Abstract: Compounds, such as compounds having Formula (I): wherein each variable is as described herein, that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Methods and systems for compact presentation of automatically summarized information according to rule-based graphically represented information. One of the methods includes obtaining, via a user accessible user interface, a request for uploaded textual information to be analyzed. Ontology information is accessed based on an indicated type associated with the textual information, and ontology information for the type. The ontology information specifies nodes, with the nodes causing the server system to extract values for textual expressions defined by the nodes, and relational information between the nodes, with the relational information indicating links between textual expressions. The textual information is parsed based on the ontology information. The parsing causes traversal of the nodes and extraction of values from associated textual expressions based on the textual information. Values are obtained based on the parsing, with the values being utilized as summary information.

Abstract: A material deposition unit includes a radiation unit designed to emit electromagnetic radiation in a directed manner onto a workpiece along a beam axis, and a powder discharge device that has multiple powder discharge units configured to discharge powder in a directed form onto the workpiece through powder-outlet openings. The material deposition unit further includes a powder division unit having multiple powder channels. A number of powder channels corresponds to a number of powder discharge units. The powder division unit is designed to distribute a central powder stream guided to a feed channel uniformly over the powder channels. Each respective powder channel is connected to a respective powder discharge unit by an exchangeable connecting element. At least one powder discharge unit has an exchangeable powder discharge element, which is elongate, has a first end and a second end, and is arranged at least partially within the corresponding powder discharge unit.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: A database system receives a query to be processed. The database system has resources. A user assigns the query to a tier of resource allocation priorities in a hierarchy of tiers. The tier has been designated as being automatically managed by the database system. The tier has a plurality of levels of priority for resource allocation (LPRAs). The database system decomposes the query into a first step and a set of subsequent steps. The first step has a beginning and each of the set of subsequent steps has a respective beginning. The database system assigns the first step to a first LPRA, wherein executing the query at the first LPRA is projected by the database system to satisfy a service level goal (SLG) within a on_schedule_range of the SLG.

Abstract: An ablation apparatus for creating a lesion in target tissue has a handle, an elongate shaft extending from the handle and a distal ablation portion. The distal ablation portion includes a cryogen flow manifold defining a plurality of fluid pathways between an insert body and a sleeve. Cryogen is circulated through the plurality of fluid pathways to create the lesion in the target tissue.

Abstract: Compounds that are inhibitors of at least one of ARG1 and ARG2, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by ARG1 and ARG2 are also described herein.

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Compounds that are inhibitors of at least one of the ARG1 and ARG2, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by ARG1 and ARG2 are also described herein.

Abstract: The present invention relates to purified and concentrated human milk oligosaccharide compositions and methods of making and using the same.

Abstract: The present invention relates to diacylglycerol acyltransferase genes and proteins, and methods of their use. In particular, the invention describes genes encoding proteins having increased diacylglycerol acetyltransferase activity compared to prior art proteins, specifically for transferring an acetyl group to a diacylglycerol substrate to form acetyl-Triacylglycerols (acetyl-TAGS), for example, a 3-acetyl-1,2-diacyl-sn-glycerol. The present invention encompasses both native and recombinant wild-type forms of the transferase, as well as mutants and variant forms. The present invention also relates to methods of using the diacylglycerol acyltransferase genes and proteins, including their expression in transgenic organisms at commercially viable levels, for increasing production of 3-acetyl-1,2-diacyl-sn-glycerols in plant oils and altering the composition of oils produced by microorganisms, such as yeast, by increasing acetyl-TAG production.

Abstract: Some embodiments include a method of detecting memes, as “key terms,” in a chatter aggregation in a social networking system. The method can include aggregating user-generated content objects within the social networking system into the chatter aggregation according to a set of filters. A meme analysis engine can define a target group within the chatter aggregation to compare against a background group. The meme analysis engine can extract key terms from textual content of the target group. The meme analysis engine can determine a relevancy rank of a term in the key terms based on an accounting of the term in the textual content of the target group and a linguistic relevance score of the term according to a linguistic model.

Abstract: Managing workflow on a plurality of installed application components that interact with a central hosted component is disclosed. A rule defined on the central hosted component is obtained. A new action item to be executed on an installed application component in the plurality of installed application components is generated at least in part by applying the obtained rule based at least in part on data provided by the installed application component and information that is managed by the central hosted component. The new action item to be executed by the installed application component is communicated. The new action item modifies a workflow on the installed application component without modifying application code on the installed application component.

Abstract: Methods and systems for compact presentation of automatically summarized information according to rule-based graphically represented information. One of the methods includes obtaining, via a user accessible user interface, a request for uploaded textual information to be analyzed. Ontology information is accessed based on an indicated type associated with the textual information, and ontology information for the type. The ontology information specifies nodes, with the nodes causing the server system to extract values for textual expressions defined by the nodes, and relational information between the nodes, with the relational information indicating links between textual expressions. The textual information is parsed based on the ontology information. The parsing causes traversal of the nodes and extraction of values from associated textual expressions based on the textual information. Values are obtained based on the parsing, with the values being utilized as summary information.

Abstract: A method of generating a synthetic content feed includes receiving a request to display a synthetic content feed for a class of users of a social networking system, identifying a first user and a second user based on profile data for the first user and second user in the social networking system, constructing a first post of synthetic content feed representative of a first post in the content feed of the first user, constructing a second post of synthetic content feed representative of a second post in the content feed of the second user, and providing the synthetic content feed for display.

Abstract: A database system includes a parser that is capable of parsing database queries containing user-defined data type (UDT) methods. The database query is transformed by the parser into a statement according to a specified format. In performing the transformation, redundant instantiations of UDTs and invocations of methods are removed. In one implementation, the redundant instantiations and invocations are removed by grouping and combining clauses containing UDT methods.