Patents by Inventor Tia Marie Ditommaso

Tia Marie Ditommaso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene editing systems comprising an RNA guide targeting lactate dehydrogenase a (LDHA) and uses thereof
    Patent number: 11939607
    Abstract: Provided herein are gene editing systems and/or compositions comprising RNA guides targeting LDHA for use in genetic editing of the LDHA gene. Also provide herein are methods of using the gene editing system for introducing edits to the LDHA gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.
    Type: Grant
    Filed: November 4, 2022
    Date of Patent: March 26, 2024
    Assignee: ARBOR BIOTECHNOLOGIES, INC.
    Inventors: Quinton Norman Wessells, Jeffrey Raymond Haswell, Tia Marie Ditommaso, Noah Michael Jakimo, Sejuti Sengupta
  • Compositions comprising a variant Cas12i4 polypeptide and uses thereof
    Patent number: 11866746
    Abstract: The present invention relates to variant Cas12i4 polypeptides, methods of producing the variant Cas12i4 polypeptides, processes for characterizing the variant Cas12i4 polypeptides, cells comprising the variant Cas12i4 polypeptides, and methods of using the variant Cas12i4 polypeptides. The invention further relates to complexes comprising a variant Cas12i4 polypeptide and an RNA guide, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.
    Type: Grant
    Filed: December 30, 2022
    Date of Patent: January 9, 2024
    Assignee: ARBOR BIOTECHNOLOGIES, INC.
    Inventors: Shaorong Chong, Wei-Cheng Lu, Brendan Jay Hilbert, Quinton Norman Wessells, Tia Marie Ditommaso, Anthony James Garrity
  • COMPOSITIONS COMPRISING AN RNA GUIDE TARGETING BCL11A AND USES THEREOF
    Publication number: 20230416732
    Abstract: The present invention relates to compositions comprising RNA guides targeting BCL11A, processes for characterizing the compositions, cells comprising the compositions, and methods of using the compositions.
    Type: Application
    Filed: October 29, 2021
    Publication date: December 28, 2023
    Inventors: Quinton Norman Wessells, Jeffrey Raymond Haswell, Tia Marie Ditommaso, Noah Michael Jakimo
  • COMPOSITIONS COMPRISING AN RNA GUIDE TARGETING PDCD1 AND USES THEREOF
    Publication number: 20230407343
    Abstract: The present invention relates to compositions comprising RNA guides targeting PDCD1, processes for characterizing the compositions, cells comprising the compositions, and methods of using the compositions.
    Type: Application
    Filed: October 29, 2021
    Publication date: December 21, 2023
    Inventors: Quinton Norman Wessells, Jeffrey Raymond Haswell, Tia Marie Ditommaso, Noah Michael Jakimo
  • COMPOSITIONS COMPRISING AN RNA GUIDE TARGETING B2M AND USES THEREOF
    Publication number: 20230399639
    Abstract: The present invention relates to compositions comprising RNA guides targeting B2M, processes for characterizing the compositions, cells comprising the compositions, and methods of using the compositions.
    Type: Application
    Filed: October 29, 2021
    Publication date: December 14, 2023
    Applicant: Arbor Biotechnologies, Inc.
    Inventors: Quinton Norman Wessells, Jeffrey Raymond Haswell, Tia Marie DiTommaso, Noah Michael Jakimo
  • Gene editing systems comprising an RNA guide targeting hydroxyacid oxidase 1 (HAO1) and uses thereof
    Patent number: 11821012
    Abstract: Provided herein are gene editing systems and/or compositions comprising RNA guides targeting HAO1 for use in genetic editing of the HAO1 gene. Also provide herein are methods of using the gene editing system for introducing edits to the HAO1 gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.
    Type: Grant
    Filed: November 4, 2022
    Date of Patent: November 21, 2023
    Assignee: Arbor Biotechnologies, Inc.
    Inventors: Quinton Norman Wessells, Jeffrey Raymond Haswell, Tia Marie Ditommaso, Noah Michael Jakimo, Sejuti Sengupta
  • COMPOSITIONS COMPRISING A CAS12I2 VARIANT POLYPEPTIDE AND USES THEREOF
    Publication number: 20230332119
    Abstract: The present invention relates to variant Cas12i2 polypeptides, methods of producing the variant Cas12i2 polypeptides, processes for characterizing the variant Cas12i2 polypeptides, cells comprising the variant Cas12i2 polypeptides, and methods of using the variant Cas12i2 polypeptides. The invention further relates to complexes comprising the variant Cas12i2 polypeptides, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.
    Type: Application
    Filed: March 31, 2021
    Publication date: October 19, 2023
    Inventors: Shaorong CHONG, Brendan Jay HILBERT, Quinton Norman WESSELLS, Noah Michael JAKIMO, Roy ZIBLAT, Jason Michael CARTE, Tia Marie DITOMMASO, Jeffrey Raymond HASWELL, Anthony James GARRITY, Colin Alexander MCGAW, David A. SCOTT, Derek Michael CERCHIONE
  • COMPOSITIONS COMPRISING A VARIANT CAS12I4 POLYPEPTIDE AND USES THEREOF
    Publication number: 20230295589
    Abstract: The present invention relates to variant Cas12i4 polypeptides, methods of producing the variant Cas12i4 polypeptides, processes for characterizing the variant Cas12i4 polypeptides, cells comprising the variant Cas12i4 polypeptides, and methods of using the variant Cas12i4 polypeptides. The invention further relates to complexes comprising a variant Cas12i4 polypeptide and an RNA guide, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.
    Type: Application
    Filed: December 30, 2022
    Publication date: September 21, 2023
    Inventors: Shaorong CHONG, Wei-Cheng LU, Brendan Jay HILBERT, Quinton Norman WESSELLS, Tia Marie DITOMMASO, Anthony James GARRITY
  • CELLS MODIFIED BY A CAS12I POLYPEPTIDE
    Publication number: 20230235305
    Abstract: The present disclosure relates to cells modified by a Cas12i polypeptide, methods of modifying the cells, processes for characterizing the modified cells, compositions and formulations comprising the modified cells, and uses of the compositions and formulations comprising the modified cells.
    Type: Application
    Filed: June 16, 2021
    Publication date: July 27, 2023
    Inventors: Noah Michael JAKIMO, Quinton Norman WESSELLS, Tia Marie DITOMMASO, Jeffrey Raymond HASWELL, Anthony James GARRITY, Jason Michael CARTE, Colin Alexander MCGAW, Shaorong CHONG, David A. SCOTT
  • GENE EDITING SYSTEMS COMPRISING AN RNA GUIDE TARGETING HYDROXYACID OXIDASE 1 (HAO1) AND USES THEREOF
    Publication number: 20230212541
    Abstract: Provided herein are gene editing systems and/or compositions comprising RNA guides targeting HAO1 for use in genetic editing of the HAO1 gene. Also provide herein are methods of using the gene editing system for introducing edits to the HAO1 gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.
    Type: Application
    Filed: November 4, 2022
    Publication date: July 6, 2023
    Inventors: Quinton Norman WESSELLS, Jeffrey Raymond HASWELL, Tia Marie DITOMMASO, Noah Michael JAKIMO, Sejuti SENGUPTA
  • GENE EDITING SYSTEMS COMPRISING AN RNA GUIDE TARGETING LACTATE DEHYDROGENASE A (LDHA) AND USES THEREOF
    Publication number: 20230212540
    Abstract: Provided herein are gene editing systems and/or compositions comprising RNA guides targeting LDHA for use in genetic editing of the LDHA gene. Also provide herein are methods of using the gene editing system for introducing edits to the LDHA gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.
    Type: Application
    Filed: November 4, 2022
    Publication date: July 6, 2023
    Inventors: Quinton Norman WESSELLS, Jeffrey Raymond HASWELL, Tia Marie DITOMMASO, Noah Michael JAKIMO, Sejuti SENGUPTA
  • GENE EDITING SYSTEMS COMPRISING AN RNA GUIDE TARGETING STATHMIN 2 (STMN2) AND USES THEREOF
    Publication number: 20230203539
    Abstract: A system for genetic editing of a stathmin 2 (STMN2) gene, comprising (i) a Cas12i2 polypeptide or a first nucleic acid encoding the Cas12i2 polypeptide, and (ii) an RNA guide or a second nucleic acid encoding the RNA guide, wherein the RNA guide comprises a spacer sequence specific to a target sequence within an STMN2 gene. Also provided herein are methods for editing a STMN2 gene using the gene editing system disclosed herein and/or for treating diseases associated with the STMN2 gene.
    Type: Application
    Filed: August 11, 2022
    Publication date: June 29, 2023
    Inventors: Tia Marie DITOMMASO, Anthony James GARRITY, Noah Michael JAKIMO, Quinton Norman WESSELLS
  • COMPOSITIONS COMPRISING A CAS12I2 POLYPEPTIDE AND USES THEREOF
    Publication number: 20230193243
    Abstract: The present invention relates to compositions comprising a Cas12i2 polypeptide and an RNA guide, processes for characterizing the compositions, cells comprising the compositions, and methods of using the compositions.
    Type: Application
    Filed: May 28, 2021
    Publication date: June 22, 2023
    Inventors: David A. SCOTT, Kerri-Lynn SHEAHAN, Tia Marie DITOMMASO, Quinton Norman WESSELLS, Noah Michael JAKIMO
  • GENE EDITING SYSTEMS COMPRISING AN RNA GUIDE TARGETING HYDROXYACID OXIDASE 1 (HAO1) AND USES THEREOF
    Publication number: 20230032141
    Abstract: Provided herein are gene editing systems and/or compositions comprising RNA guides targeting HAO1 for use in genetic editing of the HAO1 gene. Also provide herein are methods of using the gene editing system for introducing edits to the HAO1 gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.
    Type: Application
    Filed: June 3, 2022
    Publication date: February 2, 2023
    Inventors: Quinton Norman WESSELLS, Jeffrey Raymond HASWELL, Tia Marie DITOMMASO, Noah Michael JAKIMO, Sejuti SENGUPTA
  • GENE EDITING SYSTEMS COMPRISING AN RNA GUIDE TARGETING LACTATE DEHYDROGENASE A (LDHA) AND USES THEREOF
    Publication number: 20230034581
    Abstract: Provided herein are gene editing systems and/or compositions comprising RNA guides targeting LDHA for use in genetic editing of the LDHA gene. Also provide herein are methods of using the gene editing system for introducing edits to the LDHA gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.
    Type: Application
    Filed: June 3, 2022
    Publication date: February 2, 2023
    Inventors: Quinton Norman WESSELLS, Jeffrey Raymond HASWELL, Tia Marie DITOMMASO, Noah Michael JAKIMO, Sejuti SENGUPTA
  • GENE EDITING SYSTEMS COMPRISING AN RNA GUIDE TARGETING TRANSTHYRETIN (TTR) AND USES THEREOF
    Publication number: 20220396782
    Abstract: A system for genetic editing of a transthyretin (TTR) gene, comprising (i) a Cas12i2 polypeptide or a first nucleic acid encoding the Cas12i2 polypeptide, and (ii) an RNA guide or a second nucleic acid encoding the RNA guide, wherein the RNA guide comprises a spacer sequence specific to a target sequence within an TTR gene. Also provided herein are methods for editing a TTR gene using the gene editing system disclosed herein and/or for treating diseases associated with the TTR gene.
    Type: Application
    Filed: June 3, 2022
    Publication date: December 15, 2022
    Inventors: Quinton Norman WESSELLS, Jeffrey Raymond HASWELL, Tia Marie DITOMMASO, Noah Michael JAKIMO, Sejuti SENGUPTA
  • NOVEL CRISPR DNA TARGETING ENZYMES AND SYSTEMS
    Publication number: 20220372456
    Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.
    Type: Application
    Filed: July 10, 2020
    Publication date: November 24, 2022
    Inventors: David A. Scott, David R. Cheng, Winston X. Yan, Tia Marie Ditommaso