, the framework interface domain, at least one utility entity, and at least one plug-in entity.

Abstract: A suture anchor is described which in one form may be easily fabricated from extruded material by angular cuts and bore holes which provide an offset pulling force to the suture. In an alternate and preferred embodiment the suture anchor is injection molded having an annular displaced corner and abutment wall which act to seat the suture anchor firmly within a bore hole. Novel application means are also disclosed which hold the suture anchor on a frangible shaft for insertion and upon completion of the insertion permit fracture of the frangible portion and removal of the instrument.

Abstract: The present invention provides a network enabled multi-user configurable optical storage server. The device is easy to install and does not require client or server software. The server can be configured across a network through a series of HTML based web pages, or graphical user interfaces (GUI) provided by the server. The server can be accessed across a network by one or more users, terminals, or other network attached devices for substantially concurrent read/write access to one or more optical storage media. The server supports a comprehensive set of networking protocols and operating systems simultaneously. The server may support from one to hundreds of CD/DVD-ROMS. In an embodiment of the invention the server includes two stages of writing prior to committing to a write to the physical medium. This speeds both read and write access to the disk, allows concurrent user access to the disk, and greatly simplifies the mapping and file structures on the disk.

Abstract: System and method for transmitting messages between first and second software components such as application software and software of a platform for a product. An exemplary system includes a platform having a software component and an interface component having an interface for providing an application or a module in an application domain with access to the software component. The system further includes a message transmitting mechanism for transmitting messages between the application or the module and the platform via the interface that includes a message model for allowing an application to select either a callback mode or a full message mode for receiving messages between the application or the module and the platform, and a message handler for routing messaging according to the selected mode.

Abstract: Method and system for extending and/or modifying functionality of a platform for a product, such as a mobile terminal for a wireless telecommunications system. The system includes a platform domain having a software services component for providing functionality, and an interface component having at least one interface for providing access to the software services component for enabling application software to be installed, loaded and run in said platform via the at least one interface. The system also includes plug-in software for use together with the application software for extending and/or modifying the functionality of the software services component of the platform domain via the at least one interface.

Abstract: A software application framework includes a framework interface domain for interfacing a platform domain with application domain software of an application domain. The framework also includes a software application domain that includes a first application entity. The first application entity is adapted to interact with at least one of a second application entity, the framework interface domain, at least one utility entity, and at least one plug-in entity.

Abstract: A middleware services layer for a platform system for a mobile terminal for a wireless telecommunications system, the platform system including a mobile terminal platform assembly having a software services component, and application software loaded, installed and run in said mobile terminal platform assembly. The middleware services layer comprises at least one application programming interface (API) for providing access to the mobile terminal platform assembly for loading, installing and running application software in said mobile terminal platform assembly; and, at the same time, isolates the platform assembly from the applications via the at least one API.

Abstract: Osteopontin (OPN) levels measured in bodily fluids of cancer patients are used as a noninvasive marker for tumor hypoxia as described herein. Methods of using OPN levels for the diagnosis, prognosis and treatment of cancers characterized by the presence of hypoxic cells, and a kit for detecting the presence of a hypoxic tumor are provided.

Abstract: The present invention provides a network enabled multi-user configurable optical storage server. The device is easy to install and does not require client or server software. The server can be configured across a network through a series of HTML based web pages, or graphical user interfaces (GUI) provided by the server. The server can be accessed across a network by one or more users, terminals, or other network attached devices for substantially concurrent read/write access to one or more optical storage media. The server supports a comprehensive set of networking protocols and operating systems simultaneously. The server may support from one to hundreds of CD/DVD-ROMS. In an embodiment of the invention the server includes two stages of writing prior to committing to a write to the physical medium. This speeds both read and write access to the disk, allows concurrent user access to the disk, and greatly simplifies the mapping and file structures on the disk.

Abstract: A suture anchor device having an anchor member with outwardly extending wing members and an actuating wedge member. The suture anchor device is inserted into a bore hole in a bone as part of an orthopedic surgical procedure wherein soft tissue such as a tendon or ligament is attached to the surface of the bone. The wing members are spread outwardly by the wedge member to lock the suture anchor device in the bone. The suture anchor has similar utility in soft tissue applications.

Abstract: A two-piece suture anchor is disclosed wherein a barrel-like main portion is provided with a pair of legs in a central opening. A ball-like actuating device is received within the central opening and drawn upward into the device in order to separate the legs and cause the device to expand into the soft cancellous bone of a previously prepared bone site.

Abstract: A method of tissue compression is disclosed herein where the device to cause such compression is composed of a fastener bar and receiver. The device has the capability to self-adjust to tissues of varying thicknesses to cause hemostasis. This tissue gap variability allows for compression of regions of tissue where thick and thin tissue are both present. This variability also enables the same device to be used on a wide variety of tissues of different thicknesses. The tissue fastener bar of this invention contains a series of cut-out portions which distribute the compressive forces along the device in an alternating, staggered manner. The receiver is of a generally U-shaped configuration with the fastener bar being contained at least partially within the U-shape. Compression occurs between the side walls of the receiver and the fastener bar and variability in gap is accomplished by flexure of the side walls of the receiver.