Patents by Inventor Thu Phan

Thu Phan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250136558
    Abstract: Disclosed herein are heterocyclic compounds that inhibit the activity of FLT3. Also described are specific irreversible inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.
    Type: Application
    Filed: August 19, 2022
    Publication date: May 1, 2025
    Inventors: Thomas Butler, James T. Palmer, David Sperandio, Xiaodong Wang, Nan-Horng Lin, Thorsten A. Kirschberg, Solomon B. Ungashe, Neil Howard Squires, Ravindra B. Upasani, Yongli Su, Thu Phan, Amna Trinity-Turjuman Adam
  • Publication number: 20250066386
    Abstract: Disclosed herein are macrocyclic compounds that inhibit the binding of KRas. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the KRas inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia, lung cancer, colorectal cancer, pancreatic cancer, and other diseases or conditions dependent on KRas interaction.
    Type: Application
    Filed: November 8, 2022
    Publication date: February 27, 2025
    Inventors: Thorsten A. Kirschberg, Solomon B. Ungashe, Thu Phan, Yongli Su, Xiaodong Wang, James T. Palmer, Thomas Butler, Ravindra B. Upasani, Nan-Horng Lin, David Sperandio, Neil Howard Squires, Amna Trinity-Turjuman Adam
  • Publication number: 20240409558
    Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of KRas. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the KRas inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia, lung cancer, colorectal cancer, pancreatic cancer, and other diseases or conditions dependent on KRas interaction.
    Type: Application
    Filed: September 12, 2022
    Publication date: December 12, 2024
    Inventors: Yongli Su, Thu Phan, Thomas Butler, James T. Palmer, Solomon Ungashe, Ravindra B. Upassani, Neil Howard Squires, David Sperandio, Thorsten A. Kirschberg, Xiaodong Wang, Brian Law, Nan-Horng Lin
  • Publication number: 20240262795
    Abstract: Disclosed herein are heterocyclic compounds that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.
    Type: Application
    Filed: February 13, 2024
    Publication date: August 8, 2024
    Inventors: David Sperandio, Xiaodong Wang, Thorsten A. Kirschberg, James T. Palmer, Thomas Butler, Solomon B. Ungashe, Neil Howard Squires, Nan-Horng Lin, Ravindra B. Upasani, Amna Trinity-Turjuman Adam, Yongli Su, Thu Phan
  • Patent number: 11945785
    Abstract: Disclosed herein are heterocyclic compounds, for example, according to the following formula and analogs thereof: that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.
    Type: Grant
    Filed: December 29, 2022
    Date of Patent: April 2, 2024
    Assignee: Biomea Fusion, Inc.
    Inventors: David Sperandio, Xiaodong Wang, Thorsten A. Kirschberg, James T. Palmer, Thomas Butler, Solomon B. Ungashe, Neil Howard Squires, Nan-Horng Lin, Ravindra B. Upasani, Amna Trinity-Turjuman Adam, Yongli Su, Thu Phan
  • Publication number: 20240061864
    Abstract: A technology for retrieving data from a database. The technology includes receiving a search query specifying a target attribute and a target attribute value, accessing an index to determine one or more target files in which the target attribute value appears, the index including a plurality of attribute values, and for each of the attribute values, one or more files in which the attribute value appears, and retrieving data from the one or more target files.
    Type: Application
    Filed: November 2, 2023
    Publication date: February 22, 2024
    Inventors: Hossein Ahmadi, Guang Cheng, Yannis Sismanis, Huong Thi Thu Phan, Shiyu Xie, Leo Chen, Zewen Zhang, Jing Jing Long, Amir Hossein Hormati
  • Patent number: 11853326
    Abstract: A technology for retrieving data from a database. The technology includes receiving a search query specifying a target attribute and a target attribute value, accessing an index to determine one or more target files in which the target attribute value appears, the index including a plurality of attribute values, and for each of the attribute values, one or more files in which the attribute value appears, and retrieving data from the one or more target files.
    Type: Grant
    Filed: October 14, 2021
    Date of Patent: December 26, 2023
    Assignee: Google LLC
    Inventors: Hossein Ahmadi, Guang Cheng, Yannis Sismanis, Huong Thi Thu Phan, Shiyu Xie, Leo Chen, Zewen Zhang, Jing Jing Long, Amir Hossein Hormati
  • Publication number: 20230339867
    Abstract: Disclosed herein are heterocyclic compounds that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.
    Type: Application
    Filed: December 29, 2022
    Publication date: October 26, 2023
    Inventors: David Sperandio, Xiaodong Wang, Thorsten A. Kirschberg, James T. Palmer, Thomas Butler, Solomon B. Ungashe, Neil Howard Squires, Nan-Horng Lin, Ravindra B. Upasani, Amna Trinity-Turjuman Adam, Yongli Su, Thu Phan
  • Publication number: 20230117176
    Abstract: A technology for retrieving data from a database. The technology includes receiving a search query specifying a target attribute and a target attribute value, accessing an index to determine one or more target files in which the target attribute value appears, the index including a plurality of attribute values, and for each of the attribute values, one or more files in which the attribute value appears, and retrieving data from the one or more target files.
    Type: Application
    Filed: October 14, 2021
    Publication date: April 20, 2023
    Applicant: Google LLC
    Inventors: Hossein Ahmadi, Guang Cheng, Yannis Sismanis, Huong Thi Thu Phan, Shiyu Xie, Leo Chen, Zewen Zhang, Jing Jing Long, Amir Hossein Hormati
  • Publication number: 20210221854
    Abstract: This disclosure describes a system for generating influenza virus or influenza virus proteins, methods of making that system, and methods of using that system.
    Type: Application
    Filed: January 15, 2021
    Publication date: July 22, 2021
    Inventors: Wei-Shou Hu, Thu Phan, Christopher S. Stach, Ryan A. Langlois, Qian Ye
  • Patent number: 10385014
    Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: August 20, 2019
    Assignee: ARBOR PHARMACEUTICALS, LLC
    Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Thu Phan, Ge Peng
  • Publication number: 20180258032
    Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
    Type: Application
    Filed: March 7, 2018
    Publication date: September 13, 2018
    Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Thu Phan, Ge Peng
  • Patent number: 9944592
    Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: April 17, 2018
    Assignee: XENOPORT, INC.
    Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Thu Phan, Ge Peng
  • Publication number: 20170190657
    Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
    Type: Application
    Filed: December 22, 2016
    Publication date: July 6, 2017
    Applicant: XENOPORT, INC.
    Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Thu Phan, Ge Peng
  • Patent number: 9353057
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Grant
    Filed: January 15, 2013
    Date of Patent: May 31, 2016
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat
  • Patent number: 8378137
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: February 19, 2013
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat
  • Patent number: 8344028
    Abstract: Gamma-amino-butyric acid derivatives that are GABAB receptor ligands, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives and pharmaceutical compositions thereof for treating diseases are disclosed.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: January 1, 2013
    Assignee: XenoPort, Inc.
    Inventors: Feng Xu, Mark A. Gallop, Ge Peng, Thu Phan, Usha Dilip, David J. Wustrow
  • Publication number: 20120035139
    Abstract: Gamma-amino-butyric acid derivatives that are GABAB receptor ligands, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives and pharmaceutical compositions thereof for treating diseases are disclosed.
    Type: Application
    Filed: April 16, 2010
    Publication date: February 9, 2012
    Inventors: Feng Xu, Mark A. Gallop, Ge Peng, Thu Phan, Usha Dilip, David J. Wustrow
  • Publication number: 20120010425
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Application
    Filed: August 11, 2011
    Publication date: January 12, 2012
    Applicant: XENOPORT, INC.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat
  • Patent number: 8003809
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: August 23, 2011
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria J. Ludwikow, Ge Peng, Seema Bhat