Abstract: A method for regulating the condition of mammalian skin by the steps of applying a first personal care composition to an area of skin where regulation is desired. The first personal care composition contains a gel composition. In another step energy is delivered to the dermis to heat collagen in the dermis such that the heated collagen in the dermis heats the epidermis and stratum corneum until the stratum corneum reaches an external temperature of from about 37° C. to about 48° C. The energy delivery to the dermis is then controlled to maintain the temperature of the stratum corneum in the range of from about 37° C. to about 48° C.

Abstract: A gene panel comprising genes regulated in mammalian skin in response to generation of a radio frequency current in a tissue volume of the mammalian skin sufficient to heat the tissue volume to a treatment temperature, wherein at least one gene is selected from Table 1 or Table 2 and at least one gene is selected from Table 3. Further there is a method for providing a benefit to mammalian skin, the benefit comprising inducing collagen formation and/or dermal remodeling in a dermal layer of the mammalian skin in the absence of a skin-damaging inflammatory cytokine response, the method comprising generating a radio frequency current in a tissue volume of the mammalian skin for a treatment cycle sufficient to heat the tissue volume to a treatment temperature while avoiding an upregulation in expression of genes listed in Table 3.