Abstract: Described herein, inter alia, are anti-cancer agents, anti-cancer pharmaceutical compositions, combinations of the agents and/or pharmaceutical compositions, and methods of using the same.

Abstract: The present invention is directed towards methods of expanding circulating tumor cell populations and methods of detecting circulating tumor cells in a sample.

Abstract: An electromigration-programmable semiconductor device may be programmed to increase the resistance or to decrease the resistance by selecting the amount of current passed through the electromigration-programmable semiconductor device. The electromigration-programmable semiconductor device comprises an anode, a cathode, and a link, each having a semiconductor portion and a metal semiconductor alloy portion. The metal semiconductor alloy portion of the link comprises two disjoined sub-portions with a gap therebetween. A low programming current fills the gap by electromigrating a small amount of metal semiconductor alloy from the cathode, A high programming current forms a large metal-semiconductor-alloy-deleted area in the cathode to increase the resistance. A tri-state programming is achieved by selecting the programming current level.

Abstract: Methods for fabricating functionalized substrate surfaces for use in preparing biomolecular microarrays, such that the substrate surfaces feature a uniform distribution of attachment functionality, functionalized substrates having such uniform distribution of attachment functionality, and microarrays prepared from such functionalized substrates. A plurality of linker groups are coupled to a substrate surface. A plurality of spacer groups including attachment sites for biological receptors are coupled to the linker groups. The linker groups can be coupled to the surface using a gas phase reaction. Spacers can include polyfunctional linear, branched or dendritic structures, such as polyethylene glycols and Starburst™ dendrimers. Attachment sites can be activated for the attachment of biological receptors.