Abstract: The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.

Abstract: The invention relates to a method for producing an amorphous three-dimensional architecture of the micro-lattice type formed of micro-beams connected together by nodes, which comprises: A) performing (100) a computer-implemented design step consisting, on the basis of a three-dimensional random arrangement (INIT) of non-deformable beads, in: a) producing (101) a three-dimensional random compact stack of said beads; b) for each bead, determining (102) the coordinates of the centre of the bead which correspond to those of a node; c) performing (103) a triangulation with said nodes, each triangle thus being defined with the nodes closest to one another, then associating two nodes connected by one side of a triangle to a micro-beam in order to define the micro-lattice; d) selecting (104) a sub-domain of the micro-lattice obtained in step c), not comprising the nodes located at the edge of the micro-lattice in order to define said amorphous three-dimensional architecture, the design step involving an average conne

Abstract: The invention relates to a method of manufacturing a two- or three-dimensional part having a composite architecture with at least two different micro-lattices connected to each other, comprising the following steps: performing (100) a computer-implemented design step comprising the following steps: A) defining (100A) a domain representing said part to be manufactured, then defining a first sub-domain for a first micro-lattice and a second sub-domain, complementary to the first sub-domain, to delimit a second micro-lattice different from the first micro-lattice; B) defining (100B), over the whole domain, the coordinates of the generating centres for the two micro-lattices, C) defining (100C) the first micro-lattice D) defining (100D) the second micro-lattice E) connecting (100E) the second micro-lattice to the first micro-lattice. the design step also defining a shape and associated transverse dimensions for each micro-beam, and then: manufacturing (200) the architecture designed in this way.

Abstract: Methods, systems, and devices for data management are described. A data management system (DMS) may support a communication service that may enable users to ask questions, troubleshoot problems, or initiate workflows. A user may initiate a communication session with the communication service by transmitting a query to the communication service. When a user initiates a chat session with the DMS, for example, via a query, the DMS may instantiate a handler of a handler class based on the use case (e.g., based on contextual information associated with the query). The DMS may use the handler to generate a use case specific prompt for a large language model (LLM) based on the query from the user. The DMS may provide the response from the LLM to the user. Different handler classes may also include use case specific function calls and parameters, which LLMs may use to trigger/initiate/suggest specific actions.

Abstract: An image forming apparatus includes a brake mechanism which supports an operation panel with respect to an apparatus body such that the operation panel can be stopped at an arbitrary angle. The brake mechanism includes a gear portion, a body-side gear, a button, and a bias member. The gear portion is formed about a rotation shaft in the operation panel. The body-side gear intermeshes with the gear portion and rotates about the rotation shaft. The button is movable in an axial direction of the rotation shaft. The bias member is arranged between the button and the body-side gear and biases the body-side gear along the axial direction. The brake mechanism is capable of reducing a braking force applied to a rotation of the body-side gear by moving the button along the axial direction in a direction in which it moves away from the body-side gear and reducing a bias force.

Abstract: A system and method are disclosed for autonomously performing a polytope analysis. The method further includes autonomously identifying input for use in the polytope analysis using natural language processing techniques, performing a polytope analysis using the identified input, generating response plans based on the performed polytope analysis, displaying the generated response plans, and executing at least one of the generated response plans. The method includes where the identified input comprises assumptions, goals, and levers for a polytope analysis. The method further includes providing a GUI that is configured to perform altering, adding and removing assumptions, goals and levers. The method further includes displaying assumption data associated with the polytope analysis, where the assumption data comprises type, priority, one dates, confidence, description and scope.

Abstract: A method of operation of a compute system includes: qualifying a patient image for analyzing a suspected skin condition; detecting a skin area in the patient image; segmenting the skin area into a segmented image including the suspected skin condition; cropping the segmented image to form a cropped image including the suspected skin condition at a center of the cropped image; analyzing the suspected skin condition to identify a skin disease result and a disease subclass from the cropped image; and assembling a disease identification display including the patient image, a skin disease indication, an image match score, and the disease subclass for displaying on a device.

Abstract: A method of operation of a compute system includes: generating a skin segmentation including a non-skin region and a skin prediction based on a patient image; generating a body part segmentation based on the patient image; generating a cropped image based on the skin segmentation and the body part segmentation with the cropped image includes the non-skin region based on the skin prediction; generating a eczema segmentation based on the cropped image and the skin prediction; generating intermediate scores for erythema, papulation, lichenification, and excoriation for the cropped image; and generating a full body EASI score based on the eczema segmentation and the intermediate scores for displaying on a device to assist in diagnosis.

Abstract: A method of operation of a compute system includes: generating a skin segmentation including a non-skin region and a skin prediction based on a patient image; generating a body part segmentation based on the patient image; generating a cropped image based on the skin segmentation and the body part segmentation with the cropped image includes the non-skin region based on the skin prediction; generating a lesion segmentation based on the cropped image and the skin prediction; generating intermediate scores for erythema, induration, desquamation for the cropped image; and generating a full body severity score based on the lesion segmentation and the intermediate scores for displaying on a device to assist in diagnosis.

Abstract: A method of operation of a compute system includes: verifying a patient image as an acceptable image; detecting a body part from the acceptable image; generating a skin segmentation for the body part including a non-skin region and a skin region based on the acceptable image; and generating a local Hidradenitis Suppurativa (HS) severity score based on the patient image for displaying on a device to assist in diagnosis.

Abstract: A method of operation of a compute system includes: detecting a skin area in a patient image; segmenting the skin area into a segmented image having an acne pimple at the center; generating a target pixel array from the segmented image includes separating a plurality of the acne pimples that are adjacent in the segmented image; identifying an acne characterization of the acne pimples including an area of each acne and an acne score; and assembling a user interface display from the acne characterization for displaying on a device.

Abstract: Methods, systems, and devices for data management are described. One or more requests to apply data observation to one or more data sources may be received via an interface. Whether snapshots are supported for the one or more data sources may be determined. A first, snapshot-supported data source may be stored at a first data storage as a snapshot and a representation of the second, snapshot-unsupported data source may be stored at a second data storage. First data may be extracted from the snapshot and second data may be extracted from the representation of the second data source such that a first data observation procedure may be applied to the first data and a second data observation procedure may be applied to the second data. Results of the data observation procedures may be reported via an interface.

Abstract: A wireless communication system may include an electronic device having an antenna element. The antenna element may convey radio-frequency signals greater than 10 GHz across a dielectric housing wall. A dielectric matching structure may be interposed between the antenna element and the dielectric housing wall. The wireless communication system may include external equipment having an antenna element communicatively coupled to the electronic device antenna element to convey firmware testing, debugging, restore, and/or other data via a near-field wireless communication link. The external equipment may be configured to receive the electronic device at an opening. A dielectric matching structure may be provided at the external equipment between the dielectric housing wall and the external equipment antenna element. The interior surface of the dielectric housing wall may have planar, convex, or concave portions.

Abstract: A method of operation of a compute system includes: verifying a patient image as an acceptable image; detecting a body part from the acceptable image; generating a skin segmentation for the body part including a non-skin region and a skin region based on the acceptable image; and generating a local Hidradenitis Suppurativa (HS) severity score based on the patient image for displaying on a device to assist in diagnosis.

Abstract: The present disclosure provides a medical device (100) for electrical stimulation. The medical device (100) includes electric circuitry configured to perform active charge compensation, said electric circuitry being connectable to at least one electrode arrangement (102) for electrical stimulation. The electric circuitry includes monitoring means configured to monitor at least one voltage associated with a stimulation network (108, 116); at least one variable resistive element configured to provide an voltage drop used in the active charge compensation: and adjustment means configured to dynamically adjust a resistance value of the at least one variable resistive element during the active charge compensation based on the at least one monitored voltage, wherein the adjustment means (202) is a finite state machine for neurostimulation.

Abstract: Described herein are robotic platforms and associated features that may have applicability in a wide variety of applications and industries, but that may have particular applicability in automotive testing and testing of vehicles having autonomous or semi-autonomous driving features. Robotic platforms may include a low-profile chassis, one or more rotational elements coupled to one or more drive motors and supported within the chassis, and a control system coupled to and controlling the drive motor(s). Also disclosed are suspension systems that may maintain the chassis of a robotic platform above the ground in use but that allows the chassis to ground out when subject to a pre-determined load, thereby spreading the load across the chassis.

Abstract: A method of operation of a compute system includes: generating a skin segmentation including a non-skin region and a skin prediction based on a patient image; generating a body part segmentation based on the patient image; generating a cropped image based on the skin segmentation and the body part segmentation with the cropped image includes the non-skin region based on the skin prediction; generating a eczema segmentation based on the cropped image and the skin prediction; generating intermediate scores for erythema, papulation, lichenification, and excoriation for the cropped image; and generating a full body EASI score based on the eczema segmentation and the intermediate scores for displaying on a device to assist in diagnosis.

Abstract: A method of operation of a compute system includes: generating a skin segmentation including a non-skin region and a skin prediction based on a patient image; generating a body part segmentation based on the patient image; generating a cropped image based on the skin segmentation and the body part segmentation with the cropped image includes the non-skin region based on the skin prediction; generating a lesion segmentation based on the cropped image and the skin prediction; generating intermediate scores for erythema, induration, desquamation for the cropped image; and generating a full body severity score based on the lesion segmentation and the intermediate scores for displaying on a device to assist in diagnosis.

Abstract: An electronic device may include baseband circuitry coupled to antennas over a communication path that includes signal paths on a first substrate, a second substrate, and a third substrate. The antennas may be disposed on the third substrate. A wireless connector may couple the paths on the third substrate to the paths on the second substrate. The wireless connector may include a first transceiver and first antenna on the third substrate and a second transceiver and second antenna on the second substrate. The wireless connector may include one or more dielectric layers disposed between the first antenna and the second antenna. The layers may form a smooth impedance transition between the first antenna and the second antenna. The layers may include one or two angled layers that redirect wireless signals between the first and second antennas to allow the first and second substrates to be offset within the device.

Abstract: Described herein are robotic platforms and associated features that may have applicability in a wide variety of applications and industries, but that may have particular applicability in automotive testing and testing of vehicles having autonomous or semi-autonomous driving features. Robotic platforms may include a low-profile chassis, one or more rotational elements coupled to one or more drive motors and supported within the chassis, and a control system coupled to and controlling the drive motor(s). Also disclosed are suspension systems that may maintain the chassis of a robotic platform above the ground in use but that allows the chassis to ground out when subject to a pre-determined load, thereby spreading the load across the chassis.