Patents by Inventor Tiago Outeiro

Tiago Outeiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of identifying agents that diminish cellular toxicity associated with an ?-synuclein polypeptide of parkinson's disease in yeast
    Patent number: 8735072
    Abstract: Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: May 27, 2014
    Assignees: Whitehead Institute for Biomedical Research, University of Washington
    Inventors: Paul J. Muchowski, Susan L. Lindquist, Tiago Outeiro
  • COMPOSITIONS AND METHODS FOR TREATMENT OF PROTEIN MISFOLDING DISEASES
    Publication number: 20130237451
    Abstract: Disclosed are compounds and conditions that either suppress or enhance toxicity in yeast cells expressing alpha synuclein or huntingtin. These compounds and conditions can be used in the development of compositions that suppress toxicity, fibril formation, and/or diseases mediated at least in part by alpha synuclein or huntingtin.
    Type: Application
    Filed: November 26, 2012
    Publication date: September 12, 2013
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Susan L. Lindquist, Tiago Outeiro
  • Compounds, compositions and methods of inhibiting alpha-synuclein toxicity
    Patent number: 8440705
    Abstract: Compounds and compositions are provided for treatment or amelioration of one or more symptoms of ?-synuclein toxicity, ?-synuclein mediated diseases or diseases in which ?-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihydropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: May 14, 2013
    Assignees: Whitehead Institute for Biomedical Research, FoldRx Pharmaceuticals, Inc.
    Inventors: Susan L. Lindquist, Tiago Outeiro, Richard Labaudinière
  • METHODS OF IDENTIFYING LEAD COMPOUNDS THAT MODULATE TOXICITY OF NEUROTOXIC POLYPEPTIDES
    Publication number: 20130084596
    Abstract: Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
    Type: Application
    Filed: March 13, 2012
    Publication date: April 4, 2013
    Applicants: UNIVERSITY OF WASHINGTON, WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Paul J. Muchowski, Susan L. Lindquist, Tiago Outeiro
  • Methods of identifying agents that diminish cellular toxicity associated with an ?-synuclein polypeptide of Parkinson's disease in yeast
    Patent number: 8133679
    Abstract: Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
    Type: Grant
    Filed: November 17, 2008
    Date of Patent: March 13, 2012
    Assignees: Whitehead Institute for Biomedical Research, University of Washington
    Inventors: Paul J. Muchowski, Susan L. Lindquist, Tiago Outeiro
  • YEAST ECTOPICALLY EXPRESSING ABNORMALLY PROCESSED PROTEINS AND USES THEREFOR
    Publication number: 20120003243
    Abstract: Disclosed are yeast ectopically expressing abnormally processed proteins and methods of screening to identify compounds that modulate the function of such abnormally processed proteins in yeast. Compounds identified by such screens can be used to treat or prevent diseases associated with abnormally processed proteins or protein misfolding. Such diseases include Parkinson's Disease, Parkinson's Disease with accompanying dementia, Lewy body dementia, Alzheimer's disease with Parkinsonism, and multiple system atrophy.
    Type: Application
    Filed: May 17, 2010
    Publication date: January 5, 2012
    Applicant: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Susan L. Lindquist, Tiago Outeiro
  • INHIBITION OF ALPHA-SYNUCLEIN TOXICITY
    Publication number: 20100273776
    Abstract: Compounds and compositions are provided for treatment or amelioration of one or more symptoms of ?-synuclein toxicity, ?-synuclein mediated diseases or diseases in which ?-synuclein fibrils are a symptom or cause of the disease.
    Type: Application
    Filed: March 29, 2007
    Publication date: October 28, 2010
    Applicants: FOLDRx PHARMACEUTICALS, INC, WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Susan L. Lindquist, Tiago Outeiro, Richard Labaudinière, James Fleming, Christine Ellen Bulawa, Charlotte Weigel, Feng Liang, Sandeep Gupta, Amy Ripka
  • METHODS OF IDENTIFYING LEAD COMPOUNDS THAT MODULATE TOXICITY OF NEUROTOXIC POLYPEPTIDES
    Publication number: 20090068111
    Abstract: Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
    Type: Application
    Filed: November 17, 2008
    Publication date: March 12, 2009
    Applicants: UNIVERSITY OF WASHINGTON, WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Paul J. Muchowski, Susan L. Lindquist, Tiago Outeiro
  • Methods of identifying agents that diminish cellular toxicity associated with an ?-synuclein polypeptide of Parkinson's disease in yeast
    Patent number: 7452670
    Abstract: Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: November 18, 2008
    Assignees: University of Washington, Whitehead Institute for Biomedical Research
    Inventors: Paul J. Muchowski, Susan L. Lindquist, Tiago Outeiro
  • Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity
    Publication number: 20080261953
    Abstract: Compounds and compositions are provided for treatment or amelioration of one or more symptoms of ?-synuclein toxicity, ?-synuclein mediated diseases or diseases in which ?-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihy-dropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.
    Type: Application
    Filed: September 16, 2005
    Publication date: October 23, 2008
    Applicants: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, FOLDRX PHARMACEUTICALS, INC.
    Inventors: Susan L. Lindquist, Tiago Outeiro, Richard Labaudiniere
  • Compositions and Methods for Treatment of Protein Misfolding Diseases
    Publication number: 20080249129
    Abstract: Disclosed are compounds and conditions that either suppress or enhance toxicity in yeast cells expressing alpha synuclein or huntingtin. These compounds and conditions can be used in the development of compositions that suppress toxicity, fibril formation, and/or diseases mediated at least in part by alpha synuclein or huntingtin.
    Type: Application
    Filed: April 4, 2005
    Publication date: October 9, 2008
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Susan L. Lindquist, Tiago Outeiro
  • Yeast screens for treatment of human disease
    Publication number: 20060147902
    Abstract: Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.
    Type: Application
    Filed: February 27, 2006
    Publication date: July 6, 2006
    Inventors: Susan Lindquist, Sylvia Krobitsch, Tiago Outeiro
  • Yeast screens for treatment of human disease
    Publication number: 20060141449
    Abstract: Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.
    Type: Application
    Filed: February 27, 2006
    Publication date: June 29, 2006
    Inventors: Susan Lindquist, Sylvia Krobitsch, Tiago Outeiro
  • Methods of identifying lead compounds that modulate toxicity of neurotoxic polypeptides
    Publication number: 20050255450
    Abstract: Methods of screening candidate agents to identify lead compounds for the development of therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.
    Type: Application
    Filed: December 3, 2004
    Publication date: November 17, 2005
    Applicants: University of Washington, Whitehead Institute for Biomedical Research
    Inventors: Paul Muchowski, Susan Lindquist, Tiago Outeiro
  • Yeast ectopically expressing abnormally processed proteins and uses therefor
    Publication number: 20050064548
    Abstract: Disclosed are yeast ectopically expressing abnormally processed proteins and methods of screening to identify compounds that modulate the function of such abnormally processed proteins in yeast. Compounds identified by such screens can be used to treat or prevent diseases associated with abnormally processed proteins or protein misfolding. Such diseases include Parkinson's Disease, Parkinson's Disease with accompanying dementia, Lewy body dementia, Alzheimer's disease with Parkinsonism, and multiple system atrophy.
    Type: Application
    Filed: April 16, 2004
    Publication date: March 24, 2005
    Inventors: Susan Lindquist, Tiago Outeiro