Abstract: The present invention provides a new method to optimize the number of required OLT GPON ports, according to the growing customer penetration rate, when deploying FTTH in low density residential and SMB areas. Additionally, it enables to minimize simultaneous customer service outages in the same zone or MDU if a distribution cell splitter fails. This method presents a new connectivity paradigm at FTTH distribution network cells based on cross-connecting the fibres between ODPs and the OSJ splitters outputs. The method spreads each splitter coverage across the cell and guarantees a fair distribution of the outputs by as many ODPs as possible, following FTTH design best practices. This approach assures that the lowest splitters will be used first and enables the optimization of GPON ports at the central office, depending on the customer penetration rate.

Abstract: A caramel is provided comprising a solid plant fat and an amount of water less than 10 wt %. The caramel exhibits a chewy texture when consumed but is yet depositable. The caramel is thus advantageously used in a confection. In addition to the caramel, the confection may comprise a crisp component. Methods of making the confection are also provided.

Abstract: This invention relates to the finding that Piperlongumine compounds, such as Piperlongumine and analogues, derivatives and prodrugs thereof, are reversible, allosteric antagonists of transient receptor potential vanilloid 2 channel (TRPV2).

Abstract: A caramel is provided comprising a solid plant fat and an amount of water less than 10 wt %. The caramel exhibits a chewy texture when consumed but is yet depositable. The caramel is thus advantageously used in a confection. In addition to the caramel, the confection may comprise a crisp component. Methods of making the confection are also provided.

Abstract: This invention relates to the finding that Piperlongumine compounds, such as Piperlongumine and analogues, derivatives and prodrugs thereof, are reversible, allosteric antagonists of transient receptor potential vanilloid 2 channel (TRPV2). Methods of treatment of conditions that are characterised by TRPV2 expression using Piperlongumine compounds and Piperlongumine compounds for use in such treatments are provided.

Abstract: A caramel is provided comprising a solid plant fat and an amount of water less than 10 wt %. The caramel exhibits a chewy texture when consumed but is yet depositable. The caramel is thus advantageously used in a confection. In addition to the caramel, the confection may comprise a crisp component. Methods of making the confection are also provided.

Abstract: This invention relates to the treatment of conditions, such as cancer, associated with 5-lipoxygenase (5-LO) expression using ?-lapachone compounds that inhibit 5-lipoxygenase (5-LO), such as ?-lapachone and derivatives thereof. Methods of treatment of conditions associated with 5-lipoxygenase (5-LO) expression as well as medical uses of ?-lapachone compounds in such methods are provided, as well as methods of selecting or prognosing cancer patients.

Abstract: This invention relates to the finding that Piperlongumine compounds, such as Piperlongumine and analogues, derivatives and prodrugs thereof, are reversible, allosteric antagonists of transient receptor potential vanilloid 2 channel (TRPV2).

Abstract: A caramel is provided comprising a solid plant fat and an amount of water less than 10 wt %. The caramel exhibits a chewy texture when consumed but is yet depositable. The caramel is thus advantageously used in a confection. In addition to the caramel, the confection may comprise a crisp component. Methods of making the confection are also provided.

Abstract: The present invention relates to processes of stabilization of cation radicals from one or more phenothiazinic compounds or derivatived compounds thereof. Another embodiment of the present invention relates to cosmeceutical formulations comprising one or more phenothiazinic compounds or derivatived compounds thereof, in combination with cosmeceutically acceptable excipients. The invention also relates to uses of one or more phenothiazinic compounds or derivatived compounds thereof, i the preparation of cosmeceutical formulations for the prevention of skin diseases and disturbances. Methods for prevention of skin diseases and disturbances are also disclosed by the present invention. Particularly, the embodiments of the present invention employ the cited one or more phenothiazinic compounds o derivatived compounds thereof in the form of their stabilized cation radicals.

Abstract: The present invention relates to a method for detecting video spammers and promoters in online video social systems. Using attributes based on the user's profile, the user's social behavior in the system, and the videos posted by the user as well as the target (responded) videos, the feasibility of applying a supervised learning method to identify polluters (spammers and promoters) is investigated.