Patents by Inventor Tiago Fleming Outeiro
Tiago Fleming Outeiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Antibody Molecules and Peptide Delivery Systems for Use in Alzheimer's Disease and Related Disorders
Publication number: 20210355200Abstract: The present invention relates to antibody molecules and peptide delivery systems for use in the treatment and management of Alzheimer's disease and related disorders. In particular, the antibody molecules preferentially bind oligomeric forms of beta-amyloid peptide, in single domain format, and the peptide delivery systems facilitate specific transport of such antibody molecules, as well as other cargo molecules, across the blood-brain barrier. The invention also relates to constructs of the antibody molecules and the delivery peptides, as well as pharmaceutical compositions comprising effective amounts of the antibody molecules, delivery peptides, and/or their constructs, including humanized versions of the antibody molecules and constructs.Type: ApplicationFiled: April 30, 2020Publication date: November 18, 2021Inventors: Sofia Volker Côrte-Real, Vera Luísa Santos Neves, Pedro Manuel Correia Canhão, Tiago Fleming Outeiro, Miguel Augusto Rico Botas Castanho, Frederico Nuno Castanheira Aires Da Silva, Soraia Rafaela Santiago De Oliveira -
Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders
Patent number: 10654917Abstract: The present invention relates to antibody molecules and peptide delivery systems for use in the treatment and management of Alzheimer's disease and related disorders. In particular, the antibody molecules preferentially bind oligomeric forms of beta-amyloid peptide, in single domain format, and the peptide delivery systems facilitate specific transport of such antibody molecules, as well as other cargo molecules, across the blood-brain barrier. The invention also relates to constructs of the antibody molecules and the delivery peptides, as well as pharmaceutical compositions comprising effective amounts of the antibody molecules, delivery peptides, and/or their constructs, including humanized versions of the antibody molecules and constructs.Type: GrantFiled: January 29, 2016Date of Patent: May 19, 2020Assignee: TECHNOPHAGE, INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA, SAInventors: Sofia Volker Côrte-Real, Vera Luísa Santos Neves, Pedro Manuel Correia Canhão, Tiago Fleming Outeiro, Miguel Augusto Rico Botas Castanho, Frederico Nuno Castanheira Aires Da Silva, Soraia Rafaela Santiago De Oliveira -
Antibody Molecules and Peptide Delivery Systems for Use in Alzheimer's Disease and Related Disorders
Publication number: 20180009883Abstract: The present invention relates to antibody molecules and peptide delivery systems for use in the treatment and management of Alzheimer's disease and related disorders. In particular, the antibody molecules preferentially bind oligomeric forms of beta-amyloid peptide, in single domain format, and the peptide delivery systems facilitate specific transport of such antibody molecules, as well as other cargo molecules, across the blood-brain barrier. The invention also relates to constructs of the antibody molecules and the delivery peptides, as well as pharmaceutical compositions comprising effective amounts of the antibody molecules, delivery peptides, and/or their constructs, including humanized versions of the antibody molecules and constructs.Type: ApplicationFiled: January 29, 2016Publication date: January 11, 2018Inventors: Sofia VOLKER CÔRTE-REAL, Vera Luísa SANTOS NEVES, Pedro Manuel CORREIA CANHÃO, Tiago FLEMING OUTEIRO, Miguel Augusto RICO BOTAS CASTANHO, Frederico Nuno CASTANHEIRA AIRES DA SILVA, Soraia Rafaela SANTIAGO DE OLIVEIRA -
Publication number: 20170306386Abstract: Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.Type: ApplicationFiled: November 8, 2016Publication date: October 26, 2017Applicant: The University of ChicagoInventors: Susan Lindquist, Sylvia Krobitsch, Tiago Fleming Outeiro
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Patent number: 9518284Abstract: Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.Type: GrantFiled: December 13, 2013Date of Patent: December 13, 2016Assignee: The University of ChicagoInventors: Susan Lindquist, Sylvia Krobitsch, Tiago Fleming Outeiro
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Publication number: 20140273074Abstract: Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.Type: ApplicationFiled: December 13, 2013Publication date: September 18, 2014Applicant: THE UNIVERSITY OF CHICAGOInventors: Susan Lindquist, Sylvia Krobitsch, Tiago Fleming Outeiro
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Publication number: 20130005608Abstract: Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.Type: ApplicationFiled: May 2, 2012Publication date: January 3, 2013Applicant: THE UNIVERSITY OF CHICAGOInventors: Susan Lindquist, Sylvia Krobitsch, Tiago Fleming Outeiro
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Publication number: 20110300533Abstract: Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.Type: ApplicationFiled: April 20, 2011Publication date: December 8, 2011Inventors: Susan Lindquist, Sylvia Krobitsch, Tiago Fleming Outeiro
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Patent number: 8039209Abstract: Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.Type: GrantFiled: February 27, 2006Date of Patent: October 18, 2011Assignee: The University of ChicagoInventors: Susan Lindquist, Sylvia Krobitsch, Tiago Fleming Outeiro
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Patent number: 7045290Abstract: Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.Type: GrantFiled: February 15, 2002Date of Patent: May 16, 2006Assignee: The University of ChicagoInventors: Susan Lindquist, Sylvia Krobitsch, Tiago Fleming Outeiro
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Publication number: 20030073610Abstract: Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.Type: ApplicationFiled: February 15, 2002Publication date: April 17, 2003Applicant: The University of ChicagoInventors: Susan Lindquist, Sylvia Krobitsch, Tiago Fleming Outeiro