Abstract: The present disclosure provides for improved methods for expanding tumor infiltrating lymphocytes (TILs) and producing therapeutic populations of TILs in a shorter time period than the traditional methods. TIL cell therapy products can be manufactured which easily meet the target cell dose while maintaining desired T cell phenotype.

Abstract: A method for wafer treatment is disclosed. A wafer is provided with a main surface, a surface layer, and a base layer. The surface layer is disposed between the main surface and the base layer, and the surface layer covers the base layer and exposes the main surface. Then, at least one laser process is performed to fully irradiate the main surface and the surface layer with a first laser to generate a plurality of optimized regions in the main surface and the surface layer, so that the optimized regions form at least one stress-relieving array.

Abstract: A method for a wafer treatment includes providing a wafer including a main surface, a surface layer and a base layer; and performing at least one laser process to irradiate the whole surface layer with laser to thereby generate a plurality of defect regions in the surface layer, and the defect regions form at least one array of defect regions.

Abstract: A method for wafers treatment is disclosed. First, a wafer including a wafer base is provided, where the wafer base includes a surface layer. Second, a first laser process is performed, wherein the surface layer of the wafer is irradiated with a first laser to modify the surface layer. The first laser is associated with a first parameter group. Next, a second laser process is performed, wherein the surface layer of the wafer is irradiated with a second laser to modify the surface layer. The second laser is associated with a second parameter group. Modification of the surface layer includes at least one of removing the surface layer, changing the crystallinity of the surface layer, or changing the surface roughness of the surface layer. The first parameter group corresponds to the second parameter group.

Abstract: The invention relates to biting arthropod repellent compositions comprising nootkatone. The application also relates to a method of repelling said biting arthropods by application of the nootkatone composition to a hard or soft surface, to a method of treating an arthropod infestation and to a method of reducing the transmission of a parasite or disease pathogen spread by a biting arthropod using the nootkatone composition.

Abstract: A method of allocating space on a spectrum on which information is transmitted, to information to be transmitted, the method comprising: identifying carrier frequencies and bandwidths of information being transmitted on the spectrum, determining an optimal carrier frequency and bandwidth for the information to be transmitted based on the carrier frequencies and bandwidths of information being transmitted on the spectrum; transmitting the information to be transmitted using modulation at the identified optimal carrier frequency and bandwidth.

Abstract: A method of analysing a spectrum on which information is transmitted, comprising: determining each different type of modulation used for transmitting the information across the spectrum, for each determined modulation, identifying its carrier frequency and its bandwidth, defining characteristics of usage of the spectrum in terms of the determined modulations and their corresponding carrier frequencies and bandwidths.

Abstract: The present invention relates to a method for producing tetrahydridoborate salts with high efficiency at low cost. The method for the production of metal borohydride salts according to the present invention comprises the steps of providing an anhydrous metal borate salt and milling the anhydrous metal borate salt in the presence of a metal material based on magnesium or magnesium alloys in a hydrogen atmosphere at a temperature and for a time sufficient to produce the metal borohydride salt. In another embodiment of the invention, the method for the production of metal borohydride salts according to the present invention comprises the steps of providing an hydrated metal borate salt and milling the hydrated metal borate salt in the presence of a metal material based on magnesium or magnesium alloys in an inert gas atmosphere at a temperature and for a time sufficient to produce the metal borohydride salts.

Abstract: Both purinergic signaling through nucleotides such as ATP and noradrenergic signaling through molecules such as norepinephrine regulate vascular tone and blood pressure. Pannexin1 (Panx1), which forms large-pore, ATP-releasing channels, is present in vascular smooth muscle cells in peripheral blood vessels and participates in noradrenergic responses. Using pharmacological approaches and mice conditionally lacking Panx1 in smooth muscle cells, we found that Panx1 contributed to vasoconstriction mediated by the ?1 adrenoreceptor (?1AR), whereas vasoconstriction in response to serotonin or endothelin-1 was independent of Panx1. Analysis of the Panx1-deficient mice showed that Panx1 contributed to blood pressure regulation especially during the night cycle when sympathetic nervous activity is highest. Using mimetic peptides and site-directed mutagenesis, we identified a specific amino acid sequence in the Panx1 intracellular loop that is essential for activation by ?1AR signaling.

Abstract: The invention relates to biting arthropod repellent compositions comprising nootkatone. The application also relates to a method of repelling said biting arthropods by application of the nootkatone composition to a hard or soft surface, to a method of treating an arthropod infestation and to a method of reducing the transmission of a parasite or disease pathogen spread by a biting arthropod using the nootkatone composition.

Abstract: The invention relates to biting arthropod repellent compositions comprising nootkatone. The application also relates to a method of repelling said biting arthropods by application of the nootkatone composition to a hard or soft surface, to a method of treating an arthropod infestation and to a method of reducing the transmission of a parasite or disease pathogen spread by a biting arthropod using the nootkatone composition.

Abstract: The present invention relates to a method for producing tetrahydridoborate salts with high efficiency at low cost. The method for the production of metal borohydride salts according to the present invention comprises the steps of providing an anhydrous metal borate salt and milling the anhydrous metal borate salt in the presence of a metal material based on magnesium or magnesium alloys in a hydrogen atmosphere at a temperature and for a time sufficient to produce the metal borohydride salt. In another embodiment of the invention, the method for the production of metal borohydride salts according to the present invention comprises the steps of providing an hydrated metal borate salt and milling the hydrated metal borate salt in the presence of a metal material based on magnesium or magnesium alloys in an inert gas atmosphere at a temperature and for a time sufficient to produce the metal borohydride salts.

Abstract: An in-wall amplifier assembly includes a wireless communication device and an amplifier located inside a first housing configured for in-wall installation, with the amplifier configured to amplify the audio output from the wireless communication device and supply it to external speakers. An AC/DC adapter located in a second housing can be connected thereto to supply DC power to the amplifier and wireless communication device. The wireless communication device can be removably accommodated in a faceplate of the first housing and held in place by a wall plate installed thereover. The amplifier can accept an external audio input from another source and automatically switch the amplified audio output between the output of the wireless communication device and the external audio input.

Abstract: The present invention relates to a preparation method of a matrix of rice husk silica for immobilizing enzyme wherein a rice husk silica is modified with APTES((3-aminopropyl)triethoxysilane) and glutaraldehyde, a matrix of rice husk silica for immobilizing enzyme prepared by said method, a rice husk silica-enzyme complex wherein enzyme is immobilized onto said matrix of rice husk silica and a preparation method of valuable substances using said rice husk silica-enzyme complex. The rice husk silica having a nanoporous structure cannot only facilitate diffusion of substrate during enzyme reaction but also can be utilized as a path through which intermediates from the consecutive enzyme reactions can travel. Therefore, it can be effectively utilized in preparing valuable substances.

Abstract: Both purinergic signaling through nucleotides such as ATP and noradrenergic signaling through molecules such as norepinephrine regulate vascular tone and blood pressure. Pannexin1 (Panx1), which forms large-pore, ATP-releasing channels, is present in vascular smooth muscle cells in peripheral blood vessels and participates in noradrenergic responses. Using pharmacological approaches and mice conditionally lacking Panx1 in smooth muscle cells, we found that Panx1 contributed to vasoconstriction mediated by the ?1 adrenoreceptor (?1AR), whereas vasoconstriction in response to serotonin or endothelin-1 was independent of Panx1. Analysis of the Panx1-deficient mice showed that Panx1 contributed to blood pressure regulation especially during the night cycle when sympathetic nervous activity is highest. Using mimetic peptides and site-directed mutagenesis, we identified a specific amino acid sequence in the Panx1 intracellular loop that is essential for activation by ?1AR signaling.

Abstract: The present disclosure provides methods of increasing proliferation of adult salivary stem cells. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with an aldehyde dehydrogenase (ALDH) agonist. Increasing proliferation of adult salivary stem cells can be carried out to provide for an increase in the number of adult salivary stem cells in an individual undergoing radiotherapy for head and neck cancer.

Abstract: An in-wall amplifier assembly includes a wireless communication device and an amplifier located inside a first housing configured for in-wall installation, with the amplifier configured to amplify the audio output from the wireless communication device and supply it to external speakers. An AC/DC adapter located in a second housing can be connected thereto to supply DC power to the amplifier and wireless communication device. The wireless communication device can be removably accommodated in a faceplate of the first housing and held in place by a wall plate installed thereover. The amplifier can accept an external audio input from another source and automatically switch the amplified audio output between the output of the wireless communication device and the external audio input.

Abstract: Both purinergic signaling through nucleotides such as ATP and noradrenergic signaling through molecules such as norepinephrine regulate vascular tone and blood pressure. Pannexin1 (Panx1), which forms large-pore, ATP-releasing channels, is present in vascular smooth muscle cells in peripheral blood vessels and participates in noradrenergic responses. Using pharmacological approaches and mice conditionally lacking Panx1 in smooth muscle cells, we found that Panx1 contributed to vasoconstriction mediated by the ?1 adrenoreceptor (?1AR), whereas vasoconstriction in response to serotonin or endothelin-1 was independent of Panx1. Analysis of the Panx1-deficient mice showed that Panx1 contributed to blood pressure regulation especially during the night cycle when sympathetic nervous activity is highest. Using mimetic peptides and site-directed mutagenesis, we identified a specific amino acid sequence in the Panx1 intracellular loop that is essential for activation by ?1AR signaling.

Abstract: The invention relates to biting arthropod repellent compositions comprising nootkatone. The application also relates to a method of repelling said biting arthropods by application of the nootkatone composition to a hard or soft surface, to a method of treating an arthropod infestation and to a method of reducing the transmission of a parasite or disease pathogen spread by a biting arthropod using the nootkatone composition.

Abstract: The present disclosure provides methods of increasing proliferation of adult salivary stem cells, methods of protecting adult salivary stem cells and improving salivary gland function. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with a therapeutically effective amount of at least one isolated monoterpene and subjecting the adult salivary stem cells to radiation treatment. Increasing proliferation of adult salivary stem cells can be carried out to provide for an increase in the number of adult salivary stem cells and improve salivary gland function in an individual undergoing radiotherapy for head and neck cancer. The methods also include treating an individual with dry eye with a therapeutically effective amount of at least one isolated monoterpene.