Abstract: A system including one or more processors and one or more non-transitory computer-readable media storing computing instructions that, when executed on the one or more processors perform certain functions: obtaining an input comprising a sequence of service locations; iterating through pairs of consecutive service locations of the service locations to determine when a port for the first service location is different from the port for the second service location; adding the port for the first service location and the port for the second service location; and iterating through hours of service (HOS) states of the offshore route; determining whether to add one or more additional HOS states in the offshore route; and resetting a cumulative drive time to zero for each offshore port-to-port service. Other embodiments are disclosed.

Abstract: A system including one or more processors and one or more non-transitory computer-readable media storing computing instructions, that when executed on the one or more processors, cause the one or more processors, to perform: obtaining a first load plan, wherein the first load plan comprises a set of stacks assigned to floor spots of a trailer; determining that at least one of (a) there is an empty floor spot in the first load plan for the trailer or (b) the first load plan is infeasible; determining a target number of stacks for an updated load plan; iterating, via simulated annealing, through modifications to the updated load plan; terminating the iterating when a predetermined termination criteria is satisfied; and outputting the updated load plan. Other embodiments are disclosed.

Abstract: Systems and methods including one or more processors and one or more non-transitory computer readable media storing computing instructions that, when executed on the one or more processors, cause the one or more processors to perform: receiving workload information corresponding to a workload, driver information corresponding to drivers, and one or more constraints; building a coordinate system based on the workload information, the driver information and the one or more constraints; analyzing the coordinate system to determine a respective efficiency metric for each driver of the drivers for the workload; identifying a driver of the drivers in which the respective efficiency metric for the driver satisfies an efficiency metric threshold; and assigning the workload to the driver to reduce driver workload waste. Other embodiments are disclosed.

Abstract: A system comprising one or more processors and one or more non-transitory computer-readable media storing computing instructions, that when executed on the one or more processors, cause the one or more processors, to perform functions comprising: receiving, by an application programing interface (API), a change request for a route plan, wherein the change request is subject to a scenario specification and a load feasibility specification; determining an updated route plan based on whether the change request for the route plan is a feasible route based on the scenario specification and the load feasibility specification, and the route stop time is the route start time is flexible; and outputting the updated route plan and, when the route stop time is flexible, outputting the route start time. Other embodiments are disclosed.

Abstract: A system comprising one or more processors; and one or more non-transitory computer-readable media storing computing instructions, that when executed on the one or more processors, cause the one or more processors to perform functions comprising: obtaining a route plan for outbound transport from a distribution center; processing multiple threads in parallel to obtain multiple improvements to the route plan, where each of the multiple threads customizes the route plan using one or more different parameters; selecting a lowest cost route solution from the multiple improvements to the route plan; and using the lowest cost route solution for the outbound transport from the distribution center. Other embodiments are disclosed.

Abstract: A method including obtaining an optimization request at a coordinating engine. The method also can include triggering engines to process the optimization request. At least one of the engines divides the optimization request into subproblems. At least a portion of the engines solve the subproblems. Respective instances of at least one of the engines are triggered to handle respective ones of the subproblems. Each of the engines provides a dynamic algorithmic flow using modularized algorithmic solvers. The dynamic algorithmic flow is adjusted based on a respective input to each of the engines. The method additionally can include outputting, from the coordinating engine, one or more results in response to the optimization request, based on results for the subproblems generated by the engines. Other embodiments are described.

Abstract: A methodology using an interwell connectivity model for hydrocarbon management is disclosed. The interwell connectivity model may include interwell connectivity metrics indicative of fluid interconnectivity amongst pairs of wells and may be used as predictive or prescriptive for enhanced oil recovery (EOR). As predictive, the interwell connectivity model may be used to determine an effect of gas injection into the reservoir on one or more aspects of EOR, such as reservoir pressure or production rates. As prescriptive, the interwell connectivity model may be used to improve or optimize various stages of EOR, such as during drilling or construction of the extraction site, during primary depletion, or during one or more huff-and-puff cycles.

Abstract: Provided are platinum(IV) compounds of Formula I or pharmaceutically acceptable salts thereof. Also provided are compositions including such compounds as well as methods of using the same.

Abstract: The present technology is directed to TLR7 and TLR8 agonist compounds, compositions, and methods of using the same for the treatment of cancers and as vaccine adjuvants.

Abstract: The present invention relates to novel therapeutic nanoparticles. In particular, the present invention is directed to nanoparticles associated (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) with angiogenesis-activating-agents, methods of synthesizing the same, devices or compositions comprising such nanoparticles, as well as systems and methods utilizing the nanoparticles (e.g., in therapeutic settings for enhancing and/or activating angiogenesis at targeted tissue region).

Abstract: The present invention relates to novel therapeutic nanoparticles. In particular, the present invention is directed to nanoparticles associated (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) with angiogenesis-activating-agents, methods of synthesizing the same, devices or compositions comprising such nanoparticles, as well as systems and methods utilizing the nanoparticles (e.g., in therapeutic settings for enhancing and/or activating angiogenesis at targeted tissue region).

Abstract: Provided are platinum(IV) compounds of Formula I or pharmaceutically acceptable salts thereof. Also provided are compositions including such compounds as well as methods of using the same.

Abstract: One aspect of the present invention is directed to conjugates that comprise a linear polymer carrier, a linker and one or more drugs or imaging agents, as well as pharmaceutical compositions that include such conjugates. The drug may be a platinum-containing drug with a linker comprised of a modified amino acid. The conjugate may alternatively include a metal complexing ligand with a metal used for imaging or chemotherapeutic purposes. Another aspect of the invention is directed to formulations and processes for lyophilization of hyaluronan conjugates. Another aspect of the invention is directed to methods for treating and/or inhibiting cancer utilizing the conjugates and compositions described herein.

Abstract: The present invention relates to novel therapeutic nanoparticles. In particular, the present invention is directed to nanoparticles associated (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) with angiogenesis-activating-agents, methods of synthesizing the same, devices or compositions comprising such nanoparticles, as well as systems and methods utilizing the nanoparticles (e.g., in therapeutic settings for enhancing and/or activating angiogenesis at targeted tissue region).

Abstract: The present invention is directed to drug conjugates of mTOR inhibitors comprising an mTOR inhibitor, such as rapamycin, conjugated to hyaluronic acid by a linker comprising an ester, carbonate, or carbamate. The present invention is also directed to pharmaceutical compositions comprising the drug conjugates, and methods of making and using the drug conjugates and the pharmaceutical compositions.

Abstract: A multi-arm, star-shaped polymer composition can be configured for drug delivery and imaging applications in vivo. The star polymer architecture can be synthesized using living radical polymerization techniques, including reversible addition-fragmentation chain transfer and macromolecular design via the interchange of xanthates with a broad range of reaction conditions and functional groups. The star-shaped polymeric carriers can be tailored for preferential delivery of chemotherapeutics into the tumor-draining lymphatics via subcutaneous, peritumoral or intratumoral injections. The carriers can be loaded with the chemotherapeutic agents from about 10% to about 25% w/w. In addition, the carriers can be loaded with imaging agents from about 5% to about 10% w/w. The molecular weights of the polymeric carriers can be about 40 kDa to about 130 kDa. The chemotherapeutics can be cisplatin, geldanamycin or nitric oxide-donating prodrugs. The imaging agent can be a near-infrared dye, such as IR820.